THE EFFECTS OF HORMONES ON THE CARBOHYDRATE METABOLISM OF THE LAMPREY LAMPETRA FLUVIATILIS

1965 ◽  
Vol 31 (2) ◽  
pp. 127-137 ◽  
Author(s):  
P. J. BENTLEY ◽  
B. K. FOLLETT
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Carbohydrate Metabolism ◽  
Glucose Concentration ◽  
Skeletal Muscles ◽  
Blood Glucose Concentration ◽  
Liver Glycogen ◽  
Arginine Vasotocin ◽  
Glycogen Concentration ◽  
Muscle Glycogen Concentration

SUMMARY River lampreys regulated their blood glucose concentration when injected with glucose. Mammalian insulin decreased the blood glucose concentration in the lamprey while adrenaline, cortisol and arginine vasotocin increased it. Glucagon had no effect initially but after a delay of 4 hr. decreased the blood glucose level. Insulin and cortisol increased the liver glycogen concentration. Adrenaline decreased the muscle glycogen concentration; vasotocin increased it. Treatment with alloxan increased the blood glucose concentration. Fat and glycogen in the lamprey are stored mainly in the skeletal muscles and their histochemical distribution in muscle is described. The results are discussed in relation to the metabolism of the migrating lamprey and the evolution of the control of carbohydrate metabolism in vertebrates.

THE CRITICALLY ILL CHILD: SALICYLATE INTOXICATION

PEDIATRICS ◽  
1969 ◽  
Vol 44 (3) ◽  
pp. 440-444
Author(s):  
William E. Segar
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Carbohydrate Metabolism ◽  
Glucose Level ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Co2 Concentration ◽  
Pharmacologic Agent ◽  
Peripheral Tissues ◽  
Salicylate Intoxication

Salicylate is a potent pharmacologic agent, and the rational therapy of salicylate intoxication must be based on an understanding of its pharmacologic actions and consequent pathophysiologic effects.l Because it acts to uncouple oxidative phosphorylation in a manner analogous to that of 2,4-dinitrophenol, salicylate is, first of all, a general metabolic stimulant.2 Oxygen consumption, carbon dioxide formation, and heat production are increased by its action; consequently, oxygen requirement, blood CO2 concentration, and the need to eliminate heat are also increased. Respiration, heart rate, and cardiac output must increase to satisfy the demands imposed by the acceleration of metabolic processes. Second, saiicylate interferes in a complex manner with the normal metabolism of carbohydrate.3 Many factors seem to be involved, some tending to decrease and others to increase the blood glucose concentralion, and, clinically, either hyperglycemia or hypoglycemia may be observed. Hyperglycemia may be partially explained by the release of epinephrmne due to activation of hypothalamic sympathetic centers. However, large doses of salicyiate also decrease aerobic metabolism and increase glucose-6-phosphatase activity, effects which tend to increase the blood glucose level. Hypoglycemia, on the other hand, may be caused by an increased utilization of glucose by peripheral tissues or by interference with gluconeogenesis by salicylates. Recent studies suggest that brain glucose concentration may be decreased despite minimal alterations in blood glucose level.4 As a result of these salicylate-mnduced alterations in carbohydrate metabolism, organic acids, particularly lactic, pyruvic, and acetoacetic, accumuiate.5 Infants appear to be particularly susceptible to the toxic effects of salicylate on carbohydrate metabolism and are more likely to have disturbances in blood glucose concentration and metabolic acidosis than are older children.

scholarly journals Blood glucose level in rats with different behavioral activity in the dynamics of repeated stress exposures

2019 ◽  
Vol 27 (1) ◽  
pp. 10-19
Author(s):  
Anastasiya Yu. Abramova ◽  
Elena V. Koplik ◽  
Irina V. Alekseyeva ◽  
Sergey S. Pertsov
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Stress Factors ◽  
Behavioral Activity ◽  
Glucose Content ◽  
Control Measurement ◽  
Repeated Stress

Aim. To study the effect of repeated stress on blood glucose level in rats with various behavioral characteristics and with different resistance to the development of adverse consequences of negative emotiogenic exposures. Materials and Methods. The animals were initially subjected to open field test to calculate the index of activity. Daily 4-h immobilization of rats in individual plastic cages for 8 days was used as a model of stress. Blood glucose concentration was measured with a glucometer (control measurement and on the 1st, 3rd and 8th days of repeated stress). Results. The basal level of glucose in behaviorally active (stress-resistant) rats was lower than in passive (stress-predisposed) specimens. Repeated exposure of rats to stress resulted in development of hyperglycemia. However, the dynamics of blood glucose concentration was different in specimens with different parameters of behavior. The increase in glucose concentration in active animals was most pronounced after a single exposure. By the 3rd and 8th days of stress exposures, glucose level in these rats progressively decreased (as compared to the 1st day), but remained above the basal level. Passive specimens were characterized by the increase in blood glucose concentration after a single and, particularly, after three-time restraint stress. Glucose content in these animals slightly decreased by the 8th day (as compared to the previous periods), but was above the basal level. Conclusion. The dynamics of abnormalities in carbohydrate metabolism (in particular, changes in blood glucose level) during chronic emotiogenic exposures differed in specimens with different resistance to stress factors. These data illustrate the importance of an indivi-dual approach to studying the pathophysiological mechanisms of progression and development of stress-induced disorders.

