This chapter discusses whether and how complex systems science (CSS) can revolutionize population health theory. First, the chapter defines theory and the practice of theory-building (or theorizing); second, it outlines some of the difficulties found in current population health theorizing; lastly, it characterizes the mechanisms through which CSS can influence, change, and revolutionize current theorizing efforts. The chapter also describes two examples of scholars who used CSS to challenge currently held assumptions and reframe complex health problems. Lastly, the author addresses the implications—of adopting a CSS approach to theorizing—for practice, policy development, and training of the future public health workforce.