This chapter discusses 20th-century leprosy politics in Suriname in the context of a modernizing colonial state and in an era of ‘authoritarian high modernism’. Modern leprosy politics were a Janus head. On the one side, the politics were based on the latest developments and fashion in medical views on leprosy: sufferers should be treated as patients, not as criminals; medical treatment in asylums and in outpatient clinics should be encouraged; and a humane organization of life in the asylums should be promoted. However, unlike in other colonies, the idea of compulsory segregation was never abandoned. Sufferers with non-European backgrounds, especially the Afro-Surinamese and the British Indians, were still stigmatized and seen as unwilling or unable to cooperate. They had to be forced into segregation. On the other side of the Janus head, policies of surveillance, detection, and compulsory segregation were therefore intensified. A new edict of 1929 inaugurated a renewed era of increased detection and segregation of sufferers. By the 1940s, the colonial state claimed that leprosy was finally under control. However, this claim is doubtful.