Application of CLN-IgG/Pritumumab against COVID-19 Infectivity from the Aspect of Tumor-PIVIEMT Scheme

The touch/tactile sensor PIEZO1/2 and vimentin network is the critical conduit for COVID-19 virus infectivity. Coordination of PIEZO1/2 and vimentin network in regard to EMT/MET which is actual accordance of PIVEMT is critical for stem cell sustenance and wound healing of the injured cells and tissues in inflammation. On the contrary PIVIEMT discordance, deteriorated PIEZO1/2-Vimentin network, provokes pathogenic symptoms such as severe autoimmunopathies. From this aspect imminent treatment is necessary to recuperate the patients from onset of pathogens and/or neoplasms by use of chaperonic antibody that is able to restore/resile the pathogenic PIVIEMT as seen in the clinical trials against brain tumor patients with repetitive administration of the natural human monoclonal antibody CLN-IgG/Pritumumab. Targeting the virus conduit with the chaperonic antibody is highly expected for not only shutting down the virus infectivity but also augmentation of the antibody-directed vaccination against virus propagation.

Is Tumorigenesis an Abiogenesis?

CLN-IgG (Pritumuab) was subjected to clinical trials aiming at regression of brain tumors. The mechanism underlying the dramatic recuperation of cancer patient was considered by means of augmentation of idiotypic antibody-mediated internal image transmission of the vimentin epitope-vipidam. Silencing of prionogenicity of vimentin by chaperonic antibody CLN-IgG was a pertinent modality to elongate cancer patient's senescence with little side effect.