A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

2021 ◽  
Vol 57 (34) ◽  
pp. 4134-4137
Author(s):  
Rongrong Zheng‡ ◽  
Xiayun Chen‡ ◽  
Linping Zhao ◽  
Ni Yang ◽  
Runtian Guan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondrial Respiration ◽  
Tumor Treatment ◽  
Hypoxic Tumor

A porphysome-based photodynamic O2 economizer is developed to inhibit mitochondrial respiration for enhanced photodynamic therapy against hypoxic tumors.

scholarly journals Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2058
Author(s):  
Liang Hong ◽  
Artem M. Pliss ◽  
Ye Zhan ◽  
Wenhan Zheng ◽  
Jun Xia ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Single Cells ◽  
Oxygen Carrier ◽  
Chlorin E6 ◽  
Tumor Treatment ◽  
Selective Treatment ◽  
Deep Tissue ◽  
Sonodynamic Therapy ◽  
Tumor Environment ◽  
Hypoxic Tumor

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

scholarly journals Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Zijun Shen ◽  
Qingming Ma ◽  
Xinyu Zhou ◽  
Guimin Zhang ◽  
Guizhou Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia ◽  
Reactive Oxygen ◽  
Therapeutic Effects ◽  
Oxygen Carriers ◽  
Tumor Treatment ◽  
Tumor Microenvironments ◽  
Multiple Strategies ◽  
Hypoxic Tumor

AbstractPhotodynamic therapy (PDT) is an emerging technology for tumor treatment in which photosensitizer (PS)-mediated light irradiation reduces oxygen, producing high levels of reactive oxygen species (ROS) that can cause vascular injury and effectively kill tumor cells. However, the naturally hypoxic tumor microenvironment is the main obstacle that hinders the photodynamic response in vivo and prevents its extensive application to tumor treatment. Moreover, PDT-mediated oxygen consumption further increases tumor hypoxia, potentially causing a variety of adverse consequences, such as angiogenesis, tumor invasion, and metastasis. To overcome these limitations caused by hypoxia, multiple strategies have been investigated, including the use of oxygen carriers and reactive oxygen supply materials, the regulation of tumor microenvironments, and multimodal therapy including PDT. In this review, we summarize the latest progress in the development of strategies to relieve tumor hypoxia for improved PDT efficacy and better therapeutic effects.

A smart copper-phthalocyanine framework nanoparticle for enhancing photodynamic therapy in hypoxic conditions by weakening cells through ATP depletion

2018 ◽  
Vol 6 (14) ◽  
pp. 2078-2088 ◽  
Author(s):  
Li Gui ◽  
Jiahong Zhou ◽  
Lin Zhou ◽  
Shaohua Wei
Keyword(s):  
Photodynamic Therapy ◽  
Copper Phthalocyanine ◽  
Atp Depletion ◽  
Tumor Treatment ◽  
Hypoxic Conditions ◽  
Hypoxic Tumor

Hypoxic tumor treatment by synergistic of photodynamic therapy and ATP deprivation.

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

2021 ◽  
Author(s):  
Endong Zhang ◽  
Zicheng Zuo ◽  
Wen Yu ◽  
Hao Zhao ◽  
Shengpeng Xia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Conjugated Polymer ◽  
Tumor Therapy ◽  
Living Cells ◽  
Tumor Treatment ◽  
Treatment Efficiency ◽  
Therapy Strategy ◽  
Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

Nanozyme with Robust Catalase Activity by Multiple Mechanisms and Its Application for Hypoxic Tumor Treatment

2021 ◽  
pp. 2100601
Author(s):  
Chongchong Wang ◽  
Yanqing Li ◽  
Weijie Yang ◽  
Lin Zhou ◽  
Shaohua Wei
Keyword(s):  
Catalase Activity ◽  
Tumor Treatment ◽  
Hypoxic Tumor

Oxygen-producing proenzyme hydrogels for photodynamic mediated metastasis-inhibited combinational therapy

2021 ◽  
Author(s):  
Jiansheng Liu ◽  
Xueqin Qing ◽  
Qin Zhang ◽  
Ningyue Yu ◽  
Mengbin Ding ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Therapeutic Efficacy ◽  
Tumor Metastasis ◽  
Combinational Therapy ◽  
Hypoxic Tumor

Photodynamic therapy (PDT) has provided a promising approach for treatment of solid tumors, while the therapeutic efficacy is often limited due to hypoxic tumor microenvironment, resulting in tumor metastasis. We...

scholarly journals Tailoring photosensitive ROS for advanced photodynamic therapy

2021 ◽  
Author(s):  
Duc Loc Sai ◽  
Jieun Lee ◽  
Duc Long Nguyen ◽  
Young-Pil Kim
Keyword(s):  
Photodynamic Therapy ◽  
Reactive Oxygen Species Generation ◽  
Cost Effective ◽  
Molecular Medicine ◽  
Oxygen Species ◽  
Significant Progress ◽  
Tumor Treatment ◽  
Innovative Strategies ◽  
Tumor Microenvironments ◽  
Future Challenges

AbstractPhotodynamic therapy (PDT) has been considered a noninvasive and cost-effective modality for tumor treatment. However, the complexity of tumor microenvironments poses challenges to the implementation of traditional PDT. Here, we review recent advances in PDT to resolve the current problems. Major breakthroughs in PDTs are enabling significant progress in molecular medicine and are interconnected with innovative strategies based on smart bio/nanomaterials or therapeutic insights. We focus on newly developed PDT strategies designed by tailoring photosensitive reactive oxygen species generation, which include the use of proteinaceous photosensitizers, self-illumination, or oxygen-independent approaches. While these updated PDT platforms are expected to enable major advances in cancer treatment, addressing future challenges related to biosafety and target specificity is discussed throughout as a necessary goal to expand the usefulness of PDT.

scholarly journals Photodynamic Therapy for Advanced Rectal Cancer: A Case Report

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Lemei Chen ◽  
Yanping Liu ◽  
Ping Xie ◽  
Huizhen Fan
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Photodynamic Therapy ◽  
Palliative Treatment ◽  
Treatment Process ◽  
Advanced Colorectal Cancer ◽  
Advanced Rectal Cancer ◽  
Tumor Treatment ◽  
Potential Value ◽  
Case Data

Objective: To investigate the potential value of PDT(photodynamic therapy) in the treatment of rectal cancer by reviewing the diagnosis and treatment process of a patient with advanced rectal cancer who lost the opportunity of surgery. Methods: Select the case data of a patient receiving photodynamic therapy in our hospital, and analyze the photodynamic mechanism, safety and efficiency, and discuss the efficacy of photodynamic therapy. Results: After the patient received photodynamic therapy, re-examination of the endoscopy showed that the intestinal cavity was smoother than before, the bowel was difficult, and the symptoms of blood in the stool improved. Conclusion: Photodynamic therapy can be used as a radical or palliative treatment for clinical tumor treatment. Because of its advantages of minimally invasive, tissue-specific, repetitive and synergistic radiotherapy and chemotherapy, it plays an important role in early or middle-advanced colorectal cancer and is worthy of clinical promotion.

Acute phase response induced following tumor treatment by photodynamic therapy: relevance for the therapy outcome

2006 ◽  
Author(s):  
Mladen Korbelik ◽  
Soroush Merchant ◽  
Brandon Stott ◽  
Ivana Cecic ◽  
Peter Payne ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Therapy Outcome ◽  
Tumor Treatment
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