Histopathology of hepatocellular carcinoma - when and what

When do you need to take biopsies of the liver, and what information will you get is the topic of this review on hepatocellular carcinoma (HCC). If, clinically, the differential diagnosis of HCC after imaging is suggested, a biopsy has become obligatory as a diagnostic confirmation of HCC in the non-cirrhotic liver prior to definitive therapeutic interventions, as well as in a palliative therapy concept. In the case of hepatic lesions with an uncharacteristic contrast uptake, a biopsy should be performed immediately to confirm the diagnosis of HCC. After diagnosing HCC, a treatment strategy is evaluated. Further, the biopsy, or in case of surgical treatment, the resected tissue, shows us the different subtypes of HCC, with the steatohepatitic subtype being the most common and the lymphocyte-rich subtype being the least common. Further, the histological grade of HCC is determined according to the grading system of the WHO or the Edmonson and Steiner System. Through biopsies, HCC can be differentiated from intrahepatic cholangiocarcinoma or combined hepatocellular-cholangiocarcinoma or metastases of other malignant tumors, especially metastases of the gastrointestinal tract. In summary, biopsies are fundamental in the diagnosis of HCC.

Combinatorial Game Distributions of Steiner Systems

The $P$-position sets of some combinatorial games have special combinatorial structures. For example, the $P$-position set of the hexad game, first investigated by Conway and Ryba, is the block set of the Steiner system $S(5, 6, 12)$ in the shuffle numbering, denoted by $D_{\text{sh}}$. However, few games were known to be related to Steiner systems in this way. For a given Steiner system, we construct a game whose $P$-position set is its block set. By using constructed games, we obtain the following two results. First, we characterize $D_{\text{sh}}$ among the 5040 isomorphic $S(5, 6, 12)$ with point set $\{0, 1, ..., 11\}$. For each $S(5, 6, 12)$, our construction produces a game whose $P$-position set is its block set. From $D_{\text{sh}}$, we obtain the hexad game, and this game is characterized as the unique game with the minimum number of positions among the obtained 5040 games. Second, we characterize projective Steiner triple systems by using game distributions. Here, the game distribution of a Steiner system $D$ is the frequency distribution of the numbers of positions in games obtained from Steiner systems isomorphic to $D$. We find that the game distribution of an $S(t, t + 1, v)$ can be decomposed into symmetric components and that a Steiner triple system is projective if and only if its game distribution has a unique symmetric component.

Octad Orbits for Certain Subgroups of

Using Curtis’s MOG [3], we display the orbits and orbit representatives for various subgroups of the Mathieu group acting on the octads of the Steiner system This information is deployed in [8] and [9] to study a graph associated with the largest simple Fischer group.

Laplacian Integral of Particular Steiner System

The notion of a hypergraph is motivated by a graph. In graph, every edge contains of two vertices. However, a hypergraph edges contains more than two vertices. In this article use hyperedge to mention edge of hypergraph. A finite projective plane of order n, denoted by , is a linear intersecting hypergraph. In this research finite projective plane order is Laplacian integral.

Steiner Configurations Ideals: Containment and Colouring

Given a homogeneous ideal I⊆k[x0,…,xn], the Containment problem studies the relation between symbolic and regular powers of I, that is, it asks for which pairs m,r∈N, I(m)⊆Ir holds. In the last years, several conjectures have been posed on this problem, creating an active area of current interests and ongoing investigations. In this paper, we investigated the Stable Harbourne Conjecture and the Stable Harbourne–Huneke Conjecture, and we show that they hold for the defining ideal of a Complement of a Steiner configuration of points in Pkn. We can also show that the ideal of a Complement of a Steiner Configuration of points has expected resurgence, that is, its resurgence is strictly less than its big height, and it also satisfies Chudnovsky and Demailly’s Conjectures. Moreover, given a hypergraph H, we also study the relation between its colourability and the failure of the containment problem for the cover ideal associated to H. We apply these results in the case that H is a Steiner System.

Steiner systems and configurations of points

The aim of this paper is to make a connection between design theory and algebraic geometry/commutative algebra. In particular, given any Steiner System S(t, n, v) we associate two ideals, in a suitable polynomial ring, defining a Steiner configuration of points and its Complement. We focus on the latter, studying its homological invariants, such as Hilbert Function and Betti numbers. We also study symbolic and regular powers associated to the ideal defining a Complement of a Steiner configuration of points, finding its Waldschmidt constant, regularity, bounds on its resurgence and asymptotic resurgence. We also compute the parameters of linear codes associated to any Steiner configuration of points and its Complement.

A New Approach for Examining $q$-Steiner Systems

One of the most intriguing problems in $q$-analogs of designs and codes is the existence question of an infinite family of $q$-analog of Steiner systems (spreads not included) in general, and the existence question for the $q$-analog of the Fano plane in particular.We exhibit a completely new method to attack this problem. In the process we define a new family of designs whose existence is implied by the existence of $q$-Steiner systems, but could exist even if the related $q$-Steiner systems do not exist.The method is based on a possible system obtained by puncturing all the subspaces of the $q$-Steiner system several times. We define the punctured system as a new type of design and enumerate the number of subspaces of various types that it might have. It will be evident that its existence does not imply the existence of the related $q$-Steiner system. On the other hand, this type of design demonstrates how close can we get to the related $q$-Steiner system.Necessary conditions for the existence of such designs are presented. These necessary conditions will be also necessary conditions for the existence of the related $q$-Steiner system. Trivial and nontrivial direct constructions and a nontrivial recursive construction for such designs are given. Some of the designs have a symmetric structure, which is uniform in the dimensions of the existing subspaces in the system. Most constructions are based on this uniform structure of the design or its punctured designs.

Residual $q$-Fano Planes and Related Structures

One of the most intriguing problems for $q$-analogs of designs, is the existence question of an infinite family of $q$-Steiner systems that are not spreads. In particular the most interesting case is the existence question for the $q$-analog of the Fano plane, known also as the $q$-Fano plane. These questions are in the front line of open problems in block design. There was a common belief and a conjecture that such structures do not exist. Only recently, $q$-Steiner systems were found for one set of parameters. In this paper, a definition for the $q$-analog of the residual design is presented. This new definition is different from previous known definition, but its properties reflect better the $q$-analog properties. The existence of a design with the parameters of the residual $q$-Steiner system in general and the residual $q$-Fano plane in particular are examined. We construct different residual $q$-Fano planes for all $q$, where $q$ is a prime power. The constructed structure is just one step from a construction of a $q$-Fano plane.