Ball milling – a new concept for predicting degradation profiles in active pharmaceutical ingredients

Forced oxidative mechanochemical degradation of clopidogrel hydrogensulfate as a model compound leads to selective formation of degradants in less than 15 minutes.

Polymer degradation: a short review

The reader will find basic knowledge about the degradation of polymers, its causes, course and consequences in a broader context, as indicated through the list of the chapter titles: Introduction; Depolymerization; Initiated cleavage (degradation) of macromolecules; Thermal degradation; Photochemical degradation; Mechanochemical degradation; Oxidative degradation; Polymer burning; Kinetics of cleaving macromolecules when chain depolymerization is negligible; Degradation in polymer recycling; Protection of polymers against degradation.

Disposal of the Lithium-ion Current Sources by Mechanochemical Degradation

Lithium-ion current sources in a ball mill and comparing this energy with the binding energies of lithium ions with various metals of a cathode material for mechanochemical destruction. The binding energies of lithium ions in various lithium-containing compounds are shown. The calculation of the technological and design parameters of the ball mill to determine the magnitude of the energy of the collision of the grinding bodies and the grinded material. The graphic dependences are given, allowing to reveal the influence of the ratio of the diameter of the balls and their number on the process of mechanochemical destruction.