Self-Adaptive Skeleton Approaches to Detect Self-Organized Coalitions From Brain Functional Networks Through Probabilistic Mixture Models

Detecting self-organized coalitions from functional networks is one of the most important ways to uncover functional mechanisms in the brain. Determining these raises well-known technical challenges in terms of scale imbalance, outliers and hard-examples. In this article, we propose a novel self-adaptive skeleton approach to detect coalitions through an approximation method based on probabilistic mixture models. The nodes in the networks are characterized in terms of robust k -order complete subgraphs ( k -clique ) as essential substructures. The k -clique enumeration algorithm quickly enumerates all k -cliques in a parallel manner for a given network. Then, the cliques, from max -clique down to min -clique, of each order k , are hierarchically embedded into a probabilistic mixture model. They are self-adapted to the corresponding structure density of coalitions in the brain functional networks through different order k . All the cliques are merged and evolved into robust skeletons to sustain each unbalanced coalition by eliminating outliers and separating overlaps. We call this the k -CLIque Merging Evolution (CLIME) algorithm. The experimental results illustrate that the proposed approaches are robust to density variation and coalition mixture and can enable the effective detection of coalitions from real brain functional networks. There exist potential cognitive functional relations between the regions of interest in the coalitions revealed by our methods, which suggests the approach can be usefully applied in neuroscientific studies.

Mining Largest Maximal Quasi-Cliques

Quasi-cliques are dense incomplete subgraphs of a graph that generalize the notion of cliques. Enumerating quasi-cliques from a graph is a robust way to detect densely connected structures with applications in bioinformatics and social network analysis. However, enumerating quasi-cliques in a graph is a challenging problem, even harder than the problem of enumerating cliques. We consider the enumeration of top- k degree-based quasi-cliques and make the following contributions: (1) we show that even the problem of detecting whether a given quasi-clique is maximal (i.e., not contained within another quasi-clique) is NP-hard. (2) We present a novel heuristic algorithm K ernel QC to enumerate the k largest quasi-cliques in a graph. Our method is based on identifying kernels of extremely dense subgraphs within a graph, followed by growing subgraphs around these kernels, to arrive at quasi-cliques with the required densities. (3) Experimental results show that our algorithm accurately enumerates quasi-cliques from a graph, is much faster than current state-of-the-art methods for quasi-clique enumeration (often more than three orders of magnitude faster), and can scale to larger graphs than current methods.

Isolation concepts applied to temporal clique enumeration

Isolation is a concept originally conceived in the context of clique enumeration in static networks, mostly used to model communities that do not have much contact to the outside world. Herein, a clique is considered isolated if it has few edges connecting it to the rest of the graph. Motivated by recent work on enumerating cliques in temporal networks, we transform the isolation concept to the temporal setting. We discover that the addition of the time dimension leads to six distinct natural isolation concepts. Our main contribution is the development of parameterized enumeration algorithms for five of these six isolation types for clique enumeration, employing the parameter “degree of isolation.” In a nutshell, this means that the more isolated these cliques are, the faster we can find them. On the empirical side, we implemented and tested these algorithms on (temporal) social network data, obtaining encouraging results.

Pivot-based Maximal Biclique Enumeration

Enumerating maximal bicliques in a bipartite graph is an important problem in data mining, with innumerable real-world applications across different domains such as web community, bioinformatics, etc. Although substantial research has been conducted on this problem, surprisingly, we find that pivot-based search space pruning, which is quite effective in clique enumeration, has not been exploited in biclique scenario. Therefore, in this paper, we explore the pivot-based pruning for biclique enumeration. We propose an algorithm for implementing the pivot-based pruning, powered by an effective index structure Containment Directed Acyclic Graph (CDAG). Meanwhile, existing literature indicates contradictory findings on the order of vertex selection in biclique enumeration. As such, we re-examine the problem and suggest an offline ordering of vertices which expedites the pivot pruning. We conduct an extensive performance study using real-world datasets from a wide range of domains. The experimental results demonstrate that our algorithm is more scalable and outperforms all the existing algorithms across all datasets and can achieve a significant speedup against the previous algorithms.