Association of Leisure-Time Physical Activity Across the Adult Life Course With All-Cause and Cause-Specific Mortality

Abstract Background We aimed to test which life course model best described the association between leisure-time physical activity (LTPA) and multimorbidity at age 55. We analyzed data from birth to age 55 using the database from the 1958 National Child Development Survey. Methods Multimorbidity was considered as the presence of more than one chronic condition. LTPA was measured through questionnaires from 1965 (age 7) to 2013 (age 55), which were applied in eight different occasions. We compared the fit of a series of nested adjusted logistic regression models (representing either the critical, accumulation or sensitive period models) with a fully saturated model. Data were reported as odds ratio (OR) and 95% confidence interval (CI). Results From an eligible sample of 15,613 cohort members, 9137 were interviewed in the latest sweep (58.5%). Men were more physically active than women at ages 11, 16, and 23 (p < 0.001). LTPA every day in the week was more frequent in women than men in ages 33, 42, and 50 (p < 0.001). The prevalence of multimorbidity at age 55 was 33.0% (n = 2778). The sensitive analysis revealed that LTPA during adolescence (OR: 0.83; 95% CI: 0.70, 0.98) and mid adult life (age 50 and 55; OR: 0.82; 95%CI: 0.69, 0.98) have a stronger effect on the risk for multimorbidity at age 55 considering all other life stages in the model. Also, adolescence showed a critical independent effect on the risk for multimorbidity (OR: 0.82; 95%CI: 0.70, 0.97). No difference was found between those models. Conclusions These data support the notion of a protective physical activity “legacy” at early ages of childhood against multimorbidity at older ages. We highlight the need for LTPA promotion through intervention tailored especially on schooling and older ages in order to reduce the burden of multimorbidity.

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Multimorbidity and Leisure-Time Physical Activity Over The Life Course: A Population-Based Birth Cohort Study.

10.21203/rs.3.rs-86171/v1 ◽

2020 ◽

Author(s):

Natan Feter ◽

Jayne S Leite ◽

Daniel Umpierre ◽

Eduardo L Caputo ◽

Airton J Rombaldi

Keyword(s):

Physical Activity ◽

Life Course ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Adult Life ◽

Population Based ◽

Independent Effect ◽

Sensitive Period ◽

Birth Cohort Study ◽

Saturated Model

Abstract Background: We aimed to test which life course model best described the association between leisure-time physical activity (LTPA) and multimorbidity at age 55. We analyzed data from birth to age 55 using the database from the 1958 National Child Development Survey. Methods: Multimorbidity was considered as the presence of more than one chronic condition. LTPA was measured through questionnaires from 1965 (age 7) to 2013 (age 55), which were applied in eight different occasions. We compared the fit of a series of nested adjusted logistic regression models (representing either the critical, accumulation or sensitive period models) with a fully saturated model. Data were reported as odds ratio (OR) and 95% confidence interval (CI).Results: From the initial sample of 17,415 cohort members, 9,134 were interviewed in the latest sweep (49.2%). Men were more physically active than women at ages 11, 16, and 23 (p<0.001). LTPA every day in the week was more frequent in women than men in ages 33, 42, and 50 (p<0.001). The sensitive analysis revealed that LTPA during adolescence (OR: 0.72; 95% CI: 0.57, 0.92) and late adult life (OR: 0.71; 95%CI: 0.55, 0.91) have a stronger effect on the risk for multimorbidity at age 55 considering all other life stages in the model. Also, adolescence showed a critical independent effect on the risk for multimorbidity (OR: 0.74; 95%CI: 0.59, 0.92). No difference was found between those models. Conclusions: These data support the notion of a protective physical activity “legacy” at early ages of childhood against multimorbidity at older ages. We highlight the need for LTPA promotion through intervention tailored especially on schooling and older ages in order to reduce the burden of multimorbidity.

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Walking Pace, Leisure Time Physical Activity, and Resting Heart Rate in Relation to Disease-Specific Mortality in London: 40 Years Follow-Up of the Original Whitehall Study. An Update of Our Work with Professor Jerry N. Morris (1910–2009)

Annals of Epidemiology ◽

10.1016/j.annepidem.2010.03.014 ◽

2010 ◽

Vol 20 (9) ◽

pp. 661-669 ◽

Cited By ~ 30

Author(s):

G. David Batty ◽

Martin J. Shipley ◽

Mika Kivimaki ◽

Michael Marmot ◽

George Davey Smith

Keyword(s):

Physical Activity ◽

Heart Rate ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Resting Heart Rate ◽

Specific Mortality ◽

Disease Specific Mortality ◽

Disease Specific

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Prenatal and childhood growth and leisure time physical activity in adult life

European Journal of Public Health ◽

10.1093/eurpub/ckq176 ◽

2010 ◽

Vol 21 (6) ◽

pp. 719-724 ◽

Cited By ~ 11

Author(s):

M. K. Salonen ◽

E. Kajantie ◽

C. Osmond ◽

T. Forsen ◽

H. Yliharsila ◽

...

