CONTEXT - Histopathological analysis of endometrial samples in various forms of abnormal uterine
bleeding in adjunction with clinical history of patient to identify underlying cause of bleeding. This also
helps in early diagnosis of premalignant and malignant lesions leading to their proper follow up and improved prognosis.
AIMS - Histopathological analysis of causes of abnormal uterine bleeding with their clinical correlation.
SETTINGS AND DESIGN -A prospective observational study
MATERIAL AND METHODS - This study was done in department of pathology, GSVM medical college, Kanpur. This was a
prospective study from year 2017-2018. A total of 300 cases were studied. Specimen received were xed in 10% formalin,
processed and sections of 3-4 micron were prepared, stained with H and E. Histopathological examination was done.
RESULTS - It was observed that the highest number of patients were between 41-50 years of age. (44.33%). Menorrhagia is the
most common symptom accounting for 135 (45%) patients followed by metrorrhagia accounting for 135 (45%) patients and
hypomenoorhea is the least common complaint. It was observed that there were signicantly higher number of patients with
proliferative phase – 68 (22.67%) and in endometrial hyperplasia 35 (33.66%) patients. The least common cause were
endometrial polyp, seen in 4 (1.33%) patients, gestational endometrium and gestational trophoblastic tumor accounted for 2 (
0.67%) patients. In patients who presented with metrorrhagia, secretory phase endometrium was the most common
histopathological nding accounting for 34.62% followed by proliferative phase. In cases of endometrial hyperplasia, 28 (80%)
cases were simple cystic type, 5 ( 14.29%) cases were of simple endometrial hyperplasia with atypia and complex endometrial
hyperplasia with atypia was found in 2(5.71%) cases. Among cases of endometrial hyperplasia, 28 (80%) cases were simple
cystic type, 5 ( 14.29%) cases were of simple endometrial hyperplasia with atypia and complex endometrial hyperplasia with
atypia was found in 2(5.71%) cases. Endometrial carcinoma is commonest complain in 51-60 years and >60 years age group.
CONCLUSION - Histopathological analysis of AUB causes helps in identifying the cause and early diagnosis of premalignant
and malignant cases.