ion irradiation
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2022 ◽  
Vol 277 ◽  
pp. 115566
Author(s):  
Tran Van Phuc ◽  
Miroslaw Kulik ◽  
Le Hong Khiem ◽  
Afag Madadzada ◽  
Marcin Turek ◽  
...  
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2022 ◽  
Vol 892 ◽  
pp. 162043
Author(s):  
Shengyuan Peng ◽  
Ke Jin ◽  
Xin Yi ◽  
Zhaohui Dong ◽  
Xun Guo ◽  
...  

Author(s):  
Shin-ichi Sawada

Abstract Track-etched nanoporous membranes prepared by swift heavy ion irradiation are promising for separation processes such as water purification. However, one drawback is that multiple pores are undesirably formed by pore overlapping to reduce separation performance. The techniques for predicting the size and amount of multiple pores in detail are still underdeveloped, which hinders the precise membrane design. In this study, a computer simulation program was developed to predict the size distribution of the track-etched pores. The program generates a number of single pores on the virtual grid plane to simulate random ion bombardment, finds multiple pores containing several single pores, and determines the multiple pore size by counting the inside grid points. All the multiple pores are categorized into different size classes, and the areal percentage occupied by the pores belonging to each size class is estimated. The simulation algorithm and the results of a model case simulation were described.


Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 196
Author(s):  
Xin Wu ◽  
Ruxue Yang ◽  
Xiyue Chen ◽  
Wei Liu

Nanopore structure presents great application potential especially in the area of biosensing. The two-dimensional (2D) vdW heterostructure nanopore shows unique features, while research around its fabrication is very limited. This paper proposes for the first time the use of ion beam irradiation for creating nanopore structure in 2D vdW graphene-MoS2 heterostructures. The formation process of the heterostructure nanopore is discussed first. Then, the influence of ion irradiation parameters (ion energy and ion dose) is illustrated, based on which the optimal irradiation parameters are derived. In particular, the effect of stacking order of the heterostructure 2D layers on the induced phenomena and optimal parameters are taken into consideration. Finally, uniaxial tensile tests are conducted by taking the effect of irradiation parameters, nanopore size and stacking order into account to demonstrate the mechanical performance of the heterostructure for use under a loading condition. The results would be meaningful for expanding the applications of heterostructure nanopore structure, and can arouse more research interest in this area.


2022 ◽  
Vol 11 ◽  
Author(s):  
Dandan Wang ◽  
Ruifeng Liu ◽  
Qiuning Zhang ◽  
Hongtao Luo ◽  
Junru Chen ◽  
...  

PurposeGiven the higher precision accompanied by optimized sparing of normal tissue, charged particle therapy was thought of as a promising treatment for pancreatic cancer. However, systematic preclinical studies were scarce. We aimed to investigate the radiobiological effects of charged particle irradiation on pancreatic cancer cell lines.MethodsA systematic literature search was performed in EMBASE (OVID), Medline (OVID), and Web of Science databases. Included studies were in vitro English publications that reported the radiobiological effects of charged particle irradiation on pancreatic cancer cells.ResultsThirteen carbon ion irradiation and seven proton irradiation in vitro studies were included finally. Relative biological effectiveness (RBE) values of carbon ion irradiation and proton irradiation in different human pancreatic cancer cell lines ranged from 1.29 to 4.5, and 0.6 to 2.1, respectively. The mean of the surviving fraction of 2 Gy (SF2) of carbon ion, proton, and photon irradiation was 0.18 ± 0.11, 0.48 ± 0.11, and 0.57 ± 0.13, respectively. Carbon ion irradiation induced more G2/M arrest and a longer-lasting expression of γH2AX than photon irradiation. Combination therapies enhanced the therapeutic effects of pancreatic cell lines with a mean standard enhancement ratio (SER) of 1.66 ± 0.63 for carbon ion irradiation, 1.55 ± 0.27 for proton irradiation, and 1.52 ± 0.30 for photon irradiation. Carbon ion irradiation was more effective in suppressing the migration and invasion than photon irradiation, except for the PANC-1 cells.ConclusionsCurrent in vitro evidence demonstrates that, compared with photon irradiation, carbon ion irradiation offers superior radiobiological effects in the treatment of pancreatic cancer. Mechanistically, high-LET irradiation may induce complex DNA damage and ultimately promote genomic instability and cell death. Both carbon ion irradiation and proton irradiation confer similar sensitization effects in comparison with photon irradiation when combined with chemotherapy or targeted therapy.


Author(s):  
Elayaraja Kolanthai ◽  
M.I. Ahymah Joshy ◽  
K. Thanigai Arul ◽  
P. Manojkumar ◽  
N. Rameshbabu ◽  
...  

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