Hyperglycemic nonketotic coma in insulin-dependent diabetes mellitus. Report of a patient with previous history of diabetic ketoacidosis and pituitary stalk section

JAMA ◽  
1968 ◽  
Vol 203 (7) ◽  
pp. 461-463 ◽  
Author(s):  
H. D. Kolodny
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Previous History ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Pituitary Stalk ◽  
Dependent Diabetes Mellitus ◽  
History Of ◽  
Insulin Dependent

scholarly journals Myocardial dysfunction associated with diabetic ketoacidosis in a 5-year-old girl

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984779 ◽  
Author(s):  
Amjad Halloum ◽  
Shaikha Al Neyadi
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Brain Edema ◽  
Myocardial Dysfunction ◽  
Insulin Dependent Diabetes Mellitus ◽  
Inotropic Support ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
New Onset

In this study, we report a case of a 5-year-old girl with new onset of insulin-dependent diabetes mellitus, who presented with severe diabetic ketoacidosis associated with brain edema and severe myocardial dysfunction, needing intubation and inotropic support. To our knowledge, this is the youngest reported case with severe diabetic ketoacidosis complicated with myocardial dysfunction.

Natural history of gallstones in non-insulin-dependent diabetes mellitus

1994 ◽  
Vol 39 (8) ◽  
pp. 1704-1707 ◽  
Author(s):  
Giuseppe Del Favero ◽  
Alessandro Caroli ◽  
Tamara Meggiato ◽  
Antonio Volpi ◽  
Paola Scalon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Natural History ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
History Of ◽  
Insulin Dependent

Diabetic ketoacidosis as a hallmark of autoimmune diabetes occurring after two cycles of cemiplimab

2021 ◽  
pp. 107815522110605
Author(s):  
Nasrin Saleh Jouneghani ◽  
John Phillip ◽  
Constantin A Dasanu
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Ketoacidosis ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Insulin Dependent Diabetes Mellitus ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

Introduction Clinical indications of immune checkpoint inhibitors have expanded to a variety of malignancies. Nearly 50% of patients with advanced cutaneous squamous cell carcinoma, respond to the programmed-death 1 inhibitor cemiplimab. To date, insulin-dependent diabetes mellitus has been documented with the use of several immune checkpoint inhibitors but not cemiplimab. Case report We report herein the first case of a patient with cutaneous squamous cell carcinoma who developed diabetic ketoacidosis and insulin-dependent diabetes mellitus following only two cycles of cemiplimab. A score of 6 on the Naranjo nomogram makes the causality relationship between cemiplimab use and the insulin-dependent diabetes mellitus probable. Management and outcome The patient's developed diabetic ketoacidosis was managed with intravenous fluids and intravenous insulin, with a prompt resolution. Cemiplimab was discontinued, and the patient was discharged on long-acting and short-acting insulin therapy, with a follow-up with endocrinology. Discussion/conclusions The mechanism by which cemiplimab caused insulin-dependent diabetes mellitus is most likely due to lack of endogenous insulin production in the setting of immune-mediated loss of pancreatic beta-cells. Patients may benefit from fasting blood glucose monitoring and early immune checkpoint inhibitor discontinuation where elevated serum glucose is detected.

Insulinoma in a Dog With Pre-existing Insulin-Dependent Diabetes Mellitus

2007 ◽  
Vol 43 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Elizabeth R. Bryson ◽  
Elisabeth C.R. Snead ◽  
Chantal McMillan ◽  
Lori MacDougall ◽  
Andrew L. Allen
Keyword(s):  
Diabetes Mellitus ◽  
Lymph Node ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Golden Retriever ◽  
Presumptive Diagnosis ◽  
Mesenteric Lymph ◽  
History Of ◽  
Insulin Dependent

A 10-year-old golden retriever with a 3-year history of insulin-dependent diabetes mellitus was presented with recurring episodes of hypoglycemia and seizures. A presumptive diagnosis of an insulinoma was made based on hypoglycemia with concurrent endogenous hyperinsulinemia and unremarkable radiographic and ultrasonographic images of the chest and abdomen. A beta cell carcinoma of the pancreas with metastasis to the liver and a mesenteric lymph node was confirmed by surgery and histopathology.

Increased circulating leptin concentrations in insulin-resistant first-degree relatives of patients with non-insulin-dependent diabetes mellitus: relationship to body composition and insulin sensitivity but not to family history of non-insulin-dependent diabetes mellitus

1997 ◽  
Vol 136 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Birgit Nyholm ◽  
Sanne Fisker ◽  
Sten Lund ◽  
Niels Møller ◽  
Ole Schmitz
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Family History ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Serum Leptin ◽  
Percentage Body Fat ◽  
History Of ◽  
Insulin Dependent

Abstract Objective: To explore a possible association between serum concentration of leptin, insulin sensitivity and non-insulin-dependent diabetes mellitus (NIDDM). Design: Forty first-degree relatives of NIDDM patients and 35 control subjects matched for age, gender and body mass index underwent a hyperinsulinaemic (insulin infusion rate 0·6 mU/kg per min) euglycaemic clamp combined with indirect calorimetry. Serum leptin was measured in fasting blood samples obtained before the clamp. Results: All subjects had a normal oral glucose tolerance test. Insulin-stimulated glucose uptake (M) was decreased in the relatives compared with the control subjects (4·58 ± 0·27 versus 606 ± 0·25 mg/kg per min, P < 0·001). Conversely, serum leptin was increased in the relatives (9·6·/÷ 1·1 versus 6·1·/÷ 1·2 ng/ml (geometric mean·/÷ antilog s.e.m.). P < 0·05). A positive correlation was observed between circulating levels of leptin and percentage body fat (P < 0·001) and inverse correlations were found between leptin, M (P < 0·01), maximal aerobic capacity (VO2 max) (P < 0·01), and energy expenditure (P ≤ 0·01) in both groups. In multiple linear regression analysis, percentage body fat, gender and M significantly determined the level of leptin (r2 = 0·71, P < 0·001) whereas family history of NIDDM and VO2 max did not. Conclusion: Serum leptin is increased in insulin-resistant offspring of NIDDM patients. The association between leptin, anthropometric measures and insulin sensitivity is, however, comparable with that of a control group. The increased concentrations of serum leptin in the relatives appear to be associated with the insulin resistance, but not with a family history of NIDDM. European Journal of Endocrinology 136 173–179

Sign in / Sign up

Export Citation Format

Share Document