Combined Circumferential Canaloplasty and Trabeculotomy Ab Interno with the OMNI Surgical System

In the normal eye the conventional outflow pathway is responsible for the majority of aqueous humor egress and plays a key role in the maintenance of healthy intraocular pressure. However, in the glaucomatous eye pathologic changes to the pathway in the trabecular meshwork, Schlemm’s canal, and collector channel ostia can introduce abnormal resistance to outflow with consequent increase in intraocular pressure. The OMNI Surgical System (Sight Sciences, Menlo Park, CA USA) is a relatively new surgical device and the only one that combines two ab interno minimally invasive treatments in a single procedure, canaloplasty and trabeculotomy. This new technology allows surgeons to address outflow resistance wherever it may be, both proximally (juxtacanalicular trabecular meshwork and inner wall of Schlemm’s canal), and distally (Schlemm’s canal and the collector channels). This review covers several recent clinical studies of the OMNI device with the aim of collating what is known and what remains to be learned.

A Rare Complication of Hypermature Cataract Case Report

The hypermature senile cataract is an end stage in the process of age-related cataract formation. It can lead to numerous complications, and dislocation of the lens nucleus after spontaneous rupture is one of these complications, which is extremely uncommon. We report unusual case of spontaneous rupture of the lens capsule in a man with hypermature cataract, who presented to us with nucleus dislocation in the anterior chamber. It is important to highlight this uncommon cause of acute ocular hypertension.

Neonatal risk Factors and their Correlation with Severity and Stages of Retinopathy of Prematurity A Five Year Retrospective Study in a District General Hospital

Introduction: Retinopathy of prematurity is a largely preventable condition with appropriate screening and early intervention. A comprehensive study of risk factors and knowledge on the pathophysiology is of great importance to help clinicians predict high-risk patients. This paper aims to further identify risk factors of ROP and correlate them with different stages (severity) of ROP. Methods: A retrospective review of all preterm infants admitted to neonatal intensive care unit (NICU) in ELHT from January 2015 to December 2019. All infants screened and included were based on the screening criteria set out by the Royal College of Ophthalmologists. Results: Among 415 infants included, 199(48.0%) were male with gestational age of 28.90±2.72 weeks and mean birth weight of 1214.42±350.81g. The incidence of bilateral intraventricular haemorrhage (IVH) is higher in infants with stage 3 ROP (34.8%, P=0.002). Neonates who were Asian in ethnicity were more likely to have stage 3 ROP requiring laser treatment (60.9%, P=0.008; 66.7%, P=0.040). Units of blood transfusion and duration of ventilation were highly associated with severe ROP (5.26 ± 3.22, P<0.001; 31.13 ± 24.59, P<0.001) and ROP that required treatment (6.89 ± 6.17, P<0.001; 41.56 ± 37.02, P<0.001). Logistic regression analysis also revealed significant association between Asian ethnicity (OR: 0.289, CI:0.101-0.823), bilateral IVH (OR:1.895, CI:1.035-3.471), unit of blood transfusion (OR: 1.205, CI:1.028-1.413) with severe ROP and ROP requiring treatment. Conclusion: Bilateral IVH, units of blood transfusion, bronchopulmonary dysplasia, and Asian ethnicity are associated with severe ROP and ROP requiring treatment.

Nanomaterials in the Management of Contact Lens-Associated Ocular Complication

Contact lens is the transparent hemisphere-shaped ophthalmic product worn by a large population all across the globe for improving vision. It is applied to the cornea of the eye not only for improving vision but also for the delivery of drugs. The contact lens has many benefits but it also causes several ophthalmic infections which include amoebic keratitis, fungal, bacterial, and viral keratitis. The development of bacterial biofilm in lens cases exacerbates the ocular infection after the application of contact lenses in the cornea. Contact lens often associated with discomfort and dry eye. Coating these contact lens with different nanomaterials and an antimicrobial agent is a very good approach to improve the quality and biological activity of lenses. Surface functionalization is the most commonly adopted, and versatile method to tailor the optical properties. This review highlights the new technology to achieve the sustained release of drugs from contact lens by controlling their chemical, mechanical, and optical properties..