protein pharmaceuticals
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scholarly journals Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

2021 ◽  
pp. 1-32
Author(s):  
Joana T. Pinto ◽  
Eva Faulhammer ◽  
Johanna Dieplinger ◽  
Michael Dekner ◽  
Christian Makert ◽  
...  
Keyword(s):  
Spray Drying ◽  
Literature Analysis ◽  
Protein Pharmaceuticals

scholarly journals Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4357 ◽  
Author(s):  
Schöneich
Keyword(s):  
Hydrogen Atom Transfer ◽  
Chemical Degradation ◽  
Addition Reactions ◽  
Thiyl Radicals ◽  
Pharmaceutical Protein ◽  
Pharmaceutical Proteins ◽  
Cross Links ◽  
Human And Mouse ◽  
Protein Pharmaceuticals

Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.

scholarly journals Immunogenicity of Protein Pharmaceuticals

2019 ◽  
Vol 108 (5) ◽  
pp. 1637-1654 ◽  
Author(s):  
Robert Dingman ◽  
Sathy V. Balu-Iyer
Keyword(s):  
Protein Pharmaceuticals

Role of Glycosylation in Modulating Therapeutic Efficiency of Protein Pharmaceuticals

2019 ◽  
pp. 131-143
Author(s):  
Parvaiz Ahmad Dar ◽  
Usma Manzoor ◽  
Snowber Shabir Wani ◽  
Fasil Ali ◽  
Tanveer Ali Dar
Keyword(s):  
Therapeutic Efficiency ◽  
Protein Pharmaceuticals

scholarly journals Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues

2018 ◽  
Vol 107 (8) ◽  
pp. 2013-2019 ◽  
Author(s):  
M. Reza Nejadnik ◽  
Theodore W. Randolph ◽  
David B. Volkin ◽  
Christian Schöneich ◽  
John F. Carpenter ◽  
...  
Keyword(s):  
Protein Pharmaceuticals
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