Direct 3D Printing of High Strength Biohybrid Gradient Hydrogel Scaffolds for Efficient Repair of Osteochondral Defect

2018 ◽  
Vol 28 (13) ◽  
pp. 1706644 ◽  
Author(s):  
Fei Gao ◽  
Ziyang Xu ◽  
Qingfei Liang ◽  
Bo Liu ◽  
Haofei Li ◽  
...  
2020 ◽  
Vol 8 (18) ◽  
pp. 5020-5028 ◽  
Author(s):  
Luyu Zhou ◽  
Hamed Ramezani ◽  
Miao Sun ◽  
Mingjun Xie ◽  
Jing Nie ◽  
...  

Here, a novel direct ink printing method was developed to print high-strength chitosan hydrogel scaffolds without any organic solvents.


Author(s):  
Ana A. Aldana ◽  
Marina Uhart ◽  
Gustavo A. Abraham ◽  
Diego M. Bustos ◽  
Aldo R. Boccaccini

Abstract3D printing has emerged as vanguard technique of biofabrication to assemble cells, biomaterials and biomolecules in a spatially controlled manner to reproduce native tissues. In this work, gelatin methacrylate (GelMA)/alginate hydrogel scaffolds were obtained by 3D printing and 14-3-3ε protein was encapsulated in the hydrogel to induce osteogenic differentiation of human adipose-derived mesenchymal stem cells (hASC). GelMA/alginate-based grid-like structures were printed and remained stable upon photo-crosslinking. The viscosity of alginate allowed to control the pore size and strand width. A higher viscosity of hydrogel ink enhanced the printing accuracy. Protein-loaded GelMA/alginate-based hydrogel showed a clear induction of the osteogenic differentiation of hASC cells. The results are relevant for future developments of GelMA/alginate for bone tissue engineering given the positive effect of 14-3-3ε protein on both cell adhesion and proliferation.


2020 ◽  
Vol 109 (1) ◽  
pp. 54-63
Author(s):  
Bijan Abar ◽  
Alejandro Alonso‐Calleja ◽  
Alexander Kelly ◽  
Cambre Kelly ◽  
Ken Gall ◽  
...  

2018 ◽  
Vol 160 ◽  
pp. 9-20 ◽  
Author(s):  
Nadim S. Hmeidat ◽  
James W. Kemp ◽  
Brett G. Compton

2019 ◽  
Vol 52 (6) ◽  
pp. 2456-2463 ◽  
Author(s):  
Jianfei Liu ◽  
Pei Wang ◽  
Yinan He ◽  
Kaiqiang Liu ◽  
Rong Miao ◽  
...  

2019 ◽  
Vol 171 ◽  
pp. 107708 ◽  
Author(s):  
Jingyi Liu ◽  
Liang Li ◽  
Hairui Suo ◽  
Mengling Yan ◽  
Jun Yin ◽  
...  

2020 ◽  
Vol 46 (5) ◽  
pp. 6978-6983 ◽  
Author(s):  
Quan Zhu ◽  
Xiang Dong ◽  
Jianbao Hu ◽  
Jinshan Yang ◽  
Xiangyu Zhang ◽  
...  

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