Relationship of cytokine levels with neuropsychological parameters in patients with vibration disease

Introduction. The results were obtained using the method of solid-phase enzyme immunoassay and neuropsychological examination of patients with vibration disease caused by the combined effect of local and general vibration. The aim of the study was to evaluate the relationship between the content of pro-and anti-inflammatory cytokines and changes in neuropsychological parameters in patients with vibration disease associated with combined exposure to local and general vibration. Materials and methods. Examined men were divided into groups: first group (n=28) - with vibration disease of the second degree, due to the combined effect of local and general vibration and the second (n=16) - the comparison group. There are methods of statistical analysis with the determination of the Shapiro-Wilk W-test, the Mann-Whitney U-test, and the Spearman correlation analysis. Results. In patients with vibration disease when compared to second group was higher values characterizing the analytic-synthetic (p=0.002) and conceptual thinking (p=0.016), short (verbal) (p=0.002), hand-shaped (p=0.002) and long (p=0.041) memory, dynamic (p=0.001) and constructive (p=0.001) praxis, visual gnosis (p=0,042), impressive speech (p=0.041), as well as index test, MMSE (p=0.003). Dysregulation in the immune system manifests in the form of a statistically significant hyperproduction of IL-8 and IFN-γ diagnosed in first group patients when compared with group II at p<0.05. There were statistically significant direct correlations between the concentration of IL-4 and the indicator of conceptual thinking, an indicator that characterizes finger gnosis (p=0.021; 0.025, respectively). Statistically significant dependences indicate that the increase in tests on the arithmetic triple score, the selection of opposites in the active plan, showing the specified finger on the sample and the name, an explanation of the logical-grammatical constructions, indicating a decrease in the function of analytical and synthetic thinking, conceptual thinking, finger gnosis, impressive speech, this is due to an increase in production of IL-8, IFN-γ (p=0,013; 0,044; 0,025; 0,008; 0,048; 0,046; 0,028; 0,018 respectively). Conclusions. The decrease in indicators that characterize analytical-synthetic, conceptual thinking, short-term (auditory-speech), long-term, operational visual memory, dynamic and constructive praxis, visual gnosis, and impressive speech is accompanied by hyperproduction of IL-8, IFN-γ. This fact may characterize the activation of the neuroinflammatory process as an important determinant of cognitive decline under the combined influence of local and general vibration. The established relationship between increased levels of IL-4 and indicators of conceptual thinking, visual gnosis, probably indicates the importance of more pronounced cytotoxic reactions in the violation of the mechanisms of visual perception and thought process in patients with vibration disease.

De nouvelles normes à l’égard des restes humains anciens : de la réification à la personnalisation?

The norms regarding human remains, old or new, are changing; we are witnessing unprecedented adjustments that tend to humanize these remains. Some of these, in very different contexts, are now treated as mortal remains and can benefit from treatment that could be qualified as funeral and lead to the cemetery. These changes are frequently interpreted as the result of the expression of ties (family ties, community affiliation) that promote a grieving process or a memory dynamic. However, a second trend is at work to apply principles dedicated to mortal remains, including the principle of human dignity, to human remains that have until now been reified. This trend can be observed at two levels, that of legal doctrine and that of practice. This article is based on an example from a recent preventive archaeological excavation, that captures both the issues and the responses adopted in situ about the trajectory and fate of these human remains.

Multi-Version-Pulsating STM: A Multi-Version Optimistic Concurrency Control Scheme for Highly Parallel in-Memory Workload in a Multi Core Environment

Large in-memory data structures have a significant application in the fields of graphics, gaming, military and all the possible areas where Big Data can be employed. Their fame in the area of science and technology is attributable to fast in-memory access by the processor as compared to on-disk data structures. These enormous data structures can be accessed still fast and efficiently through parallel computing. For employing highly parallel computations, equally parallel algorithms are required. One of the most desirable attributes of such algorithms is their ability to control concurrency and avoid any deadlocks while being time and energy efficient. This paper presents a multi-version optimistic concurrency control algorithm based on timestamping. This algorithm is lock free and is tested on 64 simulated CPU cores on a multi core simulator. The algorithm is a Software Transactional Memory approach employing 16, 32, 40 and 50 threads in different tests running on the simulator. Half of the threads are doing reading and half are doing writing operation in each case while accessing an in-memory dynamic array. Being lock free and employing lazy timestamp calculations, this approach is better than other existing concurrency control approaches.

Dynamic Resource Allocation of Heterogeneous Workload in Cloud

Circumnavigated enrolling is on intrigue relationship since it offers dynamic, adaptable and traditionalist resource isolate for strong and maintained relationship in remuneration as-you-use course to the customers. In Cloud arranging diverse cloud customers will request level of cloud benefits simultaneously, along these lines there should be a procedure that each one resources square measure made offered to referencing customer in valuable manner to satisfy their need while not picking the introduction of the focal points. Current IaaS fogs plan resources concerning virtual machines (VMs) with homogenous resource structures wherever isolating sorts of points of interest in VMs have proportionate segment of the cutoff in a strikingly physical machine (PM). Regardless, most customer businesses demand particularly astonishing wholes for various resources. for example, overwhelming selecting occupations need powerfully central processor thinks at any rate immense overseeing applications need additional memory. Dynamic point of confinement provisioning has changed into a promising response for decreasing centrality use in server creates starting late. a heterogeneity-careful structure that reasonably changes the proportion of machines to strike a cordiality between imperativeness save assets and booking delay