UNTERSUCHUNGEN ZUR GLUCONEOGENETISCHEN WIRKUNG VON CORTISOL

1969 ◽  
Vol 60 (1) ◽  
pp. 4-12 ◽  
Author(s):  
H. G. Meiers ◽  
W. Beien ◽  
T. Dieterich ◽  
W. Staib
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Liver Glycogen ◽  
Time Limit ◽  
Secondary Effects ◽  
Tryptophan Pyrrolase ◽  
Primary And Secondary Effects ◽  
Insulin Like Activity ◽  
Intact Rats

ABSTRACT The cortisol conditioned liver glycogen development was investigated within a time limit through the use of intact starved rats, which were made artificial diabetics with alloxan, and which were adrenalectomized. The liver glycogen and blood glucose concentration showed after one oral insertion of cortisol phased changes, which indicates endocrine counter-reactions. The insulin-like activity in plasma which was investigated through the use of intact rats showed an increase, while the cortisol conditioned induction of the liver – tryptophan-pyrrolase from endocrine regulations was not influenced, the cortisol conditioned liver glycogen development represented itself as a combined reaction of primary and secondary effects. An insular reaction obviously follows a primary gluconeogenetic one. Then an adrenalic counter-regulation results. These factors ascertain the degree and duration of the liver glycogen sedimentation.

EFFECT OF SYNTHETIC HUMAN 1,39-CORTICOTROPHIN ON BLOOD GLUCOSE LEVEL IN MICE

1970 ◽  
Vol 65 (3) ◽  
pp. 481-489
Author(s):  
F. A. László ◽  
I. Szijj ◽  
F. Durszt ◽  
K. Kovács
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Insulin Release ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
The Other ◽  
Glucose Content ◽  
High Blood Glucose ◽  
Adrenocortical Activity ◽  
Initial Blood

ABSTRACT The hypoglycaemic action of synthetic human 1,39-corticotrophin was determined in mice and its effectiveness compared with highly purified porcine corticotrophin. Synthetic human 1,39-corticotrophin (0.01 mg = 1.0 IU) and porcine corticotrophin (1.0 IU) induced a transient hypoglycaemia. After the administration of the porcine corticotrophin the decrease in the blood glucose concentration was somewhat more marked and prolonged. Adrenocortical activity was not necessary for the development of hypoglycaemia. In adrenalectomized mice, dexamethasone substitution by increasing the initial blood glucose content, made the effect more pronounced. Pretreatment with corticotrophin reduced the extent of the alloxan-induced transitory hyperglycaemia. On the other hand, it did not influence the high blood glucose values in manifest alloxan diabetic animals. It is possible that corticotrophin induces hypoglycaemia through insulin release. This is an extra-adrenal effect of corticotrophin as it is also observed in adrenalectomized mice.

scholarly journals Study of the hyperglycemic condition in diseases of liver in obese clinical patients

2018 ◽  
Vol 8 (6-s) ◽  
pp. 204-208
Author(s):  
Chander Jeet Singh ◽  
Dinesh Kumar
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Experimental Studies ◽  
Glucose Levels ◽  
Sensory Evoked Potentials ◽  
Sensory Evoked ◽  
Blood Glucose Concentrations

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, the threshold for symptoms of hyperglycemia is on average a blood glucose level of 3.0 mmol/l Mitrakou reported autonomic symptoms of hyperglycemia to begin at a blood glucose level of 3.2 mmol/l, and deterioration in cognitive function tests at a level of 2.7 mmo/l. When sensory evoked potentials were measured in relation to blood glucose concentrations in infants and children with episodes of hyperglycemia, abnormalities were noted at blood glucose levels less than 2.6 mmol/l. Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis. 

scholarly journals The Effect of Aerobic Exercises on Blood Glucose Concentration in Healthy Girls and Girls with Type 1 Diabetes Mellitus

2018 ◽  
Vol 4 (63) ◽  
Author(s):  
Sandrija Sideravičiūtė ◽  
Alina Gailiūnienė ◽  
Kristina Visagurskienė ◽  
Daiva Vizbaraitė
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Swimming Training

Regular aerobic exercises are benefi cial not only for healthy people. Physical activity plays a big part in the lives of children and adolescents with type 1 diabetes mellitus too. Walking, biking, swimming, dancing, and many other activities are considered to be aerobic exercises and they are all healthy. What kind of physical exercises are the most useful for the youth with type 1 diabetes mellitus? So, the aim of the present study was to estimate and compare the effect of aerobic exercise such as swimming and aerobics, on blood glucose concentration of young girls. 19 girls aged 16.5 ± 0.24 years with the duration of diabetes for 8.1 ± 0.9 years and 28 healthy girls aged 16.9 ± 0.36 years participated in the study. Two experiments were carried out. The fi rst experiment was a 7-day physical exercise program, consisting of aerobics and swimming training sessions each day. The other experiment was a 14-week swimming program, where all the participants attended swimming training sessions two times per week, and there were all in all 28 training sessions. Glycemia control was assessed by blood glucose level (mmol / l) monitored before and after every training sessions during the 7-day and 14-week physical programs. After the analysis of blood test it was found, that the 7-day physical program decreased blood glucose concentration for all subjects (p < 0.05) but, swimming had a greater effect on blood glucose control for girls with type 1 diabetes mellitus than aerobics (p < 0.01). After the 14-week duration swimming program, hyperglycemia signifi cantly decre-ased for all subjects too, but it’s response to the regular physical activity in the water was the highest for diabetics (p < 0.001).The evidence obtained in this study showed that both swimming and aerobics decreased blood glucose concentration for healthy subject and for subjects with diabetes. But swimming had a greater effect on the dynamics of blood glucose level for girls with type 1 diabetes mellitus than aerobics.Keywords: type 1 diabetes mellitus, swimming, aerobics, blood glucose, glycemia.

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