cerenkov light
Recently Published Documents


TOTAL DOCUMENTS

121
(FIVE YEARS 15)

H-INDEX

15
(FIVE YEARS 2)

2021 ◽  
Vol 16 (01) ◽  
pp. P01007-P01007
Author(s):  
S. Yamamoto ◽  
Y. Nagao ◽  
K. Kurita ◽  
M. Yamaguchi ◽  
N. Kawachi

2020 ◽  
Author(s):  
Seiichi Yamamoto ◽  
Takuya Yabe ◽  
Takashi Akagi ◽  
Yoshiyuki Hirano

Radiation ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 5-17
Author(s):  
Joël Daouk ◽  
Batoul Dhaini ◽  
Jérôme Petit ◽  
Céline Frochot ◽  
Muriel Barberi-Heyob ◽  
...  

Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of this strategy is the weak light penetration in the tissues. To overcome this issue, recent studies proposed to generate visible light in situ with radioactive isotopes emitting charged particles able to produce Cerenkov radiation. In vitro and preclinical results are appealing, but the existence of a true, lethal phototherapeutic effect is still controversial. In this article, we have reviewed previous original works dealing with Cerenkov-induced PDT (CR-PDT). Moreover, we propose a simple analytical equation resolution to demonstrate that Cerenkov light can potentially generate a photo-therapeutic effect, although most of the Cerenkov photons are emitted in the UV-B and UV-C domains. We suggest that CR-PDT and direct UV-tissue interaction act synergistically to yield the therapeutic effect observed in the literature. Moreover, adding a nanoscintillator in the photosensitizer vicinity would increase the PDT efficacy, as it will convert Cerenkov UV photons to light absorbed by the photosensitizer.


Sign in / Sign up

Export Citation Format

Share Document