Nanozyme with Robust Catalase Activity by Multiple Mechanisms and Its Application for Hypoxic Tumor Treatment

2021 ◽  
pp. 2100601
Author(s):  
Chongchong Wang ◽  
Yanqing Li ◽  
Weijie Yang ◽  
Lin Zhou ◽  
Shaohua Wei
Keyword(s):  
Catalase Activity ◽  
Tumor Treatment ◽  
Hypoxic Tumor

A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

2021 ◽  
Vol 57 (34) ◽  
pp. 4134-4137
Author(s):  
Rongrong Zheng‡ ◽  
Xiayun Chen‡ ◽  
Linping Zhao ◽  
Ni Yang ◽  
Runtian Guan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondrial Respiration ◽  
Tumor Treatment ◽  
Hypoxic Tumor

A porphysome-based photodynamic O2 economizer is developed to inhibit mitochondrial respiration for enhanced photodynamic therapy against hypoxic tumors.

scholarly journals Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2058
Author(s):  
Liang Hong ◽  
Artem M. Pliss ◽  
Ye Zhan ◽  
Wenhan Zheng ◽  
Jun Xia ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Single Cells ◽  
Oxygen Carrier ◽  
Chlorin E6 ◽  
Tumor Treatment ◽  
Selective Treatment ◽  
Deep Tissue ◽  
Sonodynamic Therapy ◽  
Tumor Environment ◽  
Hypoxic Tumor

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

Photogenerated Holes Mediated Nitric Oxide Production for Hypoxic Tumor Treatment

2020 ◽  
Author(s):  
Xiao Fang ◽  
Shuxian Cai ◽  
Min Wang ◽  
Zhaowei Chen ◽  
Chunhua Lu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Tumor Treatment ◽  
Oxide Production ◽  
Hypoxic Tumor

Mitochondria-targeted nanotheranostic: Harnessing single-laser-activated dual phototherapeutic processing for hypoxic tumor treatment

Matter ◽  
2021 ◽  
Author(s):  
Jinwoo Shin ◽  
Yuling Xu ◽  
Seyoung Koo ◽  
Jong Hyeon Lim ◽  
Jin Yong Lee ◽  
...  
Keyword(s):  
Tumor Treatment ◽  
Single Laser ◽  
Hypoxic Tumor

scholarly journals Mitochondria-targeted nanotheranostic: Harnessing single-laser-activated dual phototherapeutic processing for hypoxic tumor treatment

Matter ◽  
2021 ◽  
Vol 4 (9) ◽  
pp. 3068-3069
Author(s):  
Jinwoo Shin ◽  
Yuling Xu ◽  
Seyoung Koo ◽  
Jong Hyeon Lim ◽  
Jin Yong Lee ◽  
...  
Keyword(s):  
Tumor Treatment ◽  
Single Laser ◽  
Hypoxic Tumor

scholarly journals Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Qian Cheng ◽  
Zi-Hao Li ◽  
Yun-Xia Sun ◽  
Xian-Zheng Zhang
Keyword(s):  
Tumor Cells ◽  
Core Shell ◽  
Tumor Treatment ◽  
Tumor Cell Membrane ◽  
Image Guided ◽  
Simple Strategy ◽  
Hypoxic Tumor ◽  
Targeting Ability ◽  
Shock Proteins ◽  
Imaging Performance

Abstract In this paper, a simple strategy is proposed to prepare a core-shell nanohybrid (PB@PCN) by the controllable coating of zirconium-porphyrin (PCN) shells on Prussian blue (PB) nanoparticles. By adjusting the thickness of the PCN shell, the PB@PCN nanohybrid with the best comprehensive performance was obtained for tumor treatment and imaging. The integrated nanosystem as a tandem catalyst is able to convert H2O2 to O2 through the PB core, and then the O2 is directly injected into the PCN framework, leading to a high quantum yield of singlet oxygen to kill tumor cells and attack heat shock proteins (HSPs). The nanohybrid was further camouflaged by a tumor cell membrane (PB@PCN@MEM) with good immune evasion and active targeting ability. Upon accumulation at the tumor site, PN@PCN@MEM showed an enhanced photodynamic therapeutic effect against hypoxic tumor cells. Furthermore, coupled with the photothermal therapy of PB, photothermal/photodynamic synergistic therapy of tumors can be realized. In addition, due to its excellent imaging performance, this core-shell nanohybrid can be employed for the multimodal image-guided therapy of tumors.

scholarly journals Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Zijun Shen ◽  
Qingming Ma ◽  
Xinyu Zhou ◽  
Guimin Zhang ◽  
Guizhou Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia ◽  
Reactive Oxygen ◽  
Therapeutic Effects ◽  
Oxygen Carriers ◽  
Tumor Treatment ◽  
Tumor Microenvironments ◽  
Multiple Strategies ◽  
Hypoxic Tumor

AbstractPhotodynamic therapy (PDT) is an emerging technology for tumor treatment in which photosensitizer (PS)-mediated light irradiation reduces oxygen, producing high levels of reactive oxygen species (ROS) that can cause vascular injury and effectively kill tumor cells. However, the naturally hypoxic tumor microenvironment is the main obstacle that hinders the photodynamic response in vivo and prevents its extensive application to tumor treatment. Moreover, PDT-mediated oxygen consumption further increases tumor hypoxia, potentially causing a variety of adverse consequences, such as angiogenesis, tumor invasion, and metastasis. To overcome these limitations caused by hypoxia, multiple strategies have been investigated, including the use of oxygen carriers and reactive oxygen supply materials, the regulation of tumor microenvironments, and multimodal therapy including PDT. In this review, we summarize the latest progress in the development of strategies to relieve tumor hypoxia for improved PDT efficacy and better therapeutic effects.

scholarly journals The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Asieh Emami Nejad ◽  
Simin Najafgholian ◽  
Alireza Rostami ◽  
Alireza Sistani ◽  
Samaneh Shojaeifar ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Therapeutic Response ◽  
Clonal Selection ◽  
Tumor Biology ◽  
Tumor Hypoxia ◽  
Tumor Treatment ◽  
Novel Approach ◽  
Hypoxic Tumor ◽  
Potential Use

AbstractHypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, thereby enhancing invasiveness and risk of metastasis; increase survival of tumor, as well as suppress anti-tumor immunity and hamper the therapeutic response. Hypoxia mediates these effects by several potential mechanisms: altering gene expression, the activation of oncogenes, inactivation of suppressor genes, reducing genomic stability and clonal selection. We have reviewed the effects of hypoxia on tumor biology and the possible strategiesto manage the hypoxic tumor microenvironment (TME), highlighting the potential use of cancer stem cells in tumor treatment.

An Oxygen Self‐Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment

2019 ◽  
Vol 9 (2) ◽  
pp. 1901303 ◽  
Author(s):  
Wei Jiang ◽  
Xiaoxue Han ◽  
Taixing Zhang ◽  
Diya Xie ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Delivery System ◽  
Tumor Treatment ◽  
Hypoxic Tumor
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