scholarly journals Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome

1977 ◽  
Vol 35 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Benjamin J. Schmidt ◽  
Nelson Carvalho ◽  
Stanislau Krynski ◽  
Cláudio C. Ortega ◽  
José Liberman ◽  
...  

Serum TSH was studied in 22 patients with Down syndrome, from 4 to 15 years old. In 6 of these patients radioiodine uptake by thyroid gland after 2 and 24 hours of administration and clearance rates before and after TSH stimulus (10 µl-IM) were measured. Results show that serum TSH was normal in 17 patients and above normal limits in 5 patients. Thyroid uptake after 2 hours as well clearance rates, both below normal, had a response to TSH stimulus with normal or below values. These data along with previous reports, suggest, that in children with Down syndrome, there is a thyroid dysfunction in which a slow response no TSH stimulus seems to be the basic defect.

Author(s):  
Gražina Krutulytė ◽  
Birutė Vilimienė ◽  
Inga Juškaitė

Movement is an inexhaustible means of self realization, self expression and the way of learning about the surrounding world for children with physical and mental disabilities. Due to the lack of general and fine movements child’s coordination might be impaired. Different methods of motor learning increase child’s ability to perform correct movements and enable them in taking care of themselves, in communicating and gaining knowledge. The objective of the research was to determine the influence of physiotherapy on hand movements of the children suffering from cerebral paralysis, Down syndrome and autism. The tasks of the research: 1. To determine the indicators of hand movement functions of children suffering from cerebral paralysis, Down syndrome and autism before and after physiotherapy. 2. To compare the research indicators of hand movement functions of the children suffering from cerebral paralysis, Down syndrome and autism. Twenty seven children diagnosed with cerebral paralysis, Down syndrome and autism participated in the research. Their age was from 10 to 17 years. Mental disability of most of the children was moderate. The children were divided into three groups: the first group consisted of 13 children with cerebral paralysis, the second group – 8 children with Down syndrome, the third group – 6 children with the diagnosis of autism. Before the first physiotherapy activity the children of all three groups had their hand movements, the frequency of hand movements and their speed researched. The second study was performed after the first physiotherapy activity which lasted for two months, three times a week, thirty minutes a day. The third study was performed after the second physiotherapy activity which followed the first one and lasted for two months, three times a week, thirty minutes twice a day. Physiotherapy program consisted of stretching and exercises exercises for strength, movements for fine and gross motorics and a game. The exercises were done individually, making them more intensive step by step. The tepping test was used to measure the speed and the frequency of hand movements. The strength of muscles was measured with the help of a mechanic dynamometer. The results demonstrate that physiotherapy is effective. The functions of hand movements of children suffering from cerebral paralysis, Down syndrome and autism have improved. The frequency and the speed of hand movements, as well as muscular strength have increased (p < 0.05). Having compared the data of all three research groups we can make a conclusion that the kind of physiotherapy employed was more effective for the children with Down syndrome and autism than for those who had cerebral paralysis.Keywords: kinesitherapy, cerebral palsy, Down syndrome, autism.


2020 ◽  
Vol 23 (6) ◽  
pp. 386-390
Author(s):  
Beata Zelazowska-Rutkowska ◽  
Anna Jakubiuk-Tomaszuk ◽  
Bogdan Cylwik

Background: Patients with subclinical thyroid disease have few or no clinical symptoms of thyroid dysfunction and thus, laboratory diagnosis is needed. In this context, the objective of the current study was to analyze the prevalence rate and pattern of thyroid function in children with Down syndrome in the Polish population. Methods: A total of 30 children, aged 6–12 years, with cytogenetically confirmed Down syndrome were studied. The control group included 27 children. Results: Of the 30 patients with Down syndrome, 14 (46.7%) had abnormal thyroid profiles. Mean thyroid-stimulating hormone (TSH) and fT4 concentrations in children with Down syndrome were found to be significantly increased compared with the controls (4.30 ± 1.9 µIU/mL, 95% CI: 3.55–5.04 µIU/mL vs. 3.10 ± 1.47 µIU/mL, 95% CI: 2.52–3.68 µIU/mL, P = 0.013, 95% CI: 0.26–2.14, and 1.33 ± 0.23 ng/dL, 95% CI: 1.25–1.42 vs. 1.19 ± 0.14 ng/dL, 95% CI: 1.13–1.25, P = 0.008, 95% CI: 0.04–0.24, respectively). In Down syndrome, subclinical hypothyroidism was recognized in 10 children (33.3%) (high TSH and normal fT4 and fT3 levels). Two children (6.67%) had evident hypothyroidism (high TSH and low fT4). In the control group, subclinical hypothyroidism was diagnosed in four (14.8%) children. Conclusion: Children with Down syndrome may have increased secretion of TSH, even when thyroid hormone and autoantibodies are normal, suggesting that an isolated increase in TSH does not predispose the patient to the development of thyroid disease. We also recommend that all patients with Down syndrome should be screened for thyroid dysgenesis, since they have thyroid dysfunction more frequently as compared to the general healthy population.


