Role of Chemical Biology in Understanding and Treating Disease

2012 ◽  
Author(s):  
David Selwood
Keyword(s):  
Chemical Biology

scholarly journals Using chemical biology to assess and modulate mitochondria: progress and challenges

2017 ◽  
Vol 7 (2) ◽  
pp. 20160151 ◽  
Author(s):  
Angela Logan ◽  
Michael P. Murphy
Keyword(s):  
Mitochondrial Function ◽  
Chemical Biology ◽  
Biomedical Sciences ◽  
Interdisciplinary Approaches ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Future Challenges ◽  
The Many ◽  
Opening Up

Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field.

scholarly journals Joining the journey to near infrared (NIR) imaging: the emerging role of lanthanides in the designing of molecular probes

2020 ◽  
Vol 7 (2) ◽  
pp. 289-299 ◽  
Author(s):  
Guo-Qing Jin ◽  
Yingying Ning ◽  
Jing-Xing Geng ◽  
Zhi-Fan Jiang ◽  
Yan Wang ◽  
...  
Keyword(s):  
Chemical Biology ◽  
Near Infrared ◽  
Coordination Complexes ◽  
Molecular Probes ◽  
Nir Imaging ◽  
Recent Developments

The recent developments and prospects of near-infrared molecular probes based on luminescent lanthanide coordination complexes in bioimaging are described, which is important to emphasise the importance of lanthanide chemical biology.

scholarly journals Bioinformatics challenges and perspectives when studying the effect of epigenetic modifications on alternative splicing

2018 ◽  
Vol 373 (1748) ◽  
pp. 20170073 ◽  
Author(s):  
Clare Pacini ◽  
Magdalena J. Koziol
Keyword(s):  
Alternative Splicing ◽  
Chemical Biology ◽  
Epigenetic Modifications ◽  
Mrna Splicing ◽  
Epigenetic Changes ◽  
Epigenetic Marks

It is widely known that epigenetic modifications are important in regulating transcription, but several have also been reported in alternative splicing. The regulation of pre-mRNA splicing is important to explain proteomic diversity and the misregulation of splicing has been implicated in many diseases. Here, we give a brief overview of the role of epigenetics in alternative splicing and disease. We then discuss the bioinformatics methods that can be used to model interactions between epigenetic marks and regulators of splicing. These models can be used to identify alternative splicing and epigenetic changes across different phenotypes. This article is part of a discussion meeting issue ‘Frontiers in epigenetic chemical biology’.

Role of Chemical Biology in Tuberculosis Drug Discovery and Diagnosis

2018 ◽  
Vol 4 (4) ◽  
pp. 458-466 ◽  
Author(s):  
Katharina Kolbe ◽  
Sri Kumar Veleti ◽  
Emma E. Johnson ◽  
Young-Woo Cho ◽  
Sangmi Oh ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Chemical Biology

Double-edged sword in cells: chemical biology studies of the vital role of cytochrome c in the intrinsic pre-apoptotic mitochondria leakage pathway

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28258-28269 ◽  
Author(s):  
Zhi-Peng Wang ◽  
Xiao-Zhe Ding ◽  
Jun Wang ◽  
Yi-Ming Li
Keyword(s):  
Cell Death ◽  
Electron Transport ◽  
Cytochrome C ◽  
Electron Transport Chain ◽  
Chemical Biology ◽  
Vital Role ◽  
Mitochondrial Electron Transport Chain ◽  
Transport Chain ◽  
Cyt C

Besides functioning as an electron transporter in the mitochondrial electron transport chain, cytochrome c (cyt c) is also one of the determinants in the execution of cell death.

scholarly journals The Role of Chemical Biology in the Discovery and Understanding of Ferroptosis

2020 ◽  
Vol 27 (4) ◽  
pp. 363-364
Author(s):  
Mishtu Dey ◽  
Bridget Wagner
Keyword(s):  
Chemical Biology

Editorial: The Role of Selenium in Chemical Biology

2008 ◽  
Vol 5 (3) ◽  
pp. 357-358 ◽  
Author(s):  
Janos Rétey
Keyword(s):  
Chemical Biology
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