Valorization of Vegetal Fibers in Anti-Fissuration Screed Mortar Formulation

This work, which is part of the FIBRABETON project, aims to anti-fissuration screed formulations proposition based on natural fibers and comparing these formulations to a synthetic fiber-screed formulation. Different natural fiber (hemp, flax, miscanthus and bamboo) with contents rangingfrom 0.4% to 0.8% were tested. The spread (slump), the shrinkage and mechanical strength (flexural and compressive) studies were carried out. SEM images of natural fibers and natural fibers screed formulation were analyzed. Overall, it is found that all natural fibers screed formulations tested, have shown better behaviour than the synthetic fibers screed formulation in point of view workability, shrinkage and mechanical properties. The lowest shrinkage value is found in the case of the H5 (5 mm long hemp fibers) screed formulation. Generally speaking, the mechanical strength values (flexural and compressive) are more or less similar between natural soft fibers (hemp and flax) and rigid fibers (miscanthus and bamboo). Taking in account slump, shrinkage and mechanical behavior, the proposed good compromise in this work is the H5 screed formulation.

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions

Sickle cell disease (SCD) results from a hemoglobin (Hb) mutation βGlu6 → βVal6 that changes normal Hb (HbA) into sickle Hb (HbS). Under hypoxia, HbS polymerizes into rigid fibers, causing red blood cells (RBCs) to sickle; leading to numerous adverse pathological effects. The RBC sickling is made worse by the low oxygen (O2) affinity of HbS, due to elevated intra-RBC concentrations of the natural Hb effector, 2,3-diphosphoglycerate. This has prompted the development of Hb modifiers, such as aromatic aldehydes, with the intent of increasing Hb affinity for O2 with subsequent prevention of RBC sickling. One such molecule, Voxelotor was recently approved by U.S. FDA to treat SCD. Here we report results of a novel aromatic aldehyde, VZHE-039, that mimics both the O2-dependent and O2-independent antisickling properties of fetal hemoglobin. The latter mechanism of action—as elucidated through crystallographic and biological studies—is likely due to disruption of key intermolecular contacts necessary for stable HbS polymer formation. This dual antisickling mechanism, in addition to VZHE-039 metabolic stability, has translated into significantly enhanced and sustained pharmacologic activities. Finally, VZHE-039 showed no significant inhibition of several CYPs, demonstrated efficient RBC partitioning and high membrane permeability, and is not an efflux transporter (P-gp) substrate.

Modeling Strength and Stress Diffusion in Hip Prostheses with Nano-Reinforced Composites

nanoscale rigid particles or plates are investigated for their reinforcing properties used as a binding material for holding together many long fiber composites. Very strong and light laminates can be made by layering thin sheets of rigid fibers (e.g. carbon fibers, glass fibers) with epoxy resin, for example, as a filler for spaces between fibers. Saint-Venant’s principle is concerned with assessing the effect of anisotropy on the decay of stresses with distance from the boundary of an elastic solid subjected to self-equilibrated end loads. The distance required for this transition is longer for rigid composites than for isotropic materials. The extra distance will allow bio-stress to be diffused to the boundary where end effects occur. This study is based on a biomimetic idea come from the mechanical behavior of biological materials as governed by underlying nanostructure, with the potential for synthesis into engineered materials. Mixing extremely small, rigid, randomly oriented nanoplates or nanotubes into the binding phase between the fibers is found to make the composite more isotropic near the ends and therefore mitigate damage.