Is There any Effect of lycopene’s preventing peritoneal adhesion formation in rats: An Experimental Study

Objective Purpose of the study; to demonstrate the effects of lycopene on the prevention of intraabdominal adhesions in rats with biochemical, histological and macroscopic parameters. Material methods Twenty eight rats were divided into four groups consisting of 7 rats each. Group 1 [only adhesion], Group 2 [adhesion+corn oil], Group 3 [adhesion+ 5 mg/kg lycopene], Group 4 [ adhesion+20 mg / kg lycopene]. Macroscopic adhesion score, histopathological examination, Vascular endothelial growth factor (VEGF) H-score, malondialdehyde, total anioxidant capacity and VEGF values were measured in the groups. Results There were significantly higher extend [P < 0.05], severity [P < 0.05], degree [P < 0.05] and total adhesion [P < 0.05] scores in the control group and corn-oil group than in the low lycopene group and high lycopene group. VEGF H-scores were significantly lower in lycopene-given groups, regardless of dose. When low lycopene group and high lycopene group were compared in terms of anti VEGF H-score, no significant difference was observed. Malondialdehyde levels were statistically significantly lower in the control group and high lycopene group [p<0.05]. Conclusion Biochemical parameters, histopathological examination, and adhesion scoring revealed that lycopene significantly reduced adhesion formation.

Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation

Background. Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem. Method. Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically. Results. Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p<0.001). Conclusion. 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.

Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation

Key Points Upon injury, the mesothelium recruits neutrophils to the peritoneal space, which contributes to adhesion formation. Neutrophil recruitment and macrophage-depletion kinetics in adhesions differ from the normal innate response.