The vaccination threshold for SARS-CoV-2 depends on the indoor setting and room ventilation

Background Effective vaccines are now available for SARS-CoV-2 in the 2nd year of the COVID-19 pandemic, but there remains significant uncertainty surrounding the necessary vaccination rate to safely lift occupancy controls in public buildings and return to pre-pandemic norms. The aim of this paper is to estimate setting-specific vaccination thresholds for SARS-CoV-2 to prevent sustained community transmission using classical principles of airborne contagion modeling. We calculated the airborne infection risk in three settings, a classroom, prison cell block, and restaurant, at typical ventilation rates, and then the expected number of infections resulting from this risk at varying percentages of occupant immunity. Results We estimate the setting-specific immunity threshold for control of wild-type SARS-CoV-2 to range from a low of 40% for a mechanically ventilation classroom to a high of 85% for a naturally ventilated restaurant. Conclusions If vaccination rates are limited to a theoretical minimum of approximately two-thirds of the population, enhanced ventilation above minimum standards for acceptable air quality is needed to reduce the frequency and severity of SARS-CoV-2 superspreading events in high-risk indoor environments.

The Vaccination Threshold for SARS-CoV-2 Depends on the Indoor Setting and Room Ventilation

Background: Effective vaccines are now available for SARS-CoV-2 in the second year of the COVID-19 pandemic, but there remains significant uncertainty surrounding the necessary vaccination rate to safely lift occupancy controls in public buildings and return to pre-pandemic norms. The aim of this paper is to estimate setting-specific vaccination thresholds for SARS-CoV-2 to prevent sustained community transmission using classical principles of airborne contagion modeling. We calculated the airborne infection risk in three settings, a classroom, prison cell block, and restaurant, at typical ventilation rates, and then the expected number of infections resulting from this risk at varying levels of occupant susceptibility to infection. Results: We estimate the vaccination threshold for control of SARS-CoV-2 to range from a low of 40% for a mechanically ventilation classroom to a high of 85% for a naturally ventilated restaurant. Conclusions: If vaccination rates are limited to a theoretical minimum of approximately two-thirds of the population, enhanced ventilation above minimum standards for acceptable air quality is needed to reduce the frequency and severity of SARS-CoV-2 superspreading events in high-risk indoor environments.

Theoretical Minimum Detection Range for a Rapidly Moving Target and an Experimental Evaluation

There have been considerable challenges with radar systems for detecting high-speed projectiles at a short range. This necessitates the presentation of a guideline for the minimum detection range that will guarantee detection of a target. In this letter, the detection range for a rapidly flying target is studied based on the characteristics of the target, such as speed and launch angle, and radar parameters such as pulse repetition interval, dwell time, beamwidth, and so on. The derived equation was applied to parametric studies for different characteristics of targets in order to investigate the influential parameters that affect the minimum detection range. A field test using the radar system’s prototype was performed to evaluate the validity of the proposed equation.

How plants minimize somatic evolution

A remarkable property of plants is their ability to accumulate mutations at a very slow pace despite their potentially long lifespans, during which they continually form buds, each with the potential to become a new branch. Because replication errors in cell division represent an unavoidable source of mutations, minimizing mutation accumulation requires the minimization of cell divisions. Here we show that there exists a well defined theoretical minimum for the branching cost, defined as the number of cell divisions necessary for the creation of each branch. Most importantly, we also show that this theoretical minimum can be closely approached by a simple pattern of cell divisions in the meristematic tissue of apical buds during the generation of novel buds. Both the optimal pattern of cell divisions and the associated branching cost are consistent with recent experimental data, suggesting that plant evolution has led to the discovery of this mechanism.

Space- and computationally-efficient set reconciliation via parity bitmap sketch (PBS)

Set reconciliation is a fundamental algorithmic problem that arises in many networking, system, and database applications. In this problem, two large sets A and B of objects (bitcoins, files, records, etc.) are stored respectively at two different network-connected hosts, which we name Alice and Bob respectively. Alice and Bob communicate with each other to learn A Δ B , the difference between A and B , and as a result the reconciled set A ∪ B. Current set reconciliation schemes are based on either invertible Bloom filters (IBF) or error-correction codes (ECC). The former has a low computational complexity of O(d) , where d is the cardinality of A Δ B , but has a high communication overhead that is several times larger than the theoretical minimum. The latter has a low communication overhead close to the theoretical minimum, but has a much higher computational complexity of O(d 2 ). In this work, we propose Parity Bitmap Sketch (PBS), an ECC-based set reconciliation scheme that gets the better of both worlds: PBS has both a low computational complexity of O(d) just like IBF-based solutions and a low communication overhead of roughly twice the theoretical minimum. A separate contribution of this work is a novel rigorous analytical framework that can be used for the precise calculation of various performance metrics and for the near-optimal parameter tuning of PBS.