Serum Creatinine Level and Renal Function in Children

1992 ◽  
Vol 146 (10) ◽  
pp. 1232 ◽  
Author(s):  
James E. Springate
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level

Endovascular Treatment of Transplant Renal Artery Stenosis: A Systematic Review and Meta-analysis

2021 ◽  
pp. 152660282110385
Author(s):  
David Eugenio Hinojosa-Gonzalez ◽  
Gustavo Salgado-Garza ◽  
Mauricio Torres-Martinez ◽  
Sergio Uriel Villegas-De Leon ◽  
Luis Carlos Bueno-Gutierrez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Renal Function ◽  
Serum Creatinine ◽  
Renal Artery ◽  
Serum Creatinine Level ◽  
Endovascular Treatment ◽  
Renal Artery Stenosis ◽  
Creatinine Level ◽  
Mean Difference ◽  
Artery Stenosis

Objective Endovascular treatment through either percutaneous transluminal angioplasty (PTA) alone or stenting has been previously used as a treatment for transplant renal artery stenosis (TRAS). This review aimed to investigate the results of endovascular treatment for renal artery stenosis in transplanted kidneys as compared with the outcomes of interventions, medical management, and graft survival in non-TRAS patients. Methods A systematic review of PubMed, Google Scholar, Cochrane, and Scopus was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines in which studies that reported outcomes of the treatment of TRAS via the endoluminal approach were identified, and their results were meta-analyzed. Results Fifty-four studies with a total of 1522 patients were included. A significant reduction of serum creatinine level was found, favoring the stenting group, with a mean difference of 0.68 mg/dL (95% confidence interval (CI), 0.17–1.19; Z=2.60, p=0.0009). Comparison of pre- and post-intervention values of any intervention revealed a significant decrease in overall serum creatinine level (0.65 mg/dL; 95% CI, 0.40–0.90; Z=5.09, p=0.00001), overall blood pressure, with a mean difference of 11.12 mmHg (95% CI, 7.29–14.95; Z=5.59, p=0.00001), mean difference in the use of medications (0.77; 95% CI, 0.29–1.24; p=0.002), and peak systolic velocity (190.05; 95% CI, 128.41–251.69; p<0.00001). The comparison of serum creatinine level between endovascular interventions and best medical therapy favored endovascular intervention, with a mean difference of 0.23 mg/dL (95% CI, 0.14–0.32; Z=5.07, p<0.00001). Graft survival was similar between the treated patients and those without TRAS (hazard ratio, 0.98; 95% CI, 0.75–1.28; p=0.091). The overall pooled success rate was 89%, and the overall complication rate was 10.4%, with the most prevalent complication being arterial dissection. Conclusion The endovascular treatment of TRAS improves graft preservation and renal function and hemodynamic parameters. PTA + stenting appears to be a more effective option to PTA alone in the stabilization of renal function, with additional benefits from decreased restenosis rates. Further high-quality studies could expand on these findings.

scholarly journals Prognosis of obstructive nephropathy patients after percutaneous nephrostomy

2015 ◽  
Vol 22 (1) ◽  
Author(s):  
Jefri Sukmagara ◽  
H R Danarto
Keyword(s):  
Logistic Regression ◽  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Obstructive Uropathy ◽  
Percutaneous Nephrostomy ◽  
Symptom Duration ◽  
Multiple Logistic Regression ◽  
The Relationship

