A Focused Review of Synthetic Applications of Lawesson’s Reagent in Organic Synthesis

Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exemplary results. However, the role of Lawesson’s reagent in synthesis has changed drastically, and now its use can help the chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, and the thionation of natural compounds. The ease of availability and the convenient usage of LR as a thionating agent made us compile a review on the new diverse applications on some common functional groups, such as ketones, esters, amides, alcohols, and carboxylic acids, with biological applications. Since the applications of LR are now diverse, we have also included some new classes of heterocycles such as thiazepines, phosphine sulfides, thiophenes, and organothiophosphorus compounds. Thionation of some biologically essential steroids and terpenoids has also been compiled. This review discusses the recent insights into and synthetic applications of this famous reagent from 2009 to January 2021.

Confirmation of Six Organothiophosphorus Pesticides by Chemical Derivatization at Nanogram Levels

A confirmatory procedure is described in which organothiophosphorus compounds are oxidized by neutralized sodium hypochlorite solution and the oxidation products are subjected to gas-liquid chromatography, using a flame photometric detector. Six pesticides, diazinon, ronnel, malathion, parathion, methyl parathion, and fenitrothion, were studied in 4 different substrates, peaches, blueberries, apples, and lettuce, at fortification levels of 0.25-0.5 ppm. These pesticides can be confirmed when present individually or in combination. Three pesticides, parathion, malathion, and diazinon, were shown to produce the corresponding oxons or oxygen analogs with retention times identical with the corresponding oxon reference standards.