A model-based approach to designing developmental toxicology experiments using sea urchin embryos

The key aim of this paper is to suggest a more quantitative approach to designing a dose–response experiment, and more specifically, a concentration–response experiment. The work proposes a departure from the traditional experimental design to determine a dose–response relationship in a developmental toxicology study. It is proposed that a model-based approach to determine a dose–response relationship can provide the most accurate statistical inference for the underlying parameters of interest, which may be estimating one or more model parameters or pre-specified functions of the model parameters, such as lethal dose, at maximal efficiency. When the design criterion or criteria can be determined at the onset, there are demonstrated efficiency gains using a more carefully selected model-based optimal design as opposed to an ad-hoc empirical design. As an illustration, a model-based approach was theoretically used to construct efficient designs for inference in a developmental toxicity study of sea urchin embryos exposed to trimethoprim. This study compares and contrasts the results obtained using model-based optimal designs versus an ad-hoc empirical design.

Mechanistic-Empirical Faulting Prediction Model for Unbonded Concrete Overlays of Concrete

Transverse joint faulting is a distress that develops in unbonded concrete overlays (UBOL). Historically, faulting models used for predicting the performance of a UBOL have not accounted for the effects of the interlayer between the overlay and the existing pavement on the development of faulting. This is a significant limitation since characteristics of the interlayer play a primary role in the rate at which faulting develops in UBOLs. To develop a more robust faulting prediction model for UBOLs, enhancements were made to the current process to address this limitation. This includes the use of a structural response model that can account for the effects of the interlayer properties on the response of the UBOL. Additional enhancements include the use of a deflection basin of the overlay (in lieu of corner deflections of an equivalent slab system for accumulating differential energy [DE]), the incorporation of an erosion model that can account for the erodibility of the interlayer material, the adjustment of the incremental faulting equations to accommodate small slab sizes that are common in UBOLs, and a national calibration using faulting data from in-service UBOLs. This enhanced faulting model has been implemented in the mechanistic-empirical design tool Pitt UBOL-ME.

Development of a Design Catalog for Bonded Concrete Overlay Pavements Considering the Regional Characteristics of Korea

The design of overlay pavement in Korea, using the American empirical method, does not consider the unique Korean climate, pavement material, and traffic conditions. Therefore, in this study, a mechanistic–empirical design catalog for bonded concrete overlays (BCO) that are appropriate for Korean pavement conditions was developed. First, the thickness of the new pavement slab was determined through the Korean pavement design method, which uses a mechanistic–empirical design program according to the traffic volume of the region with the worst climatic conditions in Korea. Then, finite element analysis models of new jointed concrete and BCO pavements were developed to determine the BCO thickness by adjusting it until the stress–strength ratio of an existing slab of BCO pavement was equal to that of a new concrete pavement slab. By repeating this procedure, a design catalog was developed for the sustainable management of concrete pavement according to the traffic volume, elastic modulus, and thickness of the existing slab after milling. The appropriateness of the BCO thickness predicted by the design catalog was verified by comparing it with that predicted by other design methods.

Quantification of vertical, lateral, and longitudinal fastener demand in broken spike track: Inputs to mechanistic-empirical design

To address a recent challenge related to broken spikes in premium elastic fastening systems that have led to at least ten derailments and require manual walking inspections as well as build upon mechanistic-empirical (M-E) design principles for future fastening system component design, this paper quantifies the vertical, lateral, and longitudinal fastening system loads under revenue service traffic in a curve that has regularly experienced spike fastener fatigue failures. Previous data has indicated that the high rail of Track 3 experienced the most failures at this location. The data from this investigation sheds light into why failures are more predominant at this location than others and how the vertical, lateral, and longitudinal loads cannot be considered independently. Specifically, while the magnitude of the applied loading was the lowest on the high rail of Track 3, the threshold for failure was also the lowest given the operations at this location led to unloading of the high rail, thus indirectly highlighting the importance of friction within a fastening system. The data also show the high rail of Track 3 was subjected to the highest L/V load ratios and was an outlier in the typical lateral load reversals applied likely leading to spike stress reversals and thus a shorter fatigue life. Finally, based upon the data, it is recommended that to mitigate spike failures, as well as similar fastener challenges in other track types (e.g. rail seat deterioration, etc.) railroads should ensure trains operate close to the balance speed and use fastening system that transfer loads through friction. This study also provides novel data for M-E design of fastening systems.