In this chapter, the author examines the obstacles that impede the flow of compassion in three directions: for others, from others, and from self. Obstacles to compassion for others include insecure attachment style, personal identity, self-interests, social dominance orientation, moral judgment, confusing compassion with submissiveness or weakness, empathy fatigue, time pressure, and scale of suffering (including psychophysical numbing, pseudo-inefficacy, and prominence effect). Obstacles to receiving compassion from others include activation of grief responses, perceived weakness, and vulnerability. The author also looks at what inner compassion is and how self-criticism hinders it. Finally, the author also discusses the barriers to compassion that are unique to the healthcare environment, including self-recrimination and self-neglect, empathic distress and empathy fatigue, moral suffering, bullying, burnout, medical culture, and cognitive scarcity.