Using the Natural Fixative from Canarium Resin of Vietnam

Aim and Objectives: Nowadays, the fixative substance from natural materials is gradually replacing the fixative substance that has been synthesized from chemicals. The purpose of the study in this research is that we created a natural fragrance from Vietnamese raw material with a fixative from Canarium Album (Lour) as a natural fixative to replace artificial fixative. Canarium plant is scientifically known as Canarium Album (Lour) Raensch of the Burseraceae family. Canarium Album L. is distributed in most of Northern provinces, central Highlands, and Southeast of Vietnam. Materials and Methods: The method of this process is resin extraction by volatile solvents. We use a knife to cut into the trunk and let the resin run out, then harvest this resin to make fixative. The resin is dissolved in alcohol 96% and the distilled alcohol is removed to obtain absolute Canarium. Evaluation method of the ability of absolute Canarium is performed by comparing it with other fixatives in fragrances. Raw canarium resins is taken directly from canarium plants then refined absolute canarium as the natural fixative. We use this fixative substance in combinations of floral, woody smells and comparison with traditional artificial fixative as Musk ketone, Musk xylene, Musk ambrette. Results: The comparison results show that the ability to keep the fragrance of scent is lower than musk ambrette, musk ketone but it is better than musk xylene. Thus, canarium resin can be used as a natural fixative to replace artificial fixative in fragrance. Conclusions: Through research and experiment, we can see Canarium resin is precious. It can be used as a good fixative in aromatherapy. This is a natural resin, a kind of resource available in Vietnam. Therefore, it is recommended for further research, exploitation, and effective use of this resource.

Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

<p>The presence of harmful substances in cosmetic products is regulated in most countries. In the European Union the Regulation (EC) No. 1223/2009 lays down the requirements for the marketing of cosmetic products. Among others, important families of compounds restricted in the Regulation are musks, allergenic fragrances and phthalates. To ensure product safety, improved analytical methods capable of reliably and reproducibly detecting the presence of traces of prohibited and/or restricted ingredients in raw materials and finished products are required. </p> <p>For the continuous improvement of the reliability of the analytical methods developed to check the compliance of cosmetic products with the Regulation, the use of appropriate surrogate standards or contaminants (substances that are added to the samples to be analyzed to establish the recovery and the reproducibility of the quantification of the analytes) are of utmost importance. One of the best kinds of surrogate standards are isotopically labeled analogs of the analytes of interest. In this work, several synthetic methods have been developed to prepare isotopically labeled analogs of atranol, chloroatranol, di-n-octylphthalate, musk xylene, and musk ambrette, which are restricted substances in cosmetic articles.</p>

Synthesis of Deuterated Surrogate Standards for the Analysis of Legally Regulated Substances in Cosmetics

<p>The presence of harmful substances in cosmetic products is regulated in most countries. In the European Union the Regulation (EC) No. 1223/2009 lays down the requirements for the marketing of cosmetic products. Among others, important families of compounds restricted in the Regulation are musks, allergenic fragrances and phthalates. To ensure product safety, improved analytical methods capable of reliably and reproducibly detecting the presence of traces of prohibited and/or restricted ingredients in raw materials and finished products are required. </p> <p>For the continuous improvement of the reliability of the analytical methods developed to check the compliance of cosmetic products with the Regulation, the use of appropriate surrogate standards or contaminants (substances that are added to the samples to be analyzed to establish the recovery and the reproducibility of the quantification of the analytes) are of utmost importance. One of the best kinds of surrogate standards are isotopically labeled analogs of the analytes of interest. In this work, several synthetic methods have been developed to prepare isotopically labeled analogs of atranol, chloroatranol, di-n-octylphthalate, musk xylene, and musk ambrette, which are restricted substances in cosmetic articles.</p>

Determination of Musk Ambrette in Fragrance Products by Capillary Gas Chromatography with Electron Capture Detection: Interlaboratory Study

A gas chromatographic method that uses an internal standard additions technique is described for the determination of musk ambrette (MA) in fragrance products. A solution containing the product and a known amount of an internal standard, musk tibetene (MT), is injected directly into a gas chromatograph equipped with an electron capture detector. The chromatographic separation of the components on a wide-bore fused silica capillary column is recorded and a response constant is calculated from MA and MT peak heights. A similar response constant is also calculated for a standard solution containing known concentrations of MA and MT. The MA content of the fragrance product is then calculated. Average recoveries of MA from fragrance products ranged from 97.6 to 102.3%. The method was also evaluated collaboratively by 6 laboratories. In this study, the reproducibility relative standard deviation for MA in 6 fragrance test samples ranged from 2.78 to 22.87%.