Life quality of people with HIV/AIDS needs special attention as this infectious illness are chronic and progressive that will affected in all life aspect of the patient, physically, psychologically, socially and even spiritually. Psychosocial problem that the patient had esspecially depression can affected their life qulaity by reducing it, as it life quality as we know are affected by factors such as age, gender, education, marriage status, work and how long the patient lived with the illness.the aaims of these research are to identify and explaining the relation between characteristic and depression, with life quality of people with AIDS/HIV. This research are design with crossectional study and data collection using purposive sampling with world health organisation –Quality of life instrument and cronic epidemology depression scale (CESD). The research result shows that theres a meaningfull relation betwen education, time of having illness, work and depression with life quality of patient of ODHA. Depression is the most dominant factor that affected HIV/ AIDS.
Key words : Depression, life quality, HIV/AIDS