An Oxygen Self‐Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment

2019 ◽  
Vol 9 (2) ◽  
pp. 1901303 ◽  
Author(s):  
Wei Jiang ◽  
Xiaoxue Han ◽  
Taixing Zhang ◽  
Diya Xie ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Delivery System ◽  
Tumor Treatment ◽  
Hypoxic Tumor

A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

2021 ◽  
Vol 57 (34) ◽  
pp. 4134-4137
Author(s):  
Rongrong Zheng‡ ◽  
Xiayun Chen‡ ◽  
Linping Zhao ◽  
Ni Yang ◽  
Runtian Guan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondrial Respiration ◽  
Tumor Treatment ◽  
Hypoxic Tumor

A porphysome-based photodynamic O2 economizer is developed to inhibit mitochondrial respiration for enhanced photodynamic therapy against hypoxic tumors.

Nanozyme with Robust Catalase Activity by Multiple Mechanisms and Its Application for Hypoxic Tumor Treatment

2021 ◽  
pp. 2100601
Author(s):  
Chongchong Wang ◽  
Yanqing Li ◽  
Weijie Yang ◽  
Lin Zhou ◽  
Shaohua Wei
Keyword(s):  
Catalase Activity ◽  
Tumor Treatment ◽  
Hypoxic Tumor

scholarly journals Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2058
Author(s):  
Liang Hong ◽  
Artem M. Pliss ◽  
Ye Zhan ◽  
Wenhan Zheng ◽  
Jun Xia ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Single Cells ◽  
Oxygen Carrier ◽  
Chlorin E6 ◽  
Tumor Treatment ◽  
Selective Treatment ◽  
Deep Tissue ◽  
Sonodynamic Therapy ◽  
Tumor Environment ◽  
Hypoxic Tumor

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment

2020 ◽  
Author(s):  
Xiao Fang ◽  
Shuxian Cai ◽  
Min Wang ◽  
Zhaowei Chen ◽  
Chunhua Lu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Tumor Treatment ◽  
Oxide Production ◽  
Hypoxic Tumor

Efficient Self-Assembled MicroRNA Delivery System Consisting of Cholesterol-Conjugated MicroRNA and PEGylated Polycationic Polymer for Tumor Treatment

2019 ◽  
Vol 2 (5) ◽  
pp. 2219-2228 ◽  
Author(s):  
Byeonggeol Mun ◽  
Eunji Jang ◽  
Seungmin Han ◽  
Hye Young Son ◽  
Yuna Choi ◽  
...  
Keyword(s):  
Delivery System ◽  
Tumor Treatment ◽  
Self Assembled ◽  
Microrna Delivery

A multi-functional drug delivery system based on polyphenols for efficient tumor inhibition and metastasis prevention

2020 ◽  
Vol 8 (2) ◽  
pp. 702-711 ◽  
Author(s):  
Si Chen ◽  
Jin-Xuan Fan ◽  
Di-Wei Zheng ◽  
Fan Liu ◽  
Xuan Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Treatment ◽  
Tumor Inhibition ◽  
Integrated Therapy

A multi-functional drug delivery system EINP@DOX, which integrated therapy, imaging and anti-metastatic functions, was constructed to realize a systematic tumor treatment.

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