This chapter provides an introduction to the topic of supratentorial craniotomy for mass lesion. Because there are few randomized clinical trials that guide the decision-making process for these patients, a combination of applied theory and expert consensus primarily guides anaesthetic management. With this in mind, the chapter discusses epidemiology, pre-operative considerations (including history-taking, physical examination, premedication, intravascular access and monitoring), and intra-operative management (including induction, muscle relaxation, use of cranial pins, anaesthesia maintenance, and fluid balance). It also discusses possible intra-operative complications (for example, venous air embolism, acute increase in ICP). Finally, it covers various aspects of postoperative management (including emergence, extubation, pain management, and postoperative nausea and vomiting ).