canine myocardial infarction
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2020 ◽  
Vol 46 (10) ◽  
pp. 2785-2800
Author(s):  
Vincent Sayseng ◽  
Rebecca A. Ober ◽  
Christopher S. Grubb ◽  
Rachel A. Weber ◽  
Elisa Konofagou

2019 ◽  
Vol 25 ◽  
pp. 3887-3893
Author(s):  
Buajieer-guli Nasi-Er ◽  
Xue Lou ◽  
Yinling Zhang ◽  
Huaxin Sun ◽  
Xianhui Zhou ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-10
Author(s):  
Jingjing Cui ◽  
Qing Deng ◽  
Qing Zhou ◽  
Sheng Cao ◽  
Nan Jiang ◽  
...  

Objective. This study aimed to develop a gene delivery system using ultrasound-targeted microbubbles destruction (UTMD) combined with nuclear localization signal (NLS) and investigate its efficacy and safety for therapeutic angiogenesis in canine myocardial infarction (MI) model. Methods. Fifty MI dogs were randomly divided into 5 groups and transfected with Ang-1 gene plasmid: (i) group A: only injection of microbubbles and Ang-1 plasmid; (ii) group B: only UTMD mediated gene transfection; (iii) group C: UTMD combined with classical NLS mediated gene transfection; (iv) group D: UTMD combined with mutational NLS mediated transfection; and (v) group E: UTMD combined with classical NLS in the presence of a nucleus transport blocker. The mRNA and protein expression of Ang-1 gene, microvessel density (MVD) cardiac troponin I (cTnI), and cardiac function were determined after transfection. Results. The expression of mRNA and protein of Ang-1 gene in group C was significantly higher than that of the other groups (all P < 0.01). The MVD of group C was 10.2-fold of group A and 8.1-fold of group E (P < 0.01). The cardiac function in group C was significant improvement without cTnI rising. Conclusions. The gene delivery system composed of UTMD and NLS is efficient and safe.


2008 ◽  
Vol 57 (3) ◽  
pp. 139-149 ◽  
Author(s):  
Takashi Yagi ◽  
Keiichi Fukuda ◽  
Jun Fujita ◽  
Jin Endo ◽  
Yasuyo Hisaka ◽  
...  

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