Retinoic acid for gut health

2022 ◽  
Vol 15 (716) ◽  
Author(s):  
Annalisa M. VanHook
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Gut Health

Commensal-derived retinoic acid protects mice against infection by priming the innate defenses of intestinal epithelial cells.

Tu1402 All-Trans Retinoic Acid (ATRA) Stimulates SLC26A3 Activity in Intestinal Epithelial Cells via a PI3K Signaling Pathway

2015 ◽  
Vol 148 (4) ◽  
pp. S-880 ◽  
Author(s):  
Shubha Priyamvada ◽  
Arivarasu Natarajan Anbazhagan ◽  
Anoop Kumar ◽  
Tarunmeet Gujral ◽  
Alip Borthakur ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Signaling Pathway ◽  
Intestinal Epithelial Cells ◽  
Pi3k Signaling ◽  
Intestinal Epithelial ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Pi3k Signaling Pathway

scholarly journals Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages—Mechanisms and Targets

2020 ◽  
Vol 11 ◽  
Author(s):  
Celine Chen ◽  
Allen D. Smith ◽  
Lumei Cheung ◽  
Quynhchi Pham ◽  
Joseph F. Urban ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial

Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-γ-stimulated CXCL9–11 production in intestinal epithelial cells

2009 ◽  
Vol 123 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Shogo Kawaguchi ◽  
Yoh Ishiguro ◽  
Tadaatsu Imaizumi ◽  
Fumiaki Mori ◽  
Tomoh Matsumiya ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Ifn Γ ◽  
Inducible Gene

scholarly journals Benzoic Acid Used as Food and Feed Additives Can Regulate Gut Functions

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Xiangbing Mao ◽  
Qing Yang ◽  
Daiwen Chen ◽  
Bing Yu ◽  
Jun He
Keyword(s):  
Enzyme Activity ◽  
Epithelial Cells ◽  
Benzoic Acid ◽  
Intestinal Epithelial Cells ◽  
Redox Status ◽  
Feed Additives ◽  
Intestinal Epithelial ◽  
Gut Health ◽  
Food And Feed ◽  
Antibacterial And Antifungal

As a kind of antibacterial and antifungal preservative, benzoic acid is widely used in foods and feeds. Recently, many studies showed that it could improve the growth and health, which should, at least partially, be derived from the promotion of gut functions, including digestion, absorption, and barrier. Based on the similarity of gut physiology between human and pigs, many relative studies in which piglets and porcine intestinal epithelial cells were used as the models have been done. And the results showed that using appropriate benzoic acid levels might improve gut functions via regulating enzyme activity, redox status, immunity, and microbiota, but excess administration would lead to the damage of gut health through redox status. However, the further mechanisms that some intestinal physiological functions might be regulated are not well understood. The present review will, in detail, summarize the effect of benzoic acid on gut functions.

scholarly journals All-trans-retinoic Acid IncreasesSLC26A3DRA (Down-regulated in Adenoma) Expression in Intestinal Epithelial Cells viaHNF-1β

2015 ◽  
Vol 290 (24) ◽  
pp. 15066-15077 ◽  
Author(s):  
Shubha Priyamvada ◽  
Arivarasu N. Anbazhagan ◽  
Tarunmeet Gujral ◽  
Alip Borthakur ◽  
Seema Saksena ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134003 ◽  
Author(s):  
Kopperuncholan Namachivayam ◽  
Krishnan MohanKumar ◽  
Dima Arbach ◽  
Ramasamy Jagadeeswaran ◽  
Sunil K. Jain ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Retinoic Acid ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
P38α Mapk

scholarly journals Bifidobacterium breve UCC2003 induces a distinct global transcriptomic programme in neonatal murine intestinal epithelial cells

2020 ◽  
Author(s):  
Raymond Kiu ◽  
Agatha Treveil ◽  
Lukas C. Harnisch ◽  
Shabhonam Caim ◽  
Charlotte Leclaire ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epithelial Cells ◽  
Early Life ◽  
Intestinal Epithelial Cells ◽  
Stem Cell Marker ◽  
Control Group ◽  
Marker Genes ◽  
Intestinal Epithelial ◽  
Gut Health ◽  
Bifidobacterium Breve

SummaryBifidobacterium is an important gut microbiota member during early life that is associated with improved gut health. However, the underlying health-driving mechanisms are not well understood, particularly how Bifidobacterium may modulate the intestinal barrier via programming of intestinal epithelial cells (IECs). In this study, we sought to investigate the global impact of model strain Bifidobacterium breve UCC2003 on the neonatal IEC transcriptome, including gene regulation and pathway modulation. Small IECs from two-week-old neonatal mice administered B. breve UCC2003 for three consecutive days or PBS (control group) were subjected to global RNASeq, with various bioinformatic approaches used to determine differentially expressed genes, pathways and affected cell types between control and experimental groups. Whilst colonisation with B. breve had minimal impacts on the neonatal microbiota, we observed extensive regulation of the IEC transcriptome; ~4,000 genes significantly up-regulated, including key genes associated with epithelial barrier function. Enrichment of cell differentiation and cell proliferation pathways were observed, along with an overrepresentation of stem cell marker genes, indicating an increase in the regenerative potential of the epithelial layer. Expression of distinct immune-associated pathway members (e.g. Toll-like Receptors) were also affected after neonatal B. breve colonisation. In conclusion, B. breve UCC2003 plays a central role in driving universal transcriptomic changes in neonatal IECs that enhances cell replication, differentiation and growth, predominantly in the stem cell compartment. This study enhances our overall understanding of the benefits of B. breve in driving intestinal epithelium homeostatic development during early life, with potential avenues to develop novel live biotherapeutic products.

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