Is a History of Diabetes Mellitus Protective Against Developing Primary Open-angle Glaucoma?

2008 ◽  
Vol 126 (2) ◽  
pp. 280 ◽  
Author(s):  
Mae O. Gordon
Keyword(s):  
Diabetes Mellitus ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
History Of

scholarly journals EFFECT OF MYOPIA ON PRIMARY OPEN ANGLE GLAUCOMA

2020 ◽  
pp. 103-109
Author(s):  
MENAKURU SREYA REDDY ◽  
DIVYA N. ◽  
PANIMALAR A. VEERAMANI ◽  
BINDU BHASKARAN
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
High Myopia ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Age Group ◽  
Open Angle ◽  
Steroid Use ◽  
History Of ◽  
One Year

Objective: It is a retrospective study to evaluate the effect of myopia on primary open-angle glaucoma by classifying the eyes into NMG (non-myopic glaucoma), HMG (highly myopic glaucoma) And MMG (mild to moderate myopic glaucoma). Methods: The study was performed on 120 patients with primary open-angle glaucoma who were medically treated. Any participant who had surgery done was excluded from the study. The relation between glaucoma and different myopia and progression were assessed on the basis of age, gender, risk factors. Results: Out of the 120 cases assessed, 46 [38 percent] were female and 74 [62 percent] were males. On the basis of age there were 9 cases between 31-40 y, 30 cases between the ages 41-50, 40 cases between 51-60, 32 cases between 61-70 and 9 cases between 71-80, on the basis of myopia 59 [49 percent] were NMG 47 [39 percent] were MMG and 14 [12 percent] were HMG. On the basis of risk factors,12 of them had Diabetes Mellitus, 7 had Hypertension, 7 had a history of steroid use, 3 had a history of migraines and 6 of them had a family history of glaucoma. In the observed one year period 73 percent if the cases were not progressive while 27 percent were progressive. In this study, it has been observed that the males are more commonly affected and the age group with the most cases was the 51 to 60 age group. The majority of the cases showed no risk factors though Diabetes Mellitus is the most common. The progression of the disease is seen more frequently in cases associated with Diabetes Mellitus and Hypertension. In MMG 12 out of the 47 cases were progressive and in NMG 15 out of the 59 cases were progressive. Conclusion: Though high myopia is important in the pathogenesis of glaucoma there was no evidence that high myopia increases the progression of the disease of the 14 cases, only 5 were progressive.

scholarly journals Risk factors of primary open-angle glaucoma: the first case-control hospital-based study in Vietnam

2019 ◽  
Author(s):  
Anh Van Bui ◽  
Tung Thanh Hoang ◽  
Ngoc Bich Nguyen ◽  
Anh Kim Le ◽  
Jennifer L. Patnaik
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Open Angle ◽  
Over The Counter ◽  
Vietnamese Population ◽  
History Of

Abstract Purpose: To identify risk factors for primary open-angle glaucoma (POAG) in a Vietnamese population. Methods: A matched case-control study was conducted at Vietnam National Institute of Ophthalmology. Cases were patients clinically diagnosed with POAG. Controls were caregivers of patients with other eye diseases, free from any ocular and systemic abnormalities, and were selected and then matched with the cases by gender and age. Cases and controls were examined by a glaucoma specialist to confirm presence or absence of POAG. Data on demographic, ophthalmic and medical conditions were collected via interview at time of examination. Associations between POAG and potential factors were examined by univariate conditional logistic regression analysis (OR – Odd Ratios) and multivariate conditional logistic regression (AOR – Adjusted Odd Ratios) with level of significance is 0.05. Results: In total, 128 cases with POAG and 128 controls were recruited. Multivariate conditional (fixed-effects) logistic regression analysis resulted in several significant risk factors, including hypertension AOR =4.7 (95% CI: 1.8–12.0; p=0.002); family history of glaucoma AOR = 6.4 (95% CI: 1.3 – 32.2; p = 0.026); over–the–counter eye medication AOR = 3.1 (95% CI: 1.5 – 6.5; p = 0.006), and a protective role for marriage AOR = 0.2 (95% CI: 0.1 – 0.7; p = 0.006) and weekly exercise AOR = 0.3 (95% CI: 0.1 – 0.8; p = 0.021). Conclusions: Hypertension, family history of glaucoma and over–the–counter eye medication were risk factors while marriage and weekly exercise were protective factors for POAG in Vietnamese population.

scholarly journals Glaucoma Primário de Ângulo Aberto e Diabetes Mellitus: uma revisão sistemática de aspectos anatômicos e genéticos/ Primary Open-Angle Glaucoma and Diabetes Mellitus: a systematic review of anatomic and genetic aspects

