scholarly journals In the spotlight: Julio Celis, the Founding Editor of Molecular Oncology

2022 ◽  
Vol 16 (1) ◽  
pp. 3-7
Author(s):  
Kevin M. Ryan
2008 ◽  
Vol 21 (1) ◽  
pp. 85-89
Author(s):  
Jarosław Sawiniec ◽  
Krzysztof Borkowski ◽  
Piotr Paluszkiewicz

2020 ◽  
Vol 20 (21) ◽  
pp. 1868-1875
Author(s):  
Ghazala Butt ◽  
Ammad A. Farooqi ◽  
Aima Adylova ◽  
Rukset Attar ◽  
Seher Yilmaz ◽  
...  

Treatment options for effective treatment of cancer with minimum off-target effects and maximum clinical outcomes have remained overarching goals in the clinical oncology. Vitamin C has remained in the shadows of controversy since the past few decades; burgeoning evidence has started to shed light on wide-ranging anticancer effects exerted by Vitamin C to induce apoptosis in drug-resistant cancer cells, inhibit uncontrolled proliferation of the cancer cells and metastatic spread. Landmark achievements in molecular oncology have ushered in a new era, and researchers have focused on the identification of oncogenic pathways regulated by Vitamin C in different cancers. However, there are visible knowledge gaps in our understanding related to the ability of Vitamin C to modulate a myriad of transduction cascades. There are scattered pieces of scientific evidence about promising potential of Vitamin C to regulate JAK-STAT, TGF/SMAD, TRAIL and microRNAs in different cancers. However, published data is insufficient and needs to be investigated comprehensively to enable basic and clinical researchers to reap full benefits and promote result-oriented transition of Vitamin C into various phases of clinical trials. In this review, we will emphasize on available evidence related to the regulation of oncogenic cell signaling pathways by Vitamin C in different cancers. We will also highlight the conceptual gaps, which need detailed and cutting-edge research.


2021 ◽  
Vol 22 (9) ◽  
pp. 4732
Author(s):  
Vincenza Ylenia Cusenza ◽  
Alessandra Bisagni ◽  
Monia Rinaldini ◽  
Chiara Cattani ◽  
Raffaele Frazzi

The cytogenetic and molecular assessment of deletions, amplifications and rearrangements are key aspects in the diagnosis and therapy of cancer. Not only the initial evaluation and classification of the disease, but also the follow-up of the tumor rely on these laboratory approaches. The therapeutic choice can be guided by the results of the laboratory testing. Genetic deletions and/or amplifications directly affect the susceptibility or the resistance to specific therapies. In an era of personalized medicine, the correct and reliable molecular characterization of the disease, also during the therapeutic path, acquires a pivotal role. Molecular assays like multiplex ligation-dependent probe amplification and droplet digital PCR represent exceptional tools for a sensitive and reliable detection of genetic alterations and deserve a role in molecular oncology. In this manuscript we provide a technical comparison of these two approaches with the golden standard represented by fluorescence in situ hybridization. We also describe some relevant targets currently evaluated with these techniques in solid and hematologic tumors.


2000 ◽  
Vol 421 ◽  
pp. 1-14 ◽  
Author(s):  
HERBERT E. HUPPERT

George Batchelor was one of the giants of fluid mechanics in the second half of the twentieth century. He had a passion for physical and quantitative understanding of fluid flows and a single-minded determination that fluid mechanics should be pursued as a subject in its own right. He once wrote that he ‘spent a lifetime happily within its boundaries’. Six feet tall, thin and youthful in appearance, George's unchanging attire and demeanour contrasted with his ever-evolving scientific insights and contributions. His strongly held and carefully articulated opinions, coupled with his forthright objectivity, shone through everything he undertook.George's pervasive influence sprang from a number of factors. First, he conducted imaginative, ground-breaking research, which was always based on clear physical thinking. Second, he founded a school of fluid mechanics, inspired by his mentor G. I. Taylor, that became part of the world renowned Department of Applied Mathematics and Theoretical Physics (DAMTP) of which he was the Head from its inception in 1959 until he retired from his Professorship in 1983. Third, he established this Journal in 1956 and actively oversaw all its activities for more than forty years, until he relinquished his editorship at the end of 1998. Fourth, he wrote the monumental textbook An Introduction to Fluid Dynamics, which first appeared in 1967, has been translated into four languages and has been relaunched this year, the year of his death. This book, which describes the fundamentals of the subject and discusses many applications, has been closely studied and frequently cited by generations of students and research workers. It has already sold over 45 000 copies. And fifth, but not finally, he helped initiate a number of international organizations (often European), such as the European Mechanics Committee (now Society) and the biennial Polish Fluid Mechanics Meetings, and contributed extensively to the running of IUTAM, the International Union of Theoretical and Applied Mechanics. The aim of all of these associations is to foster fluid (and to some extent solid) mechanics and to encourage the development of the subject.


1995 ◽  
Vol 112 (5) ◽  
pp. P88-P89
Author(s):  
Norris K. Lee

Educational objectives: To understand basic molecular biological concepts and breakthroughs as they apply to the head and neck cancer model and to envision the future of head and neck cancer treatment, within the context of molecular biology.


MedEdPublish ◽  
2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Ariela Borgmann ◽  
Gabriella Giandotti Gomar ◽  
Nicole Borini ◽  
Rogério Saad Vaz

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