large magnetic moment
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Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 625
Author(s):  
Ylenia Jabalera ◽  
Alberto Sola-Leyva ◽  
María P. Carrasco-Jiménez ◽  
Guillermo R. Iglesias ◽  
Concepcion Jimenez-Lopez

MamC-mediated biomimetic magnetic nanoparticles (BMNPs) have emerged as one of the most promising nanomaterials due to their magnetic features (superparamagnetic character and large magnetic moment per particle), their novel surface properties determined by MamC, their biocompatibility and their ability as magnetic hyperthermia agents. However, the current clinical application of magnetic hyperthermia is limited due to the fact that, in order to be able to reach an effective temperature at the target site, relatively high nanoparticle concentration, as well as high magnetic field strength and/or AC frequency are needed. In the present study, the potential of BMNPs to increase the temperature upon irradiation of a laser beam in the near infrared, at a wavelength at which tissues become partially transparent, is explored. Moreover, our results also demonstrate the synergy between photothermia and chemotherapy in terms of drug release and cytotoxicity, by using BMNPs functionalized with doxorubicin, and the effectiveness of this combination therapy against tumor cells in in vitro experiments. Therefore, the findings of the present study open the possibility of a novel, alternative approach to fight localized tumors.



Nano Letters ◽  
2021 ◽  
Author(s):  
Paul C. Lou ◽  
Anand Katailiha ◽  
Ravindra G. Bhardwaj ◽  
Ward P. Beyermann ◽  
Dominik M. Juraschek ◽  
...  




2018 ◽  
Vol 27 (12) ◽  
pp. 128101 ◽  
Author(s):  
Jian Zhang ◽  
Ya Deng ◽  
Ting-Ting Hao ◽  
Xiao Hu ◽  
Ya-Yun Liu ◽  
...  


2017 ◽  
Vol 1 (3) ◽  
pp. 035010
Author(s):  
R Prabhu ◽  
B N Sahu ◽  
N Venkataramani ◽  
Shiva Prasad ◽  
R Krishnan


2016 ◽  
Vol 98 ◽  
pp. 416-422 ◽  
Author(s):  
Changlong Tan ◽  
Dan Sun ◽  
Long Zhou ◽  
Xiaohua Tian ◽  
Yuewu Huang


2013 ◽  
Vol 23 (3) ◽  
pp. 4603405-4603405 ◽  
Author(s):  
Y. Nagasaki ◽  
T. Nakamura ◽  
I. Funaki ◽  
Y. Ashida ◽  
H. Yamakawa


2013 ◽  
Vol 25 (20) ◽  
pp. 206003 ◽  
Author(s):  
Tae-Young Kim ◽  
Nguyen Hoa Hong ◽  
T Sugawara ◽  
A T Raghavender ◽  
M Kurisu


2012 ◽  
Vol 100 (24) ◽  
pp. 242403 ◽  
Author(s):  
Y. R. Song ◽  
Fang Yang ◽  
Meng-Yu Yao ◽  
Fengfeng Zhu ◽  
Lin Miao ◽  
...  


2009 ◽  
Vol 42 (24) ◽  
pp. 245003 ◽  
Author(s):  
Hina Bhargava ◽  
N Lakshmi ◽  
Varkey Sebastian ◽  
V R Reddy ◽  
K Venugopalan ◽  
...  


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