EP1160 Prognostic factor in primary vulvar squamous-cell cancer in the context of FIGO 1988 and 2009 and Brigham and women's vulvar tumor classification system

ABSTRACT Introduction Controversy exists about the prognosis of squamous cell carcinoma of the tongue between young and older patients. Our objective was to evaluate age as a prognostic factor in oral tongue cancer. Materials and methods A retrospective study was conducted by reviewing charts of 61 patients. They were divided into two age groups, below 40 years and above 40 years. Data regarding epidemiology pathology report, tumor differentiation, staging, treatment and outcome were obtained. The length of survival and disease recurrence was calculated and compared in this two age group. Statistical analysis was performed using student, t-test. Results The result showed no significant difference in prognosis, tumor differentiation or staging related to age in oral tongue cancer. Conclusion Although age is not a significant prognostic factor in oral tongue cancer, the disease etiology is likely different, we recommend prompt and aggressive treatment of young patients. How to cite this article Al-Qahtani K, Brousseau V, Islam T. prognosis of patients less than 40 Years of Age with Squamous Cell Cancer of the Oral Tongue. Int J Head Neck Surg 2015;6(2): 53-56.

Download Full-text

Prognostic significance of stromal eosinophilic infiltration in cancer of the larynx

Otolaryngology ◽

10.1016/j.otohns.2005.01.041 ◽

2005 ◽

Vol 132 (6) ◽

pp. 869-873 ◽

Cited By ~ 15

Author(s):

ÇBrahim Ercan ◽

Burak Çakir ◽

Tülay Baçak ◽

Tuncay Özdemir ◽

Árahim Sayin ◽

...

Keyword(s):

Prognostic Factor ◽

Squamous Cell ◽

Vascular Invasion ◽

Squamous Cell Cancer ◽

Cell Cancer ◽

Low Grade ◽

Depth Of Invasion ◽

Tumor Differentiation ◽

Laryngeal Squamous Cell Cancer

OBJECTIVE: To investigate prevalence and possible role of tumor-associated tissue eosinophilia (TATE) as a prognostic factor in laryngeal squamous cell cancer. STUDY DESIGN: Prospective case series. METHODS: Seventy-eight consecutive patients with diagnosis of squamous cell carcinoma of the larynx and who were treated surgically in our center were evaluated. The possible role of TATE as a prognostic factor in laryngeal squamous cell cancer was investigated with respect to tumor differentiation, depth of invasion, perineural and vascular invasion (histopathological parameters), and neck metastasis (clinical parameter). The relation between presence of TATE and age was also examined. RESULTS: TATE was positive in the tumors of 32% of the patients, including low grade, 20 (26%); medium grade, 4 (5%); and high grade, 1 (1%). The relationships between TATE and tumor differentiation, perineural invasion, vascular invasion, pathologic N stage, and depth of invasion were not statistically significant ( P >0.05). According to Spearman correlation analysis ( r = −0.383, P = 0.001), there is a negative correlation between TATE and age. Ages of TATE-positive patients tend to be clustered in the 5th and 6th decades of life, whereas the TATE-negative patients’ ages tend to be clustered in the 6th and 7th decades. CONCLUSIONS: TATE has no correlation with prognostic parameters in laryngeal squamous cell cancer. Presence of TATE is highly correlated with age. Incidence of TATE is very low over the age of 60 years, and this may suggest that age influences the tissue inflammatory response to tumor. Further investigation is needed to explain the associations of TATE and age and also the host response to malignancy.

Download Full-text