Keyword(s):

Physical Activity ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Adult Life ◽

Childhood Growth

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Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors—Results from multiple Swedish studies

PLoS ONE ◽

10.1371/journal.pone.0256476 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0256476

Author(s):

Lars Lind ◽

Björn Zethelius ◽

Eva Lindberg ◽

Nancy L. Pedersen ◽

Liisa Byberg

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Cardiovascular Risk ◽

Life Span ◽

Cardiovascular Risk Factors ◽

Longitudinal Studies ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Adult Life ◽

Adult Life Span

Objective To evaluate how self-reported leisure-time physical activity (PA) changes during the adult life span, and to study how PA is related to cardiovascular risk factors using longitudinal studies. Methods Several Swedish population-based longitudinal studies were used in the present study (PIVUS, ULSAM, SHE, and SHM, ranging from hundreds to 30,000 participants) to represent information across the adult life span in both sexes. Also, two cross-sectional studies were used as comparison (EpiHealth, LifeGene). PA was assessed by questionnaires on a four or five-level scale. Results Taking results from several samples into account, an increase in PA from middle-age up to 70 years was found in males, but not in females. Following age 70, a decline in PA was seen. Young adults reported both a higher proportion of sedentary behavior and a higher proportion high PA than the elderly. Females generally reported a lower PA at all ages. PA was mainly associated with serum triglycerides and HDL-cholesterol, but also weaker relationships with fasting glucose, blood pressure and BMI were found. These relationships were generally less strong in elderly subjects. Conclusion Using data from multiple longitudinal samples the development of PA over the adult life span could be described in detail and the relationships between PA and cardiovascular risk factors were portrayed. In general, a higher or increased physical activity over time was associated with a more beneficial cardiovascular risk factor profile, especially lipid levels.

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Economic stress and low leisure-time physical activity: Two life course hypotheses

SSM - Population Health ◽

10.1016/j.ssmph.2018.04.005 ◽

2018 ◽

Vol 4 ◽

pp. 358-364 ◽

Cited By ~ 5

Author(s):

Martin Lindström ◽

Maria Rosvall

Keyword(s):

Physical Activity ◽

Life Course ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Economic Stress

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Taking Up and Terminating Leisure-Time Physical Activity over the Life Course: The Role of Life Events in the Familial and Occupational Life Domains

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18189809 ◽

2021 ◽

Vol 18 (18) ◽

pp. 9809

Author(s):

Lars Lenze ◽

Claudia Klostermann ◽

Markus Lamprecht ◽

Siegfried Nagel

Keyword(s):

Physical Activity ◽

Life Course ◽

Life Events ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Life Domains ◽

Becoming A Mother ◽

The Life Course ◽

The Relationship ◽

Occupational Life

Leisure-time physical activity (LTPA) is associated with various health-promoting effects. However, little is known about the relationship between life events and changes in LTPA over the life course, especially when multiple life events occur simultaneously. Therefore, this study examines taking up and terminating LTPA associated with life events in the familial and occupational life domains over 16 years of 16–76-year-old Swiss inhabitants (n = 1857) in a retrospective longitudinal cohort design, using a validated telephone survey and multilevel discrete-time event-history analyses. The results show that taking up LTPA was more likely when ending a relationship and retiring and less likely when becoming a parent; terminating LTPA was more likely when ending a job, starting vocational training after 30 years, a relationship ended for men, and becoming a mother with increasing age. If experiencing multiple life events simultaneously, the greater the number of life events, the more likely persons aged 45–70 years were to take up LTPA and, conversely, the more likely persons aged 15–44 years to terminate LTPA. The relationship between life events and changes in LTPA over the life course was often age dependent, especially when experiencing multiple life events simultaneously. The findings should be considered when promoting LTPA.

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Health-Related Findings Among Twin Pairs Discordant for Leisure-Time Physical Activity for 32 Years: The TWINACTIVE Study Synopsis

Twin Research and Human Genetics ◽

10.1017/thg.2015.23 ◽

2015 ◽

Vol 18 (3) ◽

pp. 266-272 ◽

Cited By ~ 11

Author(s):

Tuija Leskinen ◽

Urho M. Kujala

Keyword(s):

Physical Activity ◽

Leisure Time ◽

Leisure Time Physical Activity ◽

Adult Life ◽

Related Factors ◽

Time Activity ◽

Regulatory Pathways ◽

Fat Depots ◽

Health Related

We are lacking very long-term and controlled intervention studies investigating the effects of habitual physical activity on health-related factors. To address this gap, we performed a natural experiment by identifying same-sex twin pairs in which the co-twins of each pair differed with respect to leisure-time physical-activity habits throughout their adult life. Our criterion for the discordance was that the same co-twin had a higher leisure time-activity volume than that of the other member of the pair at the majority –– if not all –– of the follow-up time points according to reported/interviewed physical-activity data. Overall, we identified and conducted multidimensional health-related measurements (including fitness, body composition, cardiometabolic risk factor levels, bone and arterial status, and exercise motivation) of 16 twin pairs (seven monozygotic (MZ) and nine dizygotic (DZ) pairs, mean age 60 years) who had persistent discordance in leisure-time physical-activity habits over three decades (TWINACTIVE study). In our discordant-pair study design, after adjusting for sequence-level genes, both systemic-level metabolic, and site-specific structural findings differed significantly in the pairwise analysis in MZ pairs only. These findings included intrapair differences in accumulated fat depots and structure of heart, arteries, and bones. In addition, our study revealed intrapair differences in metabolic and regulatory pathways, which may partly explain the mechanistic links between long-term physical activity, phenotypic changes, and decreased risk of cardiometabolic diseases.

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