Systolic hypertension in the elderly. Hemodynamic response to long-term thiazide diuretic therapy and its side effects

JAMA ◽  
1983 ◽  
Vol 250 (20) ◽  
pp. 2807-2813 ◽  
Author(s):  
S. Vardan
Keyword(s):  
Side Effects ◽  
Thiazide Diuretic ◽  
Systolic Hypertension ◽  
Diuretic Therapy ◽  
The Elderly ◽  
Hemodynamic Response

Arterial hypertension + past stroke – a case report

2021 ◽  
Vol 14 (3) ◽  
pp. 324-326
Author(s):  
Maria Łukasiewicz ◽  
Marta Swarowska-Skuza
Keyword(s):  
Blood Pressure ◽  
Case Report ◽  
Chronic Disease ◽  
Side Effects ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Systolic Hypertension ◽  
The Elderly ◽  
Isolated Systolic Hypertension ◽  
Special Group

Arterial hypertension, as a very widespread chronic disease, and thus differing in both pathomechanism and course in patients, requires a significant individualization of pharmacotherapy. One such special group is the elderly. Both the low-renin pathomechanism of arterial hypertension and its phenotype (isolated systolic hypertension) imply the choice of a specific pharmacotherapy. Additionally, in this group, side effects should be observed much more vigilantly, while target blood pressure values should be treated more liberally. An example of antihypertensive therapy in a patient belonging to the group described is presented in the following case.

scholarly journals Dual orexin receptor antagonist in treatment of insomnia

Engrami ◽  
2020 ◽  
Vol 42 (2) ◽  
pp. 57-68
Author(s):  
Nikola Trajanović
Keyword(s):  
Circadian Rhythm ◽  
Side Effects ◽  
Receptor Antagonist ◽  
Safety Profile ◽  
The Elderly ◽  
First Line ◽  
Future Studies ◽  
Good Safety Profile ◽  
Circadian Rhythm Disorders

A novel group of medications, dual orexin receptor antagonists, emerged as a competent group that challenges current first-line hypnotics. They have relatively infrequent and mostly well-tolerated side effects, primarily in the form of residual somnolence, fatigue and nightmares/disturbing dreams. The advantage over conventional hypnotics stems from the specifics of their target receptors, which translates into lack of tolerance after long term use and good safety profile. They are particularly favoured in some specific populations, including the elderly. Ongoing and future studies are set to explore their effect on selected conditions, such as addiction and psychiatric disorders, dementias, perimenopausal condition and circadian rhythm disorders, to name a few.

Hemodynamic response to orthostatic stress in the elderly with systolic systemic hypertension before and after long-term thiazide therapy

1993 ◽  
Vol 71 (7) ◽  
pp. 582-586 ◽  
Author(s):  
Suman Vardan ◽  
Norma E. Hill ◽  
Kishan G. Mehrotra ◽  
Saktipada Mookherjee ◽  
Harold Smulyan
Keyword(s):  
The Elderly ◽  
Hemodynamic Response ◽  
Systemic Hypertension ◽  
Orthostatic Stress ◽  
Before And After

THE EFFECTS OF DISCONTINUING LONG-TERM DIURETIC THERAPY IN THE ELDERLY

1977 ◽  
Vol 6 (1) ◽  
pp. 38-45 ◽  
Author(s):  
M. L. BURR ◽  
S. KING ◽  
H. E. F. DAVIES ◽  
M. S. PATHY
Keyword(s):  
Diuretic Therapy ◽  
The Elderly

Efficacy and acceptability of tianeptine in the elderly: a review of clinical trials

1993 ◽  
Vol 8 (S2) ◽  
pp. 117s-124s
Author(s):  
F Raffaitin
Keyword(s):  
Side Effects ◽  
The Elderly ◽  
Elderly Subjects ◽  
High Risk Population ◽  
Refractory Depression ◽  
Long Term Effect ◽  
Pre Treatment ◽  
Low Incidence ◽  
Drop Outs

SummaryThe acceptability and efficacy of tianeptine were evaluated in three open trials in a total of 549 elderly patients, 426 of whom were treated for 3 months and 188 for 1 year. The therapeutic effect was that expected from an effective antidepressant, with a marked response after treatment for one month. In the geriatric trial, where patients were primarily dysthymic, continuation of treatment after 6 months consolidated the improvement already observed. Tianeptine also had a favorable long-term effect in chronic refractory depression. Drop-outs due to side-effects were few (4.4%), despite the high risk population. All pre-treatment complaints improved on tianeptine. The high frequency of somatic complaints expressed before treatment confirmed the extent to which depression is somatised in the elderly. Concomitant physical disease present in 87% of patients did not restrict the use of tianeptine. The fact that tianeptine has a low incidence of anticholinergic effects and no affinity for either H1 or α1 receptors makes it a particularly easy drug to use in elderly subjects who are sensitive to the side-effects of psychotropic agents.

LONG-TERM ANABOLIC THERAPY IN THE ELDERLY

1977 ◽  
Vol 6 (4) ◽  
pp. 221-227 ◽  
Author(s):  
M. D. W. LYE ◽  
A. E. S. RITCH
Keyword(s):  
Side Effects ◽  
The Elderly ◽  
Fat Free Mass ◽  
Activity Levels ◽  
Double Blind Trial ◽  
Long Term Effects ◽  
Double Blind ◽  
Anabolic Agent ◽  
Anabolic Therapy

Abstract The anabolic agent stanozolol has been used to increase weight and activity in the elderly, but its long-term effects are largely unknown. A double-blind trial of stanozolol against placebo was continued for 12 months. Measurements of weight, fat, fat-free mass, behviour and activity were made at regular intervala, plus detailed biochemical and hermatological profiles. There were no differences between the two groups in respect of weight, fat, fat-free mass and activity levels. There were significant increase in hemoglobin at six and 12 months and packed cell volume at 12 months in the active group. No androgenic side-effects were encountered.

Sign in / Sign up

Export Citation Format

Share Document