Self-assembled Nanomaterials Type Layered Double Hydroxides Antibiotics Used as Drug Delivery Vectors

Due to their biocompatibility, nanomaterials type layered double hydroxides (LDHs) development has attracted many researchers attention especially in medical area using them as drug delivery vectors. Their efficiency is due to the drug controlled release from the interlayer space of LDHs matrices. The controlled drug delivery characteristic is due to the reduction of drug concentration variations and maintains the desired level of drug concentration for long time. Furthermore, this action limits adverse effects and reduces the therapy duration, enhancing bactericidal activity and leading to an effective treatment. This work highlights the synthesis and characterization of hybrid structures type LDHs- tobramycin having application as antibacterial factor against Pseudomonas aeruginosa. The obtained self-assembled structures were morphologically characterized in order to point out the drug-interlayered products. Results indicate superior properties of MgAlLDHs and ZnAlLDHs behaving as host for a wide variety of molecules generally and, in our case, for tobramycin as guest.