Endocrine Influences on Fat and Carbohydrate Metabolism in Man: II. Effect of Sulfonylurea Derivatives on Abnormalities of Serum Nonesterified Fatty Acid and Blood Glucose Concentration in Diabetes Mellitus

JAMA ◽  
1963 ◽  
Vol 183 (6) ◽  
pp. 233
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Carbohydrate Metabolism ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Nonesterified Fatty Acid

Can the diabetic diet be improved?

1979 ◽  
Vol 17 (22) ◽  
pp. 85-87
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Cardiovascular Complications ◽  
Fibre Content ◽  
Dietary Control ◽  
Carbohydrate Restriction ◽  
Hypoglycaemic Agents ◽  
Diabetic Diet

Dietary control is a central part of management of diabetes mellitus. Traditional advice is primarily concerned with carbohydrate restriction, calorie control and the timing of meals. The importance of the fat and fibre content is largely ignored although fats might influence the development of cardiovascular complications and fibre the blood glucose concentration and the response to hypoglycaemic agents. The composition of the diabetic diet needs reappraisal.

THE EFFECTS OF HORMONES ON THE CARBOHYDRATE METABOLISM OF THE LAMPREY LAMPETRA FLUVIATILIS

1965 ◽  
Vol 31 (2) ◽  
pp. 127-137 ◽  
Author(s):  
P. J. BENTLEY ◽  
B. K. FOLLETT
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Carbohydrate Metabolism ◽  
Glucose Concentration ◽  
Skeletal Muscles ◽  
Blood Glucose Concentration ◽  
Liver Glycogen ◽  
Arginine Vasotocin ◽  
Glycogen Concentration ◽  
Muscle Glycogen Concentration

SUMMARY River lampreys regulated their blood glucose concentration when injected with glucose. Mammalian insulin decreased the blood glucose concentration in the lamprey while adrenaline, cortisol and arginine vasotocin increased it. Glucagon had no effect initially but after a delay of 4 hr. decreased the blood glucose level. Insulin and cortisol increased the liver glycogen concentration. Adrenaline decreased the muscle glycogen concentration; vasotocin increased it. Treatment with alloxan increased the blood glucose concentration. Fat and glycogen in the lamprey are stored mainly in the skeletal muscles and their histochemical distribution in muscle is described. The results are discussed in relation to the metabolism of the migrating lamprey and the evolution of the control of carbohydrate metabolism in vertebrates.

scholarly journals Pengaruh substitusi fodder jagung pada silase rumput alam terhadap konsumsi dan kecernaan serat, konsentrasi VFA dan kadar glukosa darah pada pedet jantan sapi persilangan ongole x brahman lepas sapih

2020 ◽  
Vol 7 (1) ◽  
pp. 63-74
Author(s):  
Sefrans Banamtuan ◽  
I Gusti Ngurah Jelantik ◽  
G. A. Y. Lestari
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Acid Concentration ◽  
Glucose Concentration ◽  
Volatile Fatty Acid ◽  
Blood Glucose Concentration ◽  
Fiber Intake ◽  
Grass Silage ◽  
Fiber Digestibility ◽  
Volatile Fatty Acid Concentration

The objective of this experiment was to evaluate the effect of corn fodder on intake and fiber digestibility, volatile fatty acid and blood glucose concentration  of weaned Ongole x Brahman calves. This experiment followed a 4x4 latin square design with four treatments, i.e. G : 100% nature grass silage, GCF1 : 35% nature grass silage, 35% corn fodder silage and 30% concentrate, GCF2 : 17,5% nature grass silage, 52,5% corn fodder and 30% concentrate, GCF3 : 70% corn fodder and 30% concentrate. The measured variables included fiber intake and digestibility, volatile fatty acid and blood glucose concentration. Data were subjected to Analysis of Variance (Anova) followed by Duncan Multiple Range Test to separate between means with SPSS 21. Result showed that fiber intake was significantly (P<0,05) lower in GCF3 (299,88 g.d-1) compared to the other treatments which varied between 661,55 to 1293,95 g.d-1. Fiber digestibility, however, did not differ (P>0,05) between treatments, i.e. varied between 55,95 to 72,65%. Volatile Fatty Acid concentration increased (P<0,05) with the increasing  levels substitutions of corn fodder in feed. The treatments did not affect (P>0,05) blood glucose concentration of Ongole calves. It can be concluded that substitution of corn fodder for native grass silage has significant effect on fiber intake and Volatile Fatty Acid concentration but not on fiber digestibility and blood glucose  concentration of weaned cross Ongole calves.

scholarly journals Syzygium polyanthum protects against diabetic cardiac apoptosis in the chronic diabetes mellitus

