Inhibition of Thyrotrophic Activity with Acetylated Thyrotrophic Hormone Preparations

2008 ◽  
pp. 38-51
Author(s):  
Martin Sonenberg ◽  
William L. Money
Keyword(s):  
Thyrotrophic Hormone

INHIBITION OF THYROGLOBULIN BIOSYNTHESIS AND DEGRADATION BY EXCESS IODIDE. SYNERGISM WITH LITHIUM

1976 ◽  
Vol 81 (2) ◽  
pp. 495-506 ◽  
Author(s):  
A. Radvila ◽  
R. Roost ◽  
H. Bürgi ◽  
H. Kohler ◽  
H. Studer
Keyword(s):  
Protein Synthesis ◽  
Thyroid Gland ◽  
Inhibitory Action ◽  
Inhibit Protein Synthesis ◽  
Thyrotrophic Hormone ◽  
Thyroid Glands ◽  
Pre Treatment ◽  
Excess Iodide ◽  
Kidney Liver

ABSTRACT Lithium and excess iodide inhibit the release of thyroid hormone from preformed stores. We thus tested the hypothesis that this was due to an inhibition of thyroglobulin breakdown. Rats were pre-treated with propylthiouracil (PTU) for 3 weeks in order to deplete their thyroids of thyroglobulin. While the PTU was continued, lithium chloride (0.25 mEq./100 g weight) or potassium iodide (3 mg per rat) were injected every 12 h for 3 days. Thereafter the thyroglobulin content in thyroid gland homogenates was measured. PTU pre-treatment lowered the thyroglobulin content from 4.21 to 0.22 mg/100 mg gland. Lithium caused a marked re-accumulation of thyroglobulin to 0.60 mg/100 mg within 3 days. While iodide alone had only a borderline effect, it markedly potentiated the action of lithium and a combination of the two drugs increased the thyroglobulin content to 1.04 mg/100 mg. Thyroxine was injected into similarly pre-treated animals to suppress secretion of thyrotrophic hormone. This markedly inhibited the proteolysis of thyroglobulin and 1.3 mg/100 mg gland accumulated after 3 days. Excess iodide, given in addition to thyroxine, decreased the amount of thyroglobulin accumulated to 0.75 mg/100 mg gland. To study whether this could be explained by an inhibitory action of iodide on thyroglobulin biosynthesis, thyroid glands from animals treated with excess iodide were incubated in vitro in the presence of 0.2 mm iodide for 3 h. Iodide decreased the incorporation of radioactive leucine into total thyroidal protein and into thyroglobulin by 25 and 35 % respectively. Iodide did not inhibit protein synthesis in the kidney, liver or muscle tissue. Thus, large doses of iodide selectively inhibit thyroglobulin biosynthesis.

THE EFFECT OF THYROTROPHIC HORMONE ON THE PLASMA THYROID HORMONES IN MAN

1963 ◽  
Vol 12 (1) ◽  
pp. 30-36 ◽  
Author(s):  
MAURICE L. WELLBY ◽  
BASIL S. HETZEL ◽  
MARGARET L. ISAACHSEN
Keyword(s):  
Thyroid Hormones ◽  
Thyrotrophic Hormone

scholarly journals Changes in hormonal and metabolic status in men of an ethnic group Komi with overweight and obesity

2013 ◽  
Vol 10 (2) ◽  
pp. 28-32
Author(s):  
L V Osadchuk ◽  
N V Gutorova ◽  
A Yu Ludinina ◽  
N N Potolitsyna ◽  
E R Bojko
Keyword(s):  
Ethnic Group ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Komi Republic ◽  
Overweight And Obesity ◽  
Control Group ◽  
Reproductive Hormone ◽  
Serum Concentrations ◽  
Low Density Lipoprotein Cholesterol ◽  
Thyrotrophic Hormone

The aim of this study was to compare hormonal, anthropometric and metabolic parameters in men of the komi ethnic group with (n=23, BMI ≥25 kg/м2) or without (n=39, 18.4≤BMI 25 kg/м2) obesity. Totally 62 males living in Komi Republic were included in the study. It has been established that obesity was accompanied by an increase in serum concentrations of cholesterol and low density lipoprotein cholesterol in comparison with control group indicating metabolic disturbance. The data shows the significant effect of BMI on testosterone and FSH serum concentration, but not on LH, estradiol, thyrotrophic hormone, thyroxin and triiodthyronin levels. Overweight and obese men had lower circulating testosterone and higher FSH level in comparison with the controls. The reproductive hormone changes in overweight and obese men can result in deleterious effects on sexual functions including erectile dysfunction, reduced libido and alteration in spermatogenesis

THE DISAPPEARANCE RATE OF THYROTROPHIC HORMONE FROM THE BLOODSTREAM OF NORMAL AND THYROIDECTOMIZED RABBITS

1955 ◽  
Vol 19 (2) ◽  
pp. 152-156 ◽  
Author(s):  
A. Querido ◽  
A. A. H. Kassenaar ◽  
L. D. F. Lameyer
Keyword(s):  
Disappearance Rate ◽  
Thyrotrophic Hormone

THE SEPARATION AND PURIFICATION OF HUMAN LUTEINIZING AND THYROTROPHIC HORMONES

1964 ◽  
Vol 29 (1) ◽  
pp. 61-69 ◽  
Author(s):  
ANNE STOCKELL HARTREE ◽  
W. R. BUTT ◽  
K. E. KIRKHAM
Keyword(s):  
Luteinizing Hormone ◽  
Ion Exchange ◽  
Deae Cellulose ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Separation And Purification ◽  
Hormone Activity ◽  
Human Pituitary ◽  
Thyrotrophic Hormone

SUMMARY Ion-exchange chromatography was used to further purify a human pituitary fraction rich in thyrotrophic and luteinizing hormone activities. Approximately twofold concentration of both activities was obtained by chromatography on IRC-50 at pH 7·5, but the hormones were not separated. Subsequent chromatography on DEAE-cellulose at pH 9·5 led to a tenfold concentration of the luteinizing hormone in a fraction practically free of thyrotrophic activity and to a fourfold concentration of the thyrotrophic hormone in a fraction still exhibiting substantial luteinizing hormone activity.

scholarly journals Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome

1977 ◽  
Vol 35 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Benjamin J. Schmidt ◽  
Nelson Carvalho ◽  
Stanislau Krynski ◽  
Cláudio C. Ortega ◽  
José Liberman ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Thyroid Dysfunction ◽  
Clearance Rates ◽  
Radioiodine Uptake ◽  
Children With Down Syndrome ◽  
Normal Limits ◽  
Thyrotrophic Hormone ◽  
Thyroid Uptake ◽  
Before And After ◽  
Serum Tsh

Serum TSH was studied in 22 patients with Down syndrome, from 4 to 15 years old. In 6 of these patients radioiodine uptake by thyroid gland after 2 and 24 hours of administration and clearance rates before and after TSH stimulus (10 µl-IM) were measured. Results show that serum TSH was normal in 17 patients and above normal limits in 5 patients. Thyroid uptake after 2 hours as well clearance rates, both below normal, had a response to TSH stimulus with normal or below values. These data along with previous reports, suggest, that in children with Down syndrome, there is a thyroid dysfunction in which a slow response no TSH stimulus seems to be the basic defect.

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