This essay concerns Dedekind’s “mathematical structuralism,”by which we mean methodological features characteristic for the approach to mathematics in his mature writings. The discussion starts with some background on forerunners, especially Gauss, Dirichlet, and Riemann, whose “conceptual” style of work influenced him strongly. But Dedekind went further than them, by making methodological choices that are more distinctly and fully “structuralist”. This includes his resolute acceptance of actually infinite systems, understood within a “logical” framework, and studied not just axiomatically, but also in terms of isomorphisms and related notions (since 1871). As an illustration, the essay discusses his early adoption and strikingly modern transformation of Galois theory, together with his contributions to algebraic number theory. After that, the essayturns to Dedekind’s more “foundational” contributions, i.e., his writings on the real numbers, the natural numbers, and set theory. It shows that the same methodological choices inform them. Yet his approach kept evolving in subtle ways too, especially in terms of the centrality of functions (Abbildungen, mappings).