2020 ◽  
Vol 3 (6) ◽  
pp. 19510-19522
Author(s):  
Marcelo Caetano Hortegal Andrade ◽  
Alexandre de Magalhães Marques ◽  
Edla Mayara Fernandes Vaz ◽  
Suéllem Crystina de Siqueira Paiva dos Santos ◽  
Suellen de Castro Lima ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

scholarly journals Factors Related to Superior and Inferior Hemifield Defects in Primary Open-Angle Glaucoma

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Remi Takeuchi ◽  
Nobuko Enomoto ◽  
Kyoko Ishida ◽  
Ayako Anraku ◽  
Goji Tomita
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Defect Group ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Contributing Factors ◽  
Fiber Layer ◽  
Defect Groups ◽  
Disc Area ◽  
History Of

Purpose. We aimed to investigate factors related to superior and inferior hemifield defects in primary open-angle glaucoma (POAG). Methods. Sixty-seven subjects with newly diagnosed, untreated POAG underwent optical coherence tomography (OCT) of the disc area, macular ganglion cell complex (mGCC), and circumpapillary retinal nerve fiber layer (cpRNFL) thickness within 6 months of the visual field (VF) test. Based on the VF and OCT results, 40 subjects had a superior and 27 an inferior hemifield defect. Clinical data including visual acuity, refractive error, disc hemorrhage, VF indexes, and medical history were recorded. Results. Average mGCC thickness corresponding to the defective hemifields was thinner in the superior VF defect group than in the inferior VF defect group (P=0.003). Average total deviation (TD) was comparable between the two groups. However, the superior VF defect group had a higher prevalence of defects (P=0.001) and lower TD (P=0.002) within central 5 degrees of VF than the inferior VF defect group. In multivariate regression analyses, the temporal-lower and inferior-temporal cpRNFL thicknesses were significant contributing factors to the inferior mGCC thickness in the superior VF defect group. In the inferior VF defect group, the disc area, family history of glaucoma, and temporal-upper cpRNFL thickness contributed to the superior mGCC thickness. Conclusion. The inferior mGCC thickness corresponding to the superior hemifield defect group was significantly thinner than the superior mGCC thickness corresponding to the inferior hemifield defect group. The factors related to the reduction of the corresponding mGCC thickness may differ between superior VF defect and inferior VF defect groups.

Features of Diabetic Retinopathy Combined with Type 2 Diabetes Mellitus and Primary Open-Angle Glaucoma

2021 ◽  
pp. 85-96
Author(s):  
K. A. Gudzenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Disease Rate ◽  
Open Angle ◽  
Statistical Research

Relevance. Common mechanisms of pathogenesis of diabetic retinopathy (DR) with type 2 diabetes mellitus (DM2) and glaucoma optic neuropathy (GON) with primary open-angle glaucoma (POAG) involve the possibility of their mutual clinical burden. The aim. To explore the features of the combination of DR in DM2 and POAG in terms of progression of the stages of the pathological process. Material and methods. 546 patients were examined (546 eyes): 301 patients (301 eyes) had DM2 and POAG; 164 patients (164 eyes) had DM2 and DR, but did not have POAG; 81 patients (81 eyes) had POAG, but did not have DM2. The DR stage was established according to the American Academy of Ophthalmology classification (2002); POAG stage was determined according to the classification of perimetric changes. Some patients were diagnosed with normal tension glaucoma (NTG; 72 eyes). The DR and GON progression indices in patients with POAG were calculated on the basis of the stage and the duration of the diseases and the patients’ age. The software used for statistical research: MedStat і MedCalc v.15.1 (MedCalc Software bvba). Results. The DR progression (by the ratio of the DR stage to the duration of the DM2) at various combinations with POAG had no significant differences. It increased only when NTG was combined with DM2. GON progression was higher when POAG was combined with DM2. In case of DM2 combined with POAG, the progression of GON was as follows. In the case of its primary development, it was higher in NTG, and when it was connected to DM2 – in POAG. The disease index (the ratio of the primary disease rate to age) was the highest when DM2 was combined with POAG, which made the progression of GON 1.2 times faster (p=0.001). The duration of comorbidity in the POAG + DM2 group was 3-4 years more than in DM2 + POAG and NTG + DM2 groups (p<0.001). No gender differences in the DR and GON progression were found. Conclusions. The studied characteristic of the combination of DR with DM2 and POAG revealed complex and ambiguous mechanism of their possible interaction, which dictates the need for further investigation of the mechanisms of their comorbidity. Keywords: diabetic retinopathy, type 2 diabetes mellitus, primary open-angle glaucoma, comorbidity.

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