Polyprenols as Promising Neuropharmacological Agents

The article presents information about the potential effectiveness of polyprenols as a means of neuropharmacology. To confirm the neuroprotective effect of polyprenols, their effectiveness was studied in the case of chronic exposure to carbendazim. In such conditions, chronic damage to nerve cells is developed through violating the homeostasis of neurospecific proteins (S-100, MBP) and trophic factors, as well as a sharp activation of lipid peroxidation processes. The administration of polyphenols (2 mg/kg once a day for 2 weeks) to laboratory animals under modelled conditions reduced the manifestations of neurointoxication and statistically significantly contributed to the reduction of oxidative stress and activation of antioxidant defence enzymes (glutathione-S-transferase).

Antioxidant enzymes in the liver of Chelidonichthys obscurus from the Montenegrin coastline

The activities of antioxidant defence enzymes — total, manganese and copper zinc containing superoxide dismutase (Tot SOD, Mn SOD, CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) — in the liver of longfin gurnard (Chelidonichthys obscurus) from the Montenegrin coastline (Adriatic sea) were investigated. The specimens were collected in winter (February) and late spring (May) at two localities: Platamuni (PL, potentially unpolluted) and the Estuary of the River Bojana (EB, potentially polluted). The obtained results show that the activities of Mn SOD, CAT, GSH-Px and GST in winter were significantly lower at EB than at PL. In spring, the activities of CAT and GST were decreased, while GR activity was increased at EB in comparison to PL. The activities of Mn SOD and GST at PL were decreased and GSH-Px, GR and GST activities at EB were increased in spring compared to winter. Our work represents the first study of liver antioxidant enzymes of longfin gurnard from the Montenegrin coastline and reveals that locality, as a variable, has a greater influence on antioxidant enzymes and biotransformation phase II enzyme GST activities compared to season.

The activity of the first line enzymes of the antioxidant defence in the liver of pubertal rats during stress

The purpose of the work was to study the activity of the first line antioxidant defence enzymes in postmitochondrial fraction of liver of pubertal rats during immobilization stress. During short-term immobilization the activity of catalase and glutathione peroxidase (GPx) decreased. Long-term immobilization was accompanied by activation of GPx and superoxide dismutase in the liver postmitochondrial fraction of late pubertal and adult animals, but not early pubertal rats.