Background: Percutaneous nephrostomy is a life-saving procedure for the treatment of obstructive uropathy associated with septicaemia and uraemia. It is regarded as a temporary interventional procedure before definitive treatment. Several factors can affect recovery of renal function after nephrostomy, such as patient age, duration of obstruction, function of the contralateral kidney, pyelolymphatic backflow and compliance of the ureter and renal pelvis.Objective: To determine factors that can predict the decrease in creatinine levels after percutaneous nephrostomy (< 2mg/dl).Methods: This is a retrospective analysis descriptive study. All patients previously performed nephrostomy at Sardjito General Hospital Yogyakarta, from January 2009 to December 2012 were identified. The data were analyzed to evaluate the relationship between reduction of serum creatinine level and following variables including: etiology, nephrostomy (unilateral or bilateral), symptom duration (≤14 days or >14 days), comorbid disease (hypertension, diabetes melitus, heart disease) and degree of hydronephrosis (mild, moderate and severe). The data were analyzed with Chi-Square test and multiple logistic regression to obtain predictive factor and predictive scoring equation to measure the possibility of recoverability of renal function after nephrostomy.Results: We analyzed 117 patients that previously treated by percutaneous nephrostomy. It showed the relationship between reduction of serum creatinine level and the following variables:  nephrostomy (unilateral or bilateral) (p=0,000), symptom duration (p=0,000), hypertension (p=0,004) and degree of hydronephrosis (p=0,000). Whereas etiology of urinary obstruction and other comorbid diseases showed no relationship. Predictive equation result: P= 1/(1+ey), where y= -0,271 + 1,636 (degree of hydronephrosis) + ((-2,216) unilateral or bilateral nephrostomy) + 1,694 (symptom duration) + ((-0,862) hypertension), with sensitivity 74,3% and specificity 70,7% in predicting renal function recoverability.Conclusions: Bilateral or unilateral nephrostomy, symptom duration, hypertension and degree of hydronephrosis are factors affecting the decrease in serum creatinine level. They role as independent predictor to predict recoverability of renal function can be considered. Key words: obstructive uropathy, percutaneous nephrostomy, multiple logistic regression.

RENAL FUNCTION AND CLINICAL PROFILE IN CHILDREN WITH CONGENITAL HEART DISEASE – AN OBSERVATIONAL STUDY FROM TERTIARY CARE HOSPITAL IN CENTRAL INDIA.

2021 ◽  
pp. 8-10
Author(s):  
Tulsi Devi Dhurvey ◽  
Ghanshyam Das ◽  
Ajay Gaur ◽  
Satvik Bansal
Keyword(s):  
Socioeconomic Status ◽  
Congenital Heart Disease ◽  
Renal Function ◽  
Heart Disease ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Urine Output ◽  
Congenital Heart ◽  
Cleft Lip

Purpose: To evaluate the renal function and clinical prole in children with congenital heart disease. Method: After taking informed consent from the parents of 118 children aged 1 month to 14 years were recruited in study. Anthropometry and vitals were noted. Complete physical examination and USG abdomen done to identify any other associated congenital anomaly. Laboratory evaluation of serum creatinine was done on day 1 and day 5. 24 hours urine output was strictly measured till day 5 of admission. Result: The maximum number of cases belonged to age group 1-6 month. Male children were affected more than females (1.5:1) and majority of the children belong to family of lower middle and lower socioeconomic status. Most of the children belong to rural area. Among syndromic features, microcephaly and cleft lip and cleft palate were most frequently observed. Most of the cases had weight /height <-3SD. There was no major signicant difference in mean value of urine output and serum creatinine level in different age groups and in between cyanotic and acyanotic group. Conclusion: Congenital heart disease forms a significant diagnosis in hospitalized children. Larger studies are needed to evaluate newer associations (like male gender and low socioeconomic status). Microcephaly and cleft lip/palate were most observed associated syndromic features. No signicant effect was observed on the mean urine output and serum creatinine level in children with congenital heart disease.

scholarly journals Kidney histotexure and serum creatinine level in response to concurrent administration of alcohol and coffee in mice

2016 ◽  
Vol 32 (2) ◽  
pp. 42-47
Author(s):  
MT Islam ◽  
MK Islam ◽  
MZ Hossain ◽  
MA Wares
Keyword(s):  
Drinking Water ◽  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Control Group ◽  
Pathological Changes ◽  
Concurrent Administration ◽  
Group A ◽  
High Doses

The effect of alcohol and coffee on renal function with pathological changes in kidney was determined in mice. Sixty Albino mice were randomly divided into six equal groups. The mice of group A were maintained as control and remaining five groups were used as treated groups. The mice of control group were supplied with normal mice pellets whereas other groups were supplied with same pellets in addition to 5% coffee (in drinking water), 10% coffee, 10% alcohol, 5% coffee plus 5% alcohol and 10% coffee plus 10% alcohol, for 90 days. The serum creatinine level was significantly (P<0.01) higher in groups supplied with alcohol. There was huge infiltration of reactive cells and mild haemorrhagic spots in kidney of mice that received 10% coffee and 10% alcohol, respectively. It is suggested that long use of high doses of alcohol and coffee impaired kidney function.Bangl. vet. 2015. Vol. 32, No. 2, 42-47

scholarly journals GIANT HYDRONEPHROSIS

2012 ◽  
Vol 19 (04) ◽  
pp. 546-548
Author(s):  
NISAR AHMED SHAIKH ◽  
GHULAM SHABIR SHEIKH ◽  
SHABIR AHMED LARIK ◽  
Muhammad Iqbal ◽  
MALIK Hussain
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Clinical Presentation ◽  
Renal Stones ◽  
Elevated Blood ◽  
Early Referral ◽  
Giant Hydronephrosis ◽  
Definitive Surgery

