Metabolism-Repair (M,R) systems were concepts of relational biology which were rarely researched since Rosen wrote its foundations from 1958 and to his death, due to a lack of infatuation from the scientific community. We aim, in this article, to represent the effects of external factors on metabolic components, one of the main notions of (M,R) systems. We will firstly study the bases of (M,R) systems, then study the concepts of environment, external factors, tolerance, optimal values, efficiency, and time lags on metabolic components. We finally introduce the principle of eternal imperfectability of diverse biological systems, demonstrating how systems will never be perfect due to external factors acting upon metabolic components.