CLINICAL AND NEUROIMAGING CORRELATES OF LEIGH SYNDROME , A CASE SERIES AND REVIEW OF LITERATURE

2021 ◽  
pp. 39-40
Author(s):  
Dadireddy Leela Prasanna ◽  
Vaka Haripriyanka
Keyword(s):  
Lactic Acidosis ◽  
Sudden Death ◽  
Case Series ◽  
Leigh Syndrome ◽  
Cardiac Complications ◽  
Review Of Literature ◽  
Feeding Problems ◽  
Leigh's Disease ◽  
Acute Necrotising Encephalopathy ◽  
Acute Necrotising

Leigh syndrome, also referred to as Sub acute necrotising encephalopathy usually presents with symptoms like developmental delay, regression of neurological skills and sudden death. Approximately 25% of the patients are abnormal at birth with features like hypotonia, lactic acidosis, feeding problems, hypoglycemia, hyperbilirubinemia, cardiac complications, seizures and/or hyperammonemia. Here, we present 6 cases of Leigh's disease , who presented within 6 months of life with neurological regression and hypotonia as the predominent manifestations with MRI ndings showing Bilateral symmetrical hyperintensities in T2 weighted images which are characteristic ndings in Leigh's disease.

Reversal of DIRECT-ACTING Oral Anticoagulants in Urgent Surgery of the Proximal Aorta: case Series and Review of the literature

2019 ◽  
Vol 24 (38) ◽  
pp. 4534-4539 ◽  
Author(s):  
Eric Zimmermann ◽  
Fawzi Ameer ◽  
Berhane Worku ◽  
Dimitrios Avgerinos
Keyword(s):  
Oral Anticoagulants ◽  
Aortic Surgery ◽  
Management Strategies ◽  
Case Series ◽  
Published Data ◽  
Review Of Literature ◽  
Clotting Factors ◽  
Urgent Surgery ◽  
Direct Acting ◽  
Direct Acting Oral Anticoagulants

Introduction: Proximal aorta interventions impose significant bleeding risk. Patients on concomitant anticoagulation regimens compound the risk of bleeding in any surgery, but especially cardiothoracic interventions. The employment of direct-acting oral anticoagulants (DOAC), namely those that target clotting factors II or X, has expanded at a precipitous rate over the last decade. The emergence of their reversal agents has followed slowly, leaving clinicians with management dilemmas in urgent surgery. We discuss current reversal strategies based on the available published data and our experience with proximal aortic surgery in patients taking DOACs. Literature Search: We performed a review of literature and present three cases from our experience to offer insight into management strategies that have been historically successful. A review of literature was conducted via PubMed with the following search string: (NOAC or DOAC or TSOAC) and (aorta or aortic or (Stanford and type and a)). Case Presentation: We present three case presentations that illustrate the importance of DOAC identification and offer management strategies in mitigating associated bleeding risks in urgent or emergent surgeries. Conclusion: Treatment teams should be aware of the technical limitations of identifying and reversing DOACs. In view of the tendency toward publishing positive outcomes, more scientific rigor is required in the area of emergency DOAC reversal strategies.

Treatment of Inflammatory Macular Hole: Case Series and Review of Literature

2021 ◽  
pp. 1-7
Author(s):  
Zohreh Ebrahimi ◽  
Ali Torkashvand ◽  
Mohammad Zarei ◽  
Hooshang Faghihi ◽  
Elias Khalili Pour ◽  
...  
Keyword(s):  
Macular Hole ◽  
Case Series ◽  
Review Of Literature

scholarly journals Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature

2021 ◽  
Author(s):  
Maziar Emamikhah ◽  
Mansoureh Babadi ◽  
Mehrnoush Mehrabani ◽  
Mehdi Jalili ◽  
Maryam Pouranian ◽  
...  
Keyword(s):  
Case Series ◽  
Neurologic Complication ◽  
Review Of Literature ◽  
Opsoclonus Myoclonus Syndrome ◽  
Post Infectious

scholarly journals The Gerbode defect: a case series

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Nicholas Sunderland ◽  
Ahmed El-Medany ◽  
Justin Temporal ◽  
Laura Pannell ◽  
Gemina Doolub ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Aortic Valve ◽  
Case Series ◽  
Decompensated Heart Failure ◽  
Left Ventricular ◽  
Cardiac Complications ◽  
Low Grade ◽  
Care Needs ◽  
Intravenous Antibiotics ◽  
Gerbode Defect

Abstract Background  The Gerbode defect is a rare abnormal communication between the left ventricle (LV) and right atrium (RA). The lesion is either congenital or acquired. Acquired defects are largely iatrogenic or infective in origin. We present two cases of acquired Gerbode defects with similar clinical presentations but very different outcomes. Case summaries Patient 1 A 64-year-old male presented with features of decompensated cardiac failure and a low-grade temperature. Dehiscence of a recently implanted bioprosthetic aortic valve and high-velocity LV to RA jet (Gerbode defect) was found on echocardiography. Blood cultures grew Staphylococcus warneri and the diagnosis of infective endocarditis was established. The patient was treated with intravenous antibiotics and the aortic valve and Gerbode defect were successfully surgically repaired. Patient 2 An 81-year-old male presented after being found on the floor at home. On admission, he was clinically septic with evidence of decompensated heart failure. No clear infective focus was initially found. Transthoracic echocardiography revealed severe left ventricular impairment, with a normal bioprosthetic aortic valve. He was treated with intravenous antibiotics, but later deteriorated with evidence of embolic phenomena. Repeat echocardiography revealed a complex infective aortic root lesion with bioprosthetic valve dehiscence and flow demonstrated from the LV to RA. Unfortunately, the patient succumbed to the infection and cardiac complications. Discussion  The Gerbode defect is a rare but important complication of infective endocarditis and valve surgery. Care needs to be taken to assess for Gerbode defect shunts on echocardiogram, especially in the context of previous cardiac surgery.

Cannabis-Related Stroke: Case Series and Review of Literature

2012 ◽  
Vol 21 (7) ◽  
pp. 555-560 ◽  
Author(s):  
Niranjan N. Singh ◽  
Yi Pan ◽  
Sombat Muengtaweeponsa ◽  
Thomas J. Geller ◽  
Salvador Cruz-Flores
Keyword(s):  
Case Series ◽  
Review Of Literature ◽  
Stroke Case

scholarly journals Post-traumatic superolateral dislocation of condyle: A case series of 18 condyles with review of literature and a proposed classification.

2017 ◽  
Vol 7 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Dichen Palmo Bhutia ◽  
Divya Mehrotra ◽  
Nitin Mahajan ◽  
Debraj Howlader ◽  
Jagdish Gamit
Keyword(s):  
Case Series ◽  
Review Of Literature ◽  
Post Traumatic
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