Segmental analysis by speckle-tracking echocardiography of the left ventricle response to isoproterenol in male and female mice

We studied by conventional and speckle-tracking echocardiography, the response of the left ventricle (LV) to a three-week continuous infusion of isoproterenol (Iso), a non-specific beta-adrenergic receptor agonist in male and female C57Bl6/J mice. Before and after Iso (30 mg/kg/day), we characterized LV morphology and function as well as global and segmental strain. We observed that Iso reduced LV ejection in both male (−8.7%) and female (−14.7%) mice. Several diastolic function parameters were negatively regulated in males and females such as E/A, E/E′, isovolumetric relaxation time. Global longitudinal (GLS) and circumferential (GCS) strains were reduced by Iso in both sexes, GLS by 31% and GCS by about 20%. For the segmental LV analysis, we measured strain, strain rate, reverse strain rate, peak speckle displacement and peak speckle velocity in the parasternal long axis. We observed that radial strain of the LV posterior segments were more severely modulated by Iso than those of the anterior wall in males. In females, on the other hand, both posterior and anterior wall segments were negatively impacted by Iso. Longitudinal strain showed similar results to the radial strain for both sexes. Strain rate, on the other hand, was only moderately changed by Iso. Reverse strain rate measurements (an index of diastolic function) showed that posterior LV segments were negatively regulated by Iso. We then studied the animals 5 and 17 weeks after Iso treatment. Compared to control mice, LV dilation was still present in males. Ejection fraction was decreased in mice of both sex compared to control animals. Diastolic function parameters, on the other hand, were back to normal. Taken together, our study indicates that segmental strain analysis can identify LV regions that are more negatively affected by a cardiotoxic agent such as Iso. In addition, cessation of Iso was not accompanied with a complete restoration of cardiac function after four months.

Surface Evaluation of a Multi-Pass Flexible Magnetic Burnishing Brush for Rough and Soft Ground 60/40 Brass

Burnishing is an advanced finishing process that produces higher-quality surfaces with better hardness and roughness than conventional finishing processes. Herein, a flexible magnetic burnishing brush comprising stainless steel pins under permanent magnet poles was used to investigate the influence of multiple passes and directions on the produced surface of soft and rough ground prepared brass. In total, five different samples were burnished on each of the two brass samples prepared. Four samples were processed in the same direction for up to four passes and the fifth sample was processed with two passes in the opposite direction. Results indicate that there was approximately a 30% increase in hardness and an 83% increase in microroughness for rougher-surface brass samples. For smoothly prepared surfaces, there was approximately a 14% increase in hardness and a 35% increase in microroughness. In the same direction of multi-pass burnishing, increasing the number of passes negatively affected surface roughness; for rougher surfaces, the surface hardness reduced and process uniformity increased owing to surface over-hardening and flaking mechanisms, and for smoother surfaces, the hardness, roughness, and process non-uniformity increased with the number of passes owing to repeated surface deformation at some locations and high flaking at other locations. Compared to single-pass burnishing, wherein the surface roughness and microhardness showed almost no change with high process uniformity, in burnishing with two opposite-direction passes, the produced surface exhibited better surface roughness, process uniformity, and microhardness improvements owing to a reverse strain mechanism. Hence, opposite burnishing passes are recommended.

Is It So Bad or Am I So Tired?

This study contributes to an evolving dynamic perspective on the stress process as a loss cycle of resource depletion. We investigated reciprocal relationships between perceived job stressors (work overload, patient demands, and work-family conflict) and emotional exhaustion, the core strain dimension of burnout, in a 1-year cross-lagged panel study of hospital physicians (N = 95). Contrary to the causal stressor-strain hypothesis, job stressors at T1 had no significant lagged effects on emotional exhaustion at T2. However, we found a consistent pattern of reverse strain-stressor relationships, such that emotional exhaustion at T1 predicted perceived stressors at T2. Theoretical and methodological implications as well as the practical significance of our findings are discussed.

Effect of Equal Channel Angular Pressing and Repeated Rolling on Structure, Phase Transformations and Properties of TiNi Shape Memory Alloys

The nanostructured TiNi-based shape-memory alloys were synthesized by multi-step SPD deformations – ECAP plus cold rolling or drawing. It is found that the SPD processing changed the morphology of the martensite and temperature of martensite transformation. Also, we found that the mechanical and shape memory properties can be enhanced by forming nanostructures in these alloys. SPD processing renders higher strength, higher yield dislocation strength and in results - higher recovery stress and maximum reverse strain of shape memory.