Objective: To study the clinical presentation and management of giant hydronephrosis. Setting: Civil Hospital Dadu andUrology Department SMBBMU Larkana. Period: March 2004 to march 2011. Patients and methods: 28 Patient with giant hydronephrosistreated. 18(64.3%) patients had unilateral and 2(7.1%)had bilateral pelvi ureteric junction obstruction, 4(14.3%) had ureteric stones andremaining 4(14.3%) had multiple renal stones. All patients were treated with definitive surgery ie pyeloplasty, nephroplication, ureterolithotomy,extended pyelolithotomy and nephrectomy. Six (21.4%) patients had elevated blood urea and serum creatinine level so initially treated bypercutaneous nephrostomy and ureteric cathetrization. Result: 10 out of 28 cases of giant hydronephrosis showed improvement in the functionand drainage as well as pelvi-calyceal system dilatation while 18 patients going for nephrectomy. Conclusions: Early referral and interventionis necessary for giant hydronephrosis to prevent infection and deterioration of renal function.

scholarly journals Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Takuya Murakami ◽  
Tetsu Akimoto ◽  
Mari Okada ◽  
Erika Hishida ◽  
Taro Sugase ◽  
...  
Keyword(s):  
Elderly Patient ◽  
Acute Kidney Injury ◽  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Kidney Injury ◽  
Blood Purification ◽  
Standard Dosage ◽  
History Of

A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0.68 mg/dL. We feel that awareness of this pathology remains a challenge for physicians and therefore strongly recommend the further accumulation of experiences similar to our own. Our experience underscores the pitfalls of administering valacyclovir to elderly patients who barely appear to have a favorable renal function. Several concerns regarding the therapeutic management, including blood purification strategies, that emerged in this case are also discussed.

Abstract 15174: Higher Plasma Osmolality as an Independent Determinant of In-hospital Worsening Renal Function in Acute Decompensated Heart Failure

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Tetsufumi Motokawa ◽  
Toshiyuki Nagai ◽  
Yasuo Sugano ◽  
Takafumi Yamane ◽  
Tatsuhiro Shibata ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Acute Decompensated Heart Failure ◽  
Plasma Osmolality ◽  
Decompensated Heart Failure ◽  
Worsening Renal Function ◽  
Independent Determinant

Backgrounds: Previous studies showed that worsening renal function (WRF) was associated with poor clinical outcome in acute decompensated heart failure (ADHF) patients. Hyperosmolarity is known to cause direct renal cell injury and decreases in renal blood flow and glomerular filtration rate. In ADHF setting, the plasma osmolality can be changed dramatically. However, the prognostic significance of plasma osmolality for the development of WRF in ADHF patients is unclear. Methods: We examined 320 consecutive ADHF patients who admitted to our institution between January 2013 and January 2014 from prospective registry. Patients who had acute coronary syndrome and without complete data-set at admission were excluded. Finally, 303 patients were divided into two groups according to lower plasma osmolality (below 297 mOsm/kg H2O, the cut-off value based on ROC analysis) or higher plasma osmolality (above 297 mOsm/kg H2O) at admission. WRF was defined as ≥ 0.3 mg/dl increase in serum creatinine from baseline to discharge. Results: During follow-up period (median 21 days, interquartile range 14-29), WRF was occurred in 58 patients (19.6 %). Patients with higher plasma osmolality had significantly higher incidence of WRF compared with those without (32.3% vs 13.6%, P<0.01). Higher plasma osmolality was associated with more use of diuretics, higher serum creatinine level and lower hemoglobin level. There were no significant differences between the two groups in terms of age, sex, body mass index, NYHA functional class, left ventricular ejection fraction (LVEF), blood pressure, etiology of HF, cardiovascular medications other than diuretics, plasma brain natriuretic peptide (BNP) level on admission. Multivariate logistic regression analyses showed that higher plasma osmolality (OR 2.00, 95% CI 1.00-3.98, P=0.049), as well as lower hemoglobin (OR 1.22, 95% CI 1.04-1.42, P=0.012), was an independent determinant of WRF, although other variables including age, sex, serum creatinine level and use of diuretics on admission were not. Conclusions: In patients with ADHF, higher plasma osmolality on admission was an independent predictor of in-hospital WRF, suggesting the measurement of plasma osmolality might be useful for identifying patients at risk for WRF.