2018 ◽  
Vol 22 (1) ◽  
pp. 6-9
Author(s):  
Vidhya Vishwanathan ◽  
Subramanian Sethuraman ◽  
Shanthi Balaji ◽  
VS Kalai Selvi ◽  
AJ Manjula Devi

1994 ◽  
Vol 14 (4) ◽  
pp. 283-285 ◽  
Author(s):  
Mohamed Ahmed Abdullah ◽  
Hussain Salman ◽  
Sulaiman Al-Habib ◽  
Abdulrahman Ghareeb ◽  
Ahmed Abanamy

2006 ◽  
Vol 30 (4) ◽  
pp. 325-328 ◽  
Author(s):  
H Korbmacher ◽  
J Limbrock ◽  
B Kahl-Nieke

The aim of this investigation was to evaluate the long-term orofacial development of Down children who received plate therapy according to Castillo Morales in their early childhood. The orofacial development of 27 Down children was documented before and after plate therapy and at a follow-up examination 13 years ± 6 months after initiation of therapy. The orofacial appearance significantly improved during therapy (p=0.00). During the follow-up, mouth posture remained stable (p=0.259), whereas tongue position further improved (p=0.034). A better long-term development was documented in children with initial severe orofacial dysfunctions.


2021 ◽  
Vol 11 (3) ◽  
pp. 191-196
Author(s):  
Fahmida Zabeen ◽  
Fauzia Mohsin ◽  
Eva Jesmin ◽  
Sharmin Mahbuba ◽  
M Quamrul Hassan

Background: Down syndrome or trisomy 21 is one of the most common chromosomal disorders with moderate intellectual disability. In addition to mental retardation, this syndrome is associated with different congenital anomalies and characteristic dysmorphic features. Affected individuals are more susceptible to congenital heart disease and digestive anomalies, pulmonary complications, immune and endocrine system disorders. While several international studies have shown association of co-morbidities with trisomy 21, there is insufficient data available in Bangladesh.The present study aimed to evaluate the associated co-morbidities in children with Down syndrome. Methods: A cross-sectional study was conducted among pediatric cases with Down syndrome who attended the endocrine outpatient department (OPD) of BIRDEM General Hospital from June 2006 to December 2016. The cases were diagnosed either by Karyotyping or by characteristic phenotypes.The clinical and laboratory data of the patients were collected from outpatient history records for analysis. Results: There were total 42 children with Down syndrome, with mean age 4.2 years at assessment and female predominance (1.47:1). Thyroid dysfunction was the most common (69%) followed by congenital heart disease (57%). Among the thyroid disorders, acquired hypothyroidism was found in 55% cases, congenital hypothyroidism in 41% cases and only one had hyperthyroidism. Isolated patent ductus arteriosus (PDA) and atrial septal defect (ASD) comprised the commonest single congenital heart disease found in 53% and combined atrioventricular septal defect was the commonest among complex congenital cardiac defect observed in our study. Both thyroid dysfunction and congenital heart disease were found more in female children with Down syndrome than their male counterpart and it was found statistically significant. Fifty percent of our Down syndrome cases were referred from other healthcare centers to address developmental delay. Conclusion: Hypothyroidism and congenital heart disease are frequently associated in Down syndrome children in Bangladesh. This calls for developing awareness among health professionals to diagnose comorbidities at an early stage and to form recommendations for long term follow up. BIRDEM Med J 2021; 11(3): 191-196


2015 ◽  
Vol 6 (03) ◽  
pp. 339-343 ◽  
Author(s):  
Pratiksha Tilak Rao ◽  
John M. Solomon

ABSTRACT Aims: Response time (RT), that is, the time taken to respond is known to be delayed in children with Down syndrome (DS). We performed a pilot study to evaluate whether bilateral limb training can be used to train RT, in children with DS. Settings and Design: 10 children with DS (5 males) were recruited from a special school in a suburban region using convenience sampling. Subjects and Methods: Response time was measured using an indigenously developed RT Analyzer, before and after intervention, from right and left hand. Structured bilateral limb training was given for a period of 4 weeks, using low-cost, locally available materials, in community settings. Statistical Analysis Used: The Wilcoxon signed ranks test was used for statistical analysis. Results: Significant improvements in RT following 4 weeks of intervention were seen in the left hand (P = 0.006) but not in the right hand (P = 0.104). Conclusions: Response time can be trained in children with DS using 4 weeks of bilateral limb training activities using low-cost, locally available materials.


2015 ◽  
Vol 20 (5) ◽  
pp. 1363-1369 ◽  
Author(s):  
Vivian Renne Gerber Lederman ◽  
Bianca dos Santos Alves ◽  
Juliana Negrão ◽  
José Salomão Schwartzman ◽  
Maria Eloisa Famá D'Antino ◽  
...  

This study evaluates the impact in the stability and management of the marriage of parents of a child with Down or Rett Syndrome. Morbidity of the syndromes and the marital status of the couples before and after the birth of the affected children were considered variables. The divorce rate in families with Down syndrome was 10%, similar to the Brazilian rate population. In Rett Syndrome, the divorce rate was significantly higher, 23.5%. The higher morbidity of Rett Syndrome, and the moment of diagnosis could be relevant factors for the increased divorce rate related to this syndrome.


2013 ◽  
Vol 103 (12) ◽  
pp. 966 ◽  
Author(s):  
Shahida Moosa ◽  
David G Segal ◽  
Arnold L Christianson ◽  
Nerine E Gregersen

Sign in / Sign up

Export Citation Format

Share Document