Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)

A 44-year-old Caucasian man presented with seizures and cognitive impairment. He had marked retinal drusen, and MR brain scan showed features of cerebral small vessel disease; he was diagnosed with a leukoencephalopathy of uncertain cause. He died at the age of 46 years and postmortem brain examination showed widespread small vessel changes described as a vasculopathy of unknown cause. Seven years postmortem, whole-genome sequencing identified a homozygous nonsense HTRA1 mutation (p.Arg302Ter), giving a retrospective diagnosis of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy.

The Image Information Of Mri Brain In Axial Diffusion Weighted Image (Dwi) With Variation B Value In Ischemic Stroke

The purpose of the research is to identify the differences between image information of MRI Brain in axial plane Diffusion Weighted Image (DWI) sequence and variation b value in case ischemic stroke, and to determine optimal b value in examination MRI Brain in case Ischemic Stroke. This research was a quantitative research with experimental approach. This research was done in Panti Rapih Hospital, Yogyakarta and used 8 ischemic stroke patients with 3 variasion b value (500s/mm2, 1000 s/mm2, 1500 s/mm2) and 3 radiologists as respondents. The data were analyzed using Friedman test. Result showed that there was difference between image information of MRI Brain in axial plane Diffusion Weighted Image (DWI) sequence and variation b value in case ischemic stroke with p0.05 which means there is a difference between Basal Ganglia, Cerebellum, and the border of the infarction. Meanwhile, Cortex Cerebri, Thalamus and Pons obtained no difference in image information and the optimal b value for MRI Brain examination of ischemic stroke 1500 s/mm2. Based on the result there was a difference between image information of MRI Brain in axial plane Diffusion Weighted Image (DWI) sequence and variation b value in case ischemic stroke. Optimal value of variation b value for MRI Brain examination of ischemic stroke was 1500 s/mm2.

The Pituitary Gland Measurements in Sudanese Females using Magnetic Resonance Imaging

Background: Assessment of the pituitary gland (PG) measurements is essential for the diagnosis of many pathological conditions. For Sudanese adult females, however, there have been no studies and no reference values for PG measurements. Therefore, the aim of this study was to determine the regular dimensions of the PG, using MRI, and to correlate these measurements with age, the shape of sella turcica, puberty age, and parity in Sudanese females. Methods and Results: This cross-sectional study was done to assess the PG measurement in Sudanese adult females (n=63) aged between 20 years and 60 years who underwent a brain MRI examination between 2015 and 2019. The study was conducted at Yastabshiroon Umodorman Medical Center (Khartoum, Sudan). The MRI brain examination found that the mean length, depth, width, and volume of the PG were 10.57±1.27 mm, 5.56±1.42 mm, 12.18±1.67 mm, and 356.38±100.22 mm3, respectively. Concerning the shape of the sella turcica, the study revealed that the convex and concave shape were more frequent than others (39.7% and 34.9%, respectively). The depth, width, length, and volume of the gland had changed significantly with pituitary shapes. The PG depth was significantly higher in nulliparous females than multiparous ones. Conclusion: The PG measurement in adult Sudanese females decreased in the sagittal depth and volume gradually till the age of 50 years then returned to increasing after age 50. Younger females in the age group of 20-30 years had a larger depth and volume of the gland than other age groups.

ESTIMATION OF ENTRANCE SURFACE RADIATION DOSE TO THYROID REGION IN COMPUTED TOMOGRAPHY BRAIN EXAMINATION

Objective: The objective of this study was to estimate the entrance surface radiation dose to the thyroid region in a computed tomography (CT) brain scan.Methods: Unfors Multi-O-Meter equipment was used to measure the entrance surface at the thyroid region of adult patients ranging from 18 to 70 years of age. A total of 115 patients were included in the study based on convenience sampling. The Multi-O-Meter was kept at the thyroid region during the scan, and the values for entrance surface dose (ESD) were noted from its monitor after the scan was complete.Results: The obtained data were analyzed and violate normal distribution; therefore, the median and quartiles were computed. The overall median (Q1, Q2), ESD of the patients, was 1.335 (1.213, 1.529) mGy. The minimum and maximum dose values recorded were 1.015 mGy and 1.964 mGy, respectively.Conclusions: The result showed a significant amount of entrance surface radiation dose to the thyroid region while taking a brain scan. This data can be used for optimization of radiation protection while undergoing CT scans of brain to reduce exposure to thyroid region.

ESTIMATION OF ENTRANCE SURFACE RADIATION DOSE TO THYROID REGION IN COMPUTED TOMOGRAPHY BRAIN EXAMINATION

Objective: The objective of this study was to estimate the entrance surface radiation dose to the thyroid region in a computed tomography (CT) brain scan.Methods: Unfors Multi-O-Meter equipment was used to measure the entrance surface at the thyroid region of adult patients ranging from 18 to 70 years of age. A total of 115 patients were included in the study based on convenience sampling. The Multi-O-Meter was kept at the thyroid region during the scan, and the values for entrance surface dose (ESD) were noted from its monitor after the scan was complete.Results: The obtained data were analyzed and violate normal distribution; therefore, the median and quartiles were computed. The overall median (Q1, Q2), ESD of the patients, was 1.335 (1.213, 1.529) mGy. The minimum and maximum dose values recorded were 1.015 mGy and 1.964 mGy, respectively.Conclusions: The result showed a significant amount of entrance surface radiation dose to the thyroid region while taking a brain scan. This data can be used for optimization of radiation protection while undergoing CT scans of brain to reduce exposure to thyroid region.