2020 ◽  
Vol 5 (1) ◽  
pp. 16
Author(s):  
Flori R Sari ◽  
Hari Hendarto ◽  
Chris Adhiyanto ◽  
Fadhlurrahman Ananditya ◽  
Irfiani N ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Cholesterol Concentration ◽  
Diabetic Rat ◽  
Beneficial Role ◽  
Cell Death Pathway ◽  
Cardiac Apoptosis ◽  
Persistent Hyperglycemia

Introduction: Hyperglycemia has become the main characteristic of diabetes mellitus. Persistent hyperglycemia directly activates cell death pathway that plays pivotal role in the diabetic complication including diabetic cardiomyopathy. Syzygium polyanthum plays a beneficial role in the diabetic condition by reducing the blood glucose concentration, however the role of this natural resources in preventing further complication of diabetes mellitus has not been revealed fully yet.Method: Syzygium polyanthum dry extract (300 mg/kg body weight) were given daily for 28 days in the streptozotocin-induced diabetic rat. Measurement of blood glucose concentration were done three times during the study, meanwhile cholesterol concentration, myocardial diameter and cardiac apoptosis were measured on the day 28 of the study. Cardiac apoptosis was analyzed by the TdT-mediated dUTP nick end-labelling (TUNEL Assay).Results: Persistent hyperglycemia as well as cardiac apoptosis was significantly observed in the diabetic rat (D) on the day 28 of the study confronted to the normal rat (N). Interestingly, significant blood glucose reduction in concomitant with a lesser concentration of cardiac apoptosis were observed in the diabetic rat received 28 days Syzygium polyanthum extract (DS) confronted to the D rat. Additionally, lower plasma cholesterol concentration was significantly observed in the DS rat confronted to the D rat.Discussion: Significant cardiac apoptosis was observed in consistent with persistent hyperglycemia in the D rat as well as lesser cardiac apoptosis was observed in accordance with blood glucose concentration reduction in the DS rat. Therefore, Syzygium polyanthum may play beneficial role in the diabetic-associated cardiac apoptosis through its direct effect on the blood glucose concentration reduction. However further analysis should be done to fully elucidate the apoptotic pathway that involved.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 16-21

Production of diabetes mellitus in the duck by insulin antibodies

1964 ◽  
Vol 206 (1) ◽  
pp. 133-135 ◽  
Author(s):  
I. Arthur Mirsky ◽  
Robert Jinks ◽  
Gladys Perisutti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Intravenous Injection ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Insulin Antibodies ◽  
Insulin Insufficiency

The intravenous injection of anti-insulin serum produces an immediate increase in the blood glucose concentration of both normal and presumably "depancreatized" ducks. Whereas the blood glucose of the normal ducks returns to the preinjection concentration within 3.5 hr, the hyperglycemia of the depancreatized ducks persists for more than 5 hr. The response is attributed to an acute insulin insufficiency induced by insulin antibodies. Accordingly, insulin is as essential to the regulation of the blood glucose of the duck as it is to that of mammals. The data from depancreatized ducks suggest the presence of a remnant of splenic lobe of the pancreas or some extrapancreatic source of insulin.

The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus

2020 ◽  
Vol 30 (6) ◽  
Author(s):  
Arina D. Puspitasari ◽  
Hayu Kusuma ◽  
Dinda M.N. Ratri ◽  
Cahyo Wibisono ◽  
Budi Suprapti
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Postprandial Blood Glucose ◽  
Premixed Insulin ◽  
Acting Insulin ◽  
Blood Glucose Concentrations

AbstractBackgroundOne of the therapies used to treat type 2 diabetes mellitus (T2DM) disease is combination insulin which consists of rapid-acting insulin and intermediate-acting insulin (premixed). This study aimed to examine the profile of premixed insulin related to blood glucose concentration and to identify the drug interactions due to the combination of premixed insulin with other drugs taken by T2DM patients.MethodsThis study was a prospective observational study with cross-sectional data that were analyzed descriptively. The respondents invited were T2DM patients with or without complication or comorbid disease who received premixed insulin with or without a combination of oral antidiabetic therapy in the Outpatient Unit of Universitas Airlangga Hospital, Surabaya. The research instruments used are data sheet, patient medical record, and fasting and postprandial blood glucose concentration.ResultsA total of 118 patients received premixed insulin therapy, but only 80 patients were included in the inclusion criteria. Based on types of insulin, the combination of 30% aspart and 70% protamine aspart was used by 91.25% T2DM patients, and a combination of 25% insulin lispro and 75% protamine lispro was used by 8.75% T2DM patients. There were 30.3% of patients who could achieve the target of 80–130 mg/dL in fasting blood glucose concentrations, and 35.1% of patients achieved the target of ≤180 mg/dL in postprandial blood glucose concentration. Drug interactions may occur in patients who use premixed insulin with glimepiride, lisinopril, fenofibrate, candesartan, irbesartan, and gemfibrozil.ConclusionsIn this study, premixed insulin have not reached the target of fasting and postprandial blood glucose concentrations in most patients.

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