Volumetric accuracy of different imaging modalities in acute intracerebral hemorrhage

Background Follow-up imaging in intracerebral hemorrhage is not standardized and radiologists rely on different imaging modalities to determine hematoma growth. This study assesses the volumetric accuracy of different imaging modalities (MRI, CT angiography, postcontrast CT) to measure hematoma size. Methods 28 patients with acute spontaneous intracerebral hemorrhage referred to a tertiary stroke center were retrospectively included between 2018 and 2019. Inclusion criteria were (1) spontaneous intracerebral hemorrhage (supra- or infratentorial), (2) noncontrast CT imaging performed on admission, (3) follow-up imaging (CT angiography, postcontrast CT, MRI), and (4) absence of hematoma expansion confirmed by a third cranial image within 6 days. Two independent raters manually measured hematoma volume by drawing a region of interest on axial slices of admission noncontrast CT scans as well as on follow-up imaging (CT angiography, postcontrast CT, MRI) using a semi-automated segmentation tool (Visage image viewer; version 7.1.10). Results were compared using Bland–Altman plots. Results Mean admission hematoma volume was 18.79 ± 19.86 cc. All interrater and intrarater intraclass correlation coefficients were excellent (1; IQR 0.98–1.00). In comparison to hematoma volume on admission noncontrast CT volumetric measurements were most accurate in patients who received postcontrast CT (bias of − 2.47%, SD 4.67: n = 10), while CT angiography often underestimated hemorrhage volumes (bias of 31.91%, SD 45.54; n = 20). In MRI sequences intracerebral hemorrhage volumes were overestimated in T2* (bias of − 64.37%, SD 21.65; n = 10). FLAIR (bias of 6.05%, SD 35.45; n = 13) and DWI (bias of-14.6%, SD 31.93; n = 12) over- and underestimated hemorrhagic volumes. Conclusions Volumetric measurements were most accurate in postcontrast CT while CT angiography and MRI sequences often substantially over- or underestimated hemorrhage volumes.

Solution of the Rodriguez Equation in Modeling Volumetric Geometric Accuracy of Multi-Coordinate Systems

The article describes the solution to the Rodrigues equation for determining the volumetric accuracy of multi-axis CNC-controlled systems. An algorithm for calculating the position of the axis of a rotary kinematic pair in problems of volumetric accuracy of mechanical motion of a portal-type system with an additional pair of rotation. The algorithm is based on the analytical solution of the Rodrigues equation in the inverse problem of finding the vector of the final rotation of the known modulus from the known initial and final values of the characteristic vector of the rotated rigid body. In contrast to the well-known direct problem, where based on a finite rotation vector known in direction and magnitude, and the initial value of the characteristic vector of a body, its final value is found, the inverse problem of the Rodrigues equation is not that common due to the nonlinearity and need to solve a nonlinear coupled system of second order equations. The results of this work make it possible to expand the dimension of the space of generalized coordinates of the system analyzed for the volumetric accuracy from three to four. This is expected contribute to the development of ultra-precise systems of controlled mechanical movement. The analytical results of this study were verified by comparing with numerical solutions of the inverse problem in Maple.

In vitro testing of the hemaPEN microsampling device for the quantification of acetaminophen in human blood

Background: The hemaPEN is a liquid microsampling device for the reproducible collection and storage of blood samples as dried blood spots, for subsequent quantitative analysis. Materials & methods: We examined the device’s ability to collect accurate and precise blood volumes, at different hematocrit levels, via in vitro studies using acetaminophen in human blood. We also investigated the impact of different user training approaches on device performance. Results: The hemaPEN demonstrated acceptable volumetric accuracy and precision, regardless of the training medium used. Issues with apparent hematocrit-dependent bias were found to be associated with the extraction process, rather than the volumetric performance of the device. Conclusion: The hemaPEN is capable of readily producing high quality blood microsamples for reproducible and accurate quantitative bioanalysis.

Experimental Study of the Volumetric Error Effect on the Resulting Working Accuracy—Roundness

Currently, various types of software compensations are applied to machine tools. Their aim is to increase the working accuracy of the tools. The improvement in working accuracy is then further assessed according to the increase in the dimensional and shape accuracy or the surface quality of the workpiece. This publication describes the effects of the volumetric accuracy of a machine tool on the working accuracy of a workpiece, where total roundness (RONt) is evaluated in multiple cuts. In the experiment, two test workpieces are manufactured on a three-axis milling machining centre. The first is made using a standard machine setup while the second with activated volumetric compensation. The LaserTRACER self-tracking laser interferometer is used to compensate for volumetric accuracy. In the second part, verification measurements are performed with a Ballbar, where roundness error is evaluated according to ISO 230-4. Then two test workpieces are machined, and, in the last part, measurement is performed on Talyrond 595S roundness measuring equipment. Finally, the results are analysed and the dependence between the volumetric accuracy, the circularity error of the machine and the working accuracy of the CNC machine tool is established, represented by the RONt of the workpiece. This paper presents new and unpublished relations between the volumetric accuracy of the machine tool and the RONt of the workpiece.