Rheological analysis of sputum from patients with chronic bronchial diseases

Bronchial diseases are characterised by the weak efficiency of mucus transport through the lower airways, leading in some cases to the muco-obstruction of bronchi. It has been hypothesised that this loss of clearance results from alterations in the mucus rheology, which are reflected in sputum samples collected from patients, making sputum rheology a possible biophysical marker of these diseases and their evolution. However, previous rheological studies have focused on quasi-static viscoelastic (linear storage and loss moduli) properties only, which are not representative of the mucus mobilisation within the respiratory tract. In this paper, we extend this approach further, by analysing both quasi-static and some dynamic (flow point) properties, to assess their usability and relative performance in characterising several chronic bronchial diseases (asthma, chronic obstructive pulmonary disease, and cystic fibrosis) and distinguishing them from healthy subjects. We demonstrate that pathologies influence substantially the linear and flow properties. Linear moduli are weakly condition-specific and even though the corresponding ranges overlap, distinct levels can be identified. This directly relates to the specific mucus structure in each case. In contrast, the flow point is found to strongly increase in muco-obstructive diseases, which may reflect the complete failure of mucociliary clearance causing episodic obstructions. These results suggest that the analysis of quasi-static and dynamic regimes in sputum rheology is in fact useful as these regimes provide complementary markers of chronic bronchial diseases.

Computing a Smart Device to Classify Recurring Outbreak of Copd

Health care has experienced an unprecedented rise in the last decade. In order to keep their vital signs measured, patients will have to make regular visits to the doctor. The Cough detection device helps in the diagnosis and treatment of respiratory problems at an early age. Cough aims to remove mucus and bronchial diseases, which plays an important role in prevention and cure. More than 3 million individuals died of COPD in 2012, which is equivalent to 6 percent of all fatalities worldwide a year, according to world estimates. Citizens consider it impossible to track cough-related illnesses in rural areas because of the sophistication of the system and its testing costs. Nowadays, some people do have a mix of COPD and asthma. There is an immense demand for non-invasive ways of calculating these vital signs. This paper aims to develop and deploy a safe, inexpensive, low powered, non-intrusive, and effective device that can be worn daily and track the vital signs and show the performance to the mobile phone. The physician can also conveniently access such data through a wireless medium. This paper deals primarily with the acquisition of vital signs for signal conditioning and data: ECG, heart rate, blood pressure, body temperature, Sp02, cough rate, and respiration rate. This work proposes an innovative wearable cough detection method for early diagnosis and very early treatment of pulmonary diseases.

Impedância pulmonar como novo marcador de fisioterapia respiratória em adultos com distúrbios ventilatórios obstrutivos

Modelo do estudo: Revisão sistemática. Objetivo: Avaliar se os recursos de fisioterapia respiratória modificam a impedância pulmonar avaliada pelas técnicas de oscilações forçadas (TOF’s) em adultos com distúrbios ventilatórios obstrutivos. Método: Trata-se de uma revisão sistemática conduzida nas bases de dados PubMed, Scielo, Lilacs e PEDro, utilizando-se a seguinte estratégia de busca: Obstructive pulmonary disease OR chronic obstructive pulmonary disease OR COPD OR Bronchiectasis OR Bronchial diseases OR Cystic fibrosis OR mucoviscidosis AND impulse oscillometry OR forced oscillation techniques AND physical therapy OR physiotherapy AND Airway Resistance. Resultados: De um total de 216 artigos, apenas 3 foram incluídos. As amostras totalizaram 64 participantes, incluindo adultos com fibrose cística (FC), doença pulmonar obstrutiva crônica (DPOC) e bronquiectasias. Dois estudos utilizaram o flutter® e um realizou drenagem autógena. A impedância pulmonar foi avaliada em duas pesquisas pelo sistema de oscilometria de impulso (IOS) e em um pela TOF modificada (TOF-m). Houve redução da resistência em várias frequências, sendo que as mais frequentes foram a resistência total (3/3), a resistência central (2/3) e a periférica (2/3). Além disso, a reatância pulmonar apresentou resultados conflitantes. Conclusão: Evidenciou-se que os recursos fisioterapêuticos utilizados para remoção de secreções das vias aéreas modificam a impedância pulmonar avaliada pelas TOF’s em adultos com DVO, sendo a resistência total das vias aéreas o parâmetro com maior ganho terapêutico.

“Сhinese date”, “Lungberry” - elitist plant drug of the ancientest asiatic traditional medicines (the second report)

The lot of using Ziziphus jujube in traditional medicines phytotherapy, prescriptions species for treating patients with lung tuberculosis and other lung-bronchial diseases is observed in this article. The high effectiveness of such treating was confirmed by my own clinical experience. Fruits and leaves Zizyphus jujubа in polycomponent plant compositions protected the liver from hepatotoxic action of aggressive drugs. Some information about chemical composition Ziziphus jujube is given. This information permit only limited opportunity to base and gave prognosis of galenic forms activity. Correction carbohydrate and lipid metabolism by Zizyphus jujubа drugs may be used for treating patients with diabetes, arteries atheromatosic injuries. Immunocorrective properties this medical plant concluded in polycomponent compositions may be used for treating patients with sclerosis dissiminata. Effectiveness such compositions confirmed personally by results of phytotherapy more 500 patients with sclerosis dissiminata.