Renal involvement in diffuse aggressive lymphomas: results of treatment with combination chemotherapy.

1985 ◽  
Vol 3 (5) ◽  
pp. 646-653 ◽  
Author(s):  
D B Geffen ◽  
R I Fisher ◽  
D L Longo ◽  
R C Young ◽  
V T DeVita
Keyword(s):  
Renal Function ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Combination Chemotherapy ◽  
Normal Renal Function ◽  
Systemic Disease ◽  
Renal Involvement ◽  
Elevated Serum ◽  
Aggressive Lymphoma

Nine (5.1%) of 175 patients with advanced disseminated diffuse aggressive non-Hodgkin's lymphoma presented with renal involvement and were initially treated with combination chemotherapy alone. These patients were classified as having renal involvement based on histologic and radiographic criteria. Five of the nine patients presented with a serum creatinine level greater than 2.5 mg/dL. Four patients achieved a complete remission of all systemic disease. Eight patients had complete resolution of renal involvement. Two patients later had recurrent renal disease associated with other sites of recurrence. All five patients who presented with an elevated serum creatinine level recovered normal renal function; in fact, four patients had normal renal function by the end of the first cycle of therapy. No patient required hemodialysis. Only one patient remains alive and free of disease at 55 months; five patients have died with disseminated disease; two patients have died without evidence of disease; and one patient was lost to follow-up while in remission. Initial local control of renal involvement including normalization of renal function in diffuse aggressive lymphoma can be rapidly achieved by combination chemotherapy alone.

scholarly journals Correlation of renal function tests with early onset neonatal sepsis.

2020 ◽  
Vol 27 (02) ◽  
pp. 317-323
Author(s):  
Amna Iqtidar ◽  
Imran Ali ◽  
Aamer Naseer ◽  
Fouzia Aamer ◽  
Kiran Namoos ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Serum Creatinine ◽  
Serum Creatinine Level ◽  
Creatinine Level ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Function Tests ◽  
Renal Function Tests

Early onset neonatal sepsis is invariably very common and serious problem worldwide, especially it is one of the important etiological factor for deaths of neonates in Pakistan. Acute renal failure is frequently seen in neonates with sepsis. Objectives: The aim of present study was to determine the correlation of renal function tests (Blood Urea and creatinine) with early onset neonatal sepsis. Study Design: Descriptive study. Setting: Department of Paediatric Medicine Sir Ganga Ram hospital, Lahore. Period: Six months from 20th March to 20th September 2018. Material & Methods: Total 300 cases of neonatal sepsis with acute renal failure were included in this study after taking informed consent from the parents. Cases selection was done with help of a predefined inclusion and exclusion criteria. Daily blood urea and serum creatinine were calculated from birth to first 7 days of life. If any of blood urea or serum creatinine was deranged, the neonate was labelled as having acute renal failure. Data was entered and analysed using SPSS software version 21. Results: Mean age of all cases was 2.82±1.56 days. The minimum and maximum age limits of the neonates were 1 and 7 days respectively. Gender distribution of neonate showed that 57% of the neonates were male and 43% were females. At the 2nd day of life, mean serum creatinine level was 1.12±0.39, at 3rd day 1.19±0.51, at 4th day 1.41±0.38, at 5th day 1.33±0.39, at 6th day 1.19±0.39, and at 7th day mean serum creatinine level was 1.09±0.31 respectively. At 2nd day of birth mean blood urea was 54.82±34.77, at 3rd day59.50±28.22 at 4th day 74.94±30.37, at 5th day 67.09±26.94, at 6th day 56.09±25.76, at 7th day mean blood urea level was 47.66±22.47 respectively. Frequency of acute renal failure was observed in 28.3% of the neonates while the remaining 71.7% of neonates did not suffer from acute renal failure. Conclusion: Early onset neonatal sepsis contributes significantly to development of acute renal failure in neonates.

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