protein kinase n
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scholarly journals Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin

Circulation ◽  
2019 ◽  
Vol 140 (21) ◽  
pp. 1737-1752 ◽  
Author(s):  
Teruhiro Sakaguchi ◽  
Mikito Takefuji ◽  
Nina Wettschureck ◽  
Tomonari Hamaguchi ◽  
Mutsuki Amano ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Cardiac Dysfunction ◽  
Protein Kinase N ◽  
Related Transcription Factor

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

2019 ◽  
Vol 21 (9) ◽  
pp. 1093-1101 ◽  
Author(s):  
Alexander Wallroth ◽  
Philipp A. Koch ◽  
Andrea L. Marat ◽  
Eberhard Krause ◽  
Volker Haucke
Keyword(s):  
Protein Kinase ◽  
Protein Kinase N

scholarly journals Centrosome- and Golgi-Localized Protein Kinase N-Associated Protein Serves As a Docking Platform for Protein Kinase A Signaling and Microtubule Nucleation in Migrating T-Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Seow Theng Ong ◽  
Madhavi Latha Somaraju Chalasani ◽  
M. H. U. Turabe Fazil ◽  
Praseetha Prasannan ◽  
Atish Kizhakeyil ◽  
...  
Keyword(s):  
T Cells ◽  
Protein Kinase ◽  
Protein Kinase A ◽  
Microtubule Nucleation ◽  
Protein Kinase N ◽  
Kinase A

scholarly journals Cell Polarity Regulates Biased Myosin Activity and Dynamics during Asymmetric Cell Division via Drosophila Rho Kinase and Protein Kinase N

2017 ◽  
Vol 42 (2) ◽  
pp. 143-155.e5 ◽  
Author(s):  
Anna Tsankova ◽  
Tri Thanh Pham ◽  
David Salvador Garcia ◽  
Fabian Otte ◽  
Clemens Cabernard
Keyword(s):  
Cell Division ◽  
Protein Kinase ◽  
Cell Polarity ◽  
Asymmetric Cell Division ◽  
Rho Kinase ◽  
Protein Kinase N

scholarly journals Drosophila protein kinase N (Pkn) is a negative regulator of actin–myosin activity during oogenesis

2014 ◽  
Vol 394 (2) ◽  
pp. 277-291 ◽  
Author(s):  
Tânia Ferreira ◽  
Pedro Prudêncio ◽  
Rui Gonçalo Martinho
Keyword(s):  
Protein Kinase ◽  
Negative Regulator ◽  
Protein Kinase N ◽  
Drosophila Protein

scholarly journals Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

2014 ◽  
Vol 34 (2) ◽  
Author(s):  
Matthew D. Falk ◽  
Wei Liu ◽  
Ben Bolaños ◽  
Keziban Unsal-Kacmaz ◽  
Anke Klippel ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinetic Analysis ◽  
Enzyme Kinetics ◽  
Small Molecule ◽  
Targeted Therapies ◽  
Small Molecule Inhibitors ◽  
Kinetic Mechanism ◽  
Protein Kinase N ◽  
Isoform Selectivity

We conducted kinetic analysis of the relatively unexplored PKN family and effects of lipids, and identified potent inhibitors with various isoform selectivity. The kinetic mechanism, lipid activators and inhibitors could be useful for understanding PKN biology and developing PKN-targeted therapies.

scholarly journals Fragmentation of Protein Kinase N (PKN) in the Hydrocephalic Rat Brain

2007 ◽  
Vol 40 (4) ◽  
pp. 113-121 ◽  
Author(s):  
Norifumi Okii ◽  
Taku Amano ◽  
Takahiro Seki ◽  
Hiroaki Matsubayashi ◽  
Hideyuki Mukai ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Rat Brain ◽  
Protein